Arterial spin labeling using spatio‐temporal encoding readout for robust perfusion imaging in inhomogenous magnetic fields
Magnetic Resonance in Medicine, vol. 89, pp. 1092–1101
Abstract
PURPOSE: To evaluate the feasibility of spatio-temporal encoding (SPEN) readout for pseudo-continuous ASL (pCASL) in brain, and its robustness to susceptibility artifacts as introduced by aneurysm clips. METHODS: ) was varied and, the aneurysm clip-induced artifact was evaluated in phantom (label-images) as well as in vivo (perfusion-weighted signal (PWS)-maps and temporal SNR (tSNR)). In vivo results were compared to gradient-echo EPI (GE-EPI) and spin-echo EPI (SE-EPI). The dependence of tSNR on TR was evaluated separately for SPEN and SE-EPI. SPEN with Q ˜ 75 encodes with the same off-resonance robustness as EPI. RESULTS: The clip-induced artifact with SPEN decreased with increase in Q, and was smaller compared to SE-EPI and GE-EPI in vivo. tSNR decreased with Q and the tSNR of GE-EPI and SE-EPI corresponded to SPEN with a Q-value of approximately ˜85 and ˜108, respectively. In addition, SPEN perfusion images showed a higher tSNR (p < 0.05) for TR = 4000 ms compared to TR = 2100 ms, while SE-EPI did not. tSNR remained relatively stable when the time between SPEN-excitation and start of the next labeling-module was more than ˜1000 ms. CONCLUSION: Feasibility of combining SPEN with pCASL imaging was demonstrated, enabling cerebral perfusion measurements with a higher robustness to field inhomogeneity (Q > 75) compared to SE-EPI and GE-EPI. However, the SPEN chirp-pulse saturates incoming blood, thereby reducing pCASL labeling efficiency of the next acquisition for short TRs. Future developments are needed to enable 3D scanning.
Authors 6
-
Suzanne L. Franklin Aachen C.J. Gorter Center for High Field MRI Department of Radiology Leiden University Medical Center Leiden The Netherlands Department of Radiology, Leiden University Medical Center
Leiden University Medical Center · University Medical Center Utrecht
Affiliation as printed
C.J. Gorter Center for High Field MRI, Department of Radiology Leiden University Medical Center Leiden The Netherlands
Center for Image Sciences University Medical Center Utrecht Utrecht The Netherlands
C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands
-
University Medical Center Utrecht
Affiliation as printed
Center for Image Sciences University Medical Center Utrecht Utrecht The Netherlands
Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands
-
Affiliation as printed
Department of Chemical and Biological Physics Weizmann Institute of Science Rehovot Israel
Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel
-
University Medical Center Utrecht
Affiliation as printed
Department of Radiotherapy University Medical Center Utrecht Utrecht The Netherlands
Department of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands
-
Matthias J.P. van Osch Aachen C.J. Gorter Center for High Field MRI Department of Radiology Leiden University Medical Center Leiden The Netherlands Department of Radiology, Leiden University Medical Center Leiden Institute for Brain and Cognition
Leiden University · Leiden University Medical Center
Affiliation as printed
C.J. Gorter Center for High Field MRI, Department of Radiology Leiden University Medical Center Leiden The Netherlands
Leiden Institute for Brain and Cognition Leiden University Leiden The Netherlands
C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands
-
Clemens Bos corresponding
University Medical Center Utrecht
Affiliation as printed
Center for Image Sciences University Medical Center Utrecht Utrecht The Netherlands
Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands
Cited by 3 stored of 3
3 results
No patents citing this paper on Lens.org (checked 2026-10-11).