Interactive Hemocompatible Nanocoating to Prevent Surface‐Induced Coagulation in Medical Devices

Advanced Materials Interfaces, vol. 9

Abstract

Abstract Interfacing blood with any artificial surface instantly triggers the activation of coagulation at the interface, posing a risk of adverse thromboembolic complications. Immediately upon contact, blood proteins adsorb to the surface turning it into an active prothrombogenic and proinflammatory interface promoting the activation of platelets and the coagulation cascade. Here, an interactive hemocompatible nanocoating is designed that synergistically combines antifouling polymer brushes with the activity of an anti‐FXIIa antibody to tackle the two main causes of surface‐induced coagulation. The brushes provide a passive layer rendering the surface stealth and non‐thrombogenic against blood activation. Furthermore, as soon as traces of FXIIa arise, the coating immediately and specifically scavenges it, thus actively switching‐off contact activation right at the beginning. Moreover, a means is developed to translate this coating to a broad range of polymeric surfaces commonly used in medical devices. The coated surfaces prevent protein adsorption and provide a barrier to bacterial colonization while being capable of capturing biologically relevant concentrations of FXIIa. Notably, the coating completely prevents the formation of clots on the surface when exposed to blood. Thus, the interactive anti‐FXIIa nanocoating provides a new avenue to improve the hemocompatibility of medical devices in a safe and efficient manner.

Authors 9

1. Jonas Quandt Aachen Institute of Technical and Macromolecular Chemistry

   DWI – Leibniz Institute for Interactive Materials · RWTH Aachen University

   Affiliation as printed

   DWI – Leibniz Institute for Interactive Materials Forckenbeckstraße 50 D‐52074 Aachen Germany

   Institute of Technical and Macromolecular Chemistry RWTH Aachen University D‐52074 Aachen Germany

   Institute of Technical and Macromolecular Chemistry RWTH Aachen University D‐52074 Aachen Germany

   Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, D-52074 Aachen, Germany

2. Manuela Garay‐Sarmiento Aachen Chair of Biotechnology

   DWI – Leibniz Institute for Interactive Materials · RWTH Aachen University

   Affiliation as printed

   Chair of Biotechnology RWTH Aachen University D‐52074 Aachen Germany

   DWI – Leibniz Institute for Interactive Materials Forckenbeckstraße 50 D‐52074 Aachen Germany

   Chair of Biotechnology RWTH Aachen University D‐52074 Aachen Germany

   DWI – Leibniz Institute for Interactive Materials Forckenbeckstraße 50 D‐52074 Aachen Germany

3. Lena Witzdam Aachen Institute of Technical and Macromolecular Chemistry

   DWI – Leibniz Institute for Interactive Materials · RWTH Aachen University

   Affiliation as printed

   DWI – Leibniz Institute for Interactive Materials Forckenbeckstraße 50 D‐52074 Aachen Germany

   Institute of Technical and Macromolecular Chemistry RWTH Aachen University D‐52074 Aachen Germany

   Institute of Technical and Macromolecular Chemistry RWTH Aachen University D‐52074 Aachen Germany

   Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, D-52074 Aachen, Germany

4. Jenny Englert Aachen Chair of Biotechnology

   DWI – Leibniz Institute for Interactive Materials · RWTH Aachen University

   Affiliation as printed

   Chair of Biotechnology RWTH Aachen University D‐52074 Aachen Germany

   DWI – Leibniz Institute for Interactive Materials Forckenbeckstraße 50 D‐52074 Aachen Germany

   Chair of Biotechnology RWTH Aachen University D‐52074 Aachen Germany

   DWI – Leibniz Institute for Interactive Materials Forckenbeckstraße 50 D‐52074 Aachen Germany

5. Yannik Rutsch Aachen Institute of Technical and Macromolecular Chemistry

   DWI – Leibniz Institute for Interactive Materials · RWTH Aachen University

   Affiliation as printed

   DWI – Leibniz Institute for Interactive Materials Forckenbeckstraße 50 D‐52074 Aachen Germany

   Institute of Technical and Macromolecular Chemistry RWTH Aachen University D‐52074 Aachen Germany

   Institute of Technical and Macromolecular Chemistry RWTH Aachen University D‐52074 Aachen Germany

   Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, D-52074 Aachen, Germany

6. Cornelia Stöcker Aachen

   DWI – Leibniz Institute for Interactive Materials

   Affiliation as printed

   DWI – Leibniz Institute for Interactive Materials Forckenbeckstraße 50 D‐52074 Aachen Germany

   DWI – Leibniz Institute for Interactive Materials Forckenbeckstraße 50 D‐52074 Aachen Germany

7. Fabian Obstals Aachen Institute of Technical and Macromolecular Chemistry

   DWI – Leibniz Institute for Interactive Materials · RWTH Aachen University

   Affiliation as printed

   DWI – Leibniz Institute for Interactive Materials Forckenbeckstraße 50 D‐52074 Aachen Germany

   Institute of Technical and Macromolecular Chemistry RWTH Aachen University D‐52074 Aachen Germany

   Institute of Technical and Macromolecular Chemistry RWTH Aachen University D‐52074 Aachen Germany

   Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, D-52074 Aachen, Germany

8. Oliver Grottke Aachen Department of Anesthesiology

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Anesthesiology RWTH Aachen University Hospital Pauwelsstraße 30 D‐52074 Aachen Germany

   Department of Anesthesiology RWTH Aachen University Hospital Pauwelsstraße 30 D‐52074 Aachen Germany

9. César Rodriguez‐Emmenegger corresponding Aachen

   Institució Catalana de Recerca i Estudis Avançats · DWI – Leibniz Institute for Interactive Materials · Barcelona Institute of Science and Technology · Institute for Bioengineering of Catalonia

   Affiliation as printed

   DWI – Leibniz Institute for Interactive Materials Forckenbeckstraße 50 D‐52074 Aachen Germany

   Institució Catalana de Recerca i Estudis Avançats (ICREA) Passeig Lluís Companys 23 Barcelona 08010 Spain

   Institute for Bioengineering of Catalonia (IBEC) The Barcelona Institute of Science and Technology (BIST) Carrer de Baldiri Reixac, 10, 12 Barcelona 08028 Spain

   Institució Catalana de Recerca i Estudis Avançats (ICREA) Passeig Lluís Companys 23 Barcelona 08010 Spain

   Institute for Bioengineering of Catalonia (IBEC) The Barcelona Institute of Science and Technology (BIST) Carrer de Baldiri Reixac, 10, 12 Barcelona 08028 Spain

   Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Carrer de Baldiri Reixac, 10, 12, Barcelona, 08028 Spain