Functionalized electrodes embedded in nanopores: read‐out enhancement?

Chemistry - An Asian Journal, vol. 18, pp. e202200916

Abstract

In this review, functionalized nanogaps embedded in nanopores are discussed in view of their high biosensitivity in detecting biomolecules, their length, type, and sequence. Specific focus is given on nanoelectrodes functionalized with tiny nanometer-sized diamond-like particles offering vast functionalization possibilities for gold junction electrodes. This choice of the functionalization, in turn, offers nucleotide-specific binding possibilities improving the detection signals arising from such functionalized electrodes potentially embedded in a nanopore. The review sheds light onto the use and enhancement of the tunnelling recognition in functionalized nanogaps towards sensing DNA nucleotides and mutation detection, providing important input for a practical realization.

Authors 1

1. Maria Fyta corresponding Aachen Computational Biotechnology

   RWTH Aachen University

   Affiliation as printed

   Computational Biotechnology RWTH-Aachen University Worringerweg 3 52072 Aachen Germany

   Computational Biotechnology, RWTH-Aachen University, Worringerweg 3, 52072 Aachen, Germany