Engineering multicellular living systems—a Keystone Symposia report
Annals of the New York Academy of Sciences, vol. 1518, pp. 183–195
Abstract
The ability to engineer complex multicellular systems has enormous potential to inform our understanding of biological processes and disease and alter the drug development process. Engineering living systems to emulate natural processes or to incorporate new functions relies on a detailed understanding of the biochemical, mechanical, and other cues between cells and between cells and their environment that result in the coordinated action of multicellular systems. On April 3-6, 2022, experts in the field met at the Keystone symposium "Engineering Multicellular Living Systems" to discuss recent advances in understanding how cells cooperate within a multicellular system, as well as recent efforts to engineer systems like organ-on-a-chip models, biological robots, and organoids. Given the similarities and common themes, this meeting was held in conjunction with the symposium "Organoids as Tools for Fundamental Discovery and Translation".
Authors 25
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Affiliation as printed
PhD Science Writer New York New York USA
PhD Science Writer, New York, New York, USA
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Broad Institute · Harvard University · Harvard Stem Cell Institute · Stanley Center for Psychiatric Research
Affiliation as printed
Department of Stem Cell and Regenerative Biology Harvard University Cambridge Massachusetts USA
Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard Cambridge Massachusetts USA
Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
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Harvard University · Harvard Stem Cell Institute · Wyss Institute for Biologically Inspired Engineering
Affiliation as printed
Harvard Stem Cell Institute Harvard University Cambridge Massachusetts USA
Wyss Institute for Biologically Inspired Engineering and John A. Paulson School of Engineering and Applied Sciences Harvard University Cambridge Massachusetts USA
Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA
Wyss Institute for Biologically Inspired Engineering and John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA
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Affiliation as printed
Department of Bioengineering, School of Engineering and Applied Science and Department of Cell and Developmental Biology, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA
Department of Bioengineering, School of Engineering and Applied Science and Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Affiliation as printed
Lewis‐Sigler Institute for Integrative Genomics Princeton University Princeton New Jersey USA
Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA
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Christine L. Mummery Aachen Department of Anatomy and Embryology and LUMC hiPSC Hotel Leiden University Medical Center Leiden the Netherlands Department of Anatomy and Embryology and LUMC hiPSC Hotel
Leiden University Medical Center
Affiliation as printed
Department of Anatomy and Embryology and LUMC hiPSC Hotel Leiden University Medical Center Leiden the Netherlands
Department of Anatomy and Embryology and LUMC hiPSC Hotel, Leiden University Medical Center, Leiden, the Netherlands
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Massachusetts Institute of Technology
Affiliation as printed
Department of Mechanical Engineering and Department of Biological Engineering Massachusetts Institute of Technology Cambridge Massachusetts USA
Department of Mechanical Engineering and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
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Affiliation as printed
Translational Biology Biogen Cambridge Massachusetts USA
Translational Biology, Biogen, Cambridge, Massachusetts, USA
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National Institutes of Health · National Center for Advancing Translational Sciences
Affiliation as printed
National Center for Advancing Translational Sciences National Institutes of Health Bethesda Maryland USA
National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA
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Affiliation as printed
Hubrecht Organoid Technology (HUB) Utrecht the Netherlands
Hubrecht Organoid Technology (HUB), Utrecht, the Netherlands
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Massachusetts Institute of Technology
Affiliation as printed
Department of Chemical Engineering Massachusetts Institute of Technology Cambridge Massachusetts USA
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
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Japan Science and Technology Agency · RIKEN Center for Biosystems Dynamics Research
Affiliation as printed
Laboratory for Developmental Morphogeometry RIKEN Center for Biosystems Dynamics Research Kobe Japan
Precursory Research for Embryonic Science and Technology (PRESTO) Program Japan Science and Technology Agency Kawaguchi Japan
Laboratory for Developmental Morphogeometry, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan
Precursory Research for Embryonic Science and Technology (PRESTO) Program, Japan Science and Technology Agency, Kawaguchi, Japan
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Georgia Institute of Technology · Emory University · The Wallace H. Coulter Department of Biomedical Engineering
Affiliation as printed
The Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University Atlanta Georgia USA
The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA
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Georgia Institute of Technology · Emory University · The Wallace H. Coulter Department of Biomedical Engineering
Affiliation as printed
The Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University Atlanta Georgia USA
The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA
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University of Wisconsin–Madison · University of Houston
Affiliation as printed
Department of Biomedical Engineering and HEALTH Research Institute University of Houston Houston Texas USA
Wisconsin Institute of Discovery and Department of Medical Microbiology & Immunology University of Wisconsin‐Madison Madison Wisconsin USA
Department of Biomedical Engineering and HEALTH Research Institute, University of Houston, Houston, Texas, USA
Wisconsin Institute of Discovery and Department of Medical Microbiology & Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA
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Draper Laboratory · Harvard University · Wyss Institute for Biologically Inspired Engineering
Affiliation as printed
Draper Laboratory Biological Engineering Division Cambridge Massachusetts USA
Wyss Institute for Biologically Inspired Engineering and John A. Paulson School of Engineering and Applied Sciences Harvard University Cambridge Massachusetts USA
Draper Laboratory, Biological Engineering Division, Cambridge, Massachusetts, USA
Wyss Institute for Biologically Inspired Engineering and John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA
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University of Illinois Urbana-Champaign
Affiliation as printed
Beckman Institute for Advanced Science and Technology Urbana Illinois USA
Holonyak Micro & Nanotechnology Laboratory, Department of Electrical and Computer Engineering and Department of Bioengineering University of Illinois Urbana‐Champaign Urbana Illinois USA
Beckman Institute for Advanced Science and Technology, Urbana, Illinois, USA
Holonyak Micro & Nanotechnology Laboratory, Department of Electrical and Computer Engineering and Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, Illinois, USA
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Affiliation as printed
Department of Biomedical Engineering and Department of Materials Science & Engineering Carnegie Mellon University Pittsburgh Pennsylvania USA
Department of Biomedical Engineering and Department of Materials Science & Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
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Affiliation as printed
Department of Chemical Engineering Stanford University Stanford California USA
Department of Chemical Engineering, Stanford University, Stanford, California, USA
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Affiliation as printed
Department of Biomedical Engineering Yale University New Haven Connecticut USA
Department of Biomedical Engineering, Yale University, New Haven, Connecticut, USA
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University of Colorado Boulder
Affiliation as printed
BioFrontiers Institute and Department of Chemical and Biological Engineering University of Colorado Boulder Boulder Colorado USA
BioFrontiers Institute and Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, Colorado, USA
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Institute for Bioengineering of Catalonia
Affiliation as printed
Institute for Bioengineering of Catalonia Catalonia Spain
Institute for Bioengineering of Catalonia, Catalonia, Spain
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Massachusetts General Hospital
Affiliation as printed
Nephrology Division Massachusetts General Hospital Boston Massachusetts USA
Nephrology Division, Massachusetts General Hospital, Boston, Massachusetts, USA
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Gladstone Institutes · University of California, San Francisco
Affiliation as printed
The Gladstone Institutes and Department of Bioengineering and Therapeutic Sciences University of California San Francisco San Francisco California USA
The Gladstone Institutes and Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA
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Adriana Mulero‐Russe corresponding
Georgia Institute of Technology
Affiliation as printed
Parker H. Petit Institute for Bioengineering and Bioscience and School of Chemical and Biomolecular Engineering Georgia Institute of Technology Atlanta Georgia USA
Parker H. Petit Institute for Bioengineering and Bioscience and School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA
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