Cytoarchitectonic, receptor distribution and functional connectivity analyses of the macaque frontal lobe
bioRxiv (Cold Spring Harbor Laboratory)
Abstract
Abstract Based on quantitative cyto- and receptor architectonic analyses, we identified 35 prefrontal areas and introduced a novel subdivision of Walker’s areas 10, 9, 8B and 46. Statistical analysis of receptor densities revealed regional differences in lateral and ventrolateral prefrontal cortex. Since structural and functional organization of subdivisions encompassing areas 46 and 12 demonstrated significant differences in the interareal levels of α 2 receptors. Furthermore, multivariate analysis included receptor fingerprints of previously identified 16 motor areas in the same macaque brains, and revealed five clusters encompassing frontal lobe areas. Based on the functional connectivity analysis, clustered areas showed similar connectivity distribution pattern. In particular, rostrally located areas (in clusters 1-2) were characterized by bigger fingerprints, i.e., higher receptor densities, and stronger regional interconnections. Whereas, more caudal areas (in clusters 3-5) had smaller fingerprints, but showed a widespread connectivity pattern with distant cortical regions. Taken together, present study provides a comprehensive insight into the molecular structure underlying the functional organization of the cortex and, thus, reconcile discrepancies between the structural and functional hierarchical organization of the primate frontal lobe. Finally, our data are publicly available via the EBRAINS and BALSA repositories for the entire scientific community.
Authors 9
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Lucija Rapan corresponding
Affiliation as printed
Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich
Institute of Neuroscience and Medicine (INM-), Research Centre Jülich, Jülich, Germany
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Affiliation as printed
Center for Neural Science, New York University
Center for Neural Science, New York University, New York, New York
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Affiliation as printed
Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich
Institute of Neuroscience and Medicine (INM-), Research Centre Jülich, Jülich, Germany
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Affiliation as printed
Center for the Developing Brain, Child Mind Institute
Center for the Developing Brain, Child Mind Institute, New York, New York
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Affiliation as printed
Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich
Institute of Neuroscience and Medicine (INM-), Research Centre Jülich, Jülich, Germany
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Affiliation as printed
Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich
Institute of Neuroscience and Medicine (INM-), Research Centre Jülich, Jülich, Germany
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Affiliation as printed
Center for Neural Science, New York University
Center for Neural Science, New York University, New York, New York
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Forschungszentrum Jülich · Heinrich Heine University Düsseldorf
Affiliation as printed
C. & O. Vogt Institute for Brain Research, Heinrich-Heine-University
Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich
C. & O. Vogt Institute for Brain Research, Heinrich-Heine-University, 4022 Düsseldorf, Germany
Institute of Neuroscience and Medicine (INM-), Research Centre Jülich, Jülich, Germany
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Nicola Palomero‐Gallagher Aachen Department of Psychiatry, Psychotherapy and Psychosomatics Medical Faculty
Forschungszentrum Jülich · Jülich Aachen Research Alliance · Heinrich Heine University Düsseldorf · RWTH Aachen University
Affiliation as printed
C. & O. Vogt Institute for Brain Research, Heinrich-Heine-University
Department of Psychiatry, Psychotherapy, and Psychosomatics, Medical Faculty
Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich
Department of Psychiatry, Psychotherapy, and Psychosomatics, Medical Faculty, RWTH Aachen, and JARA - Translational Brain Medicine, Aachen, Germany
Institute of Neuroscience and Medicine (INM-), Research Centre Jülich, Jülich, Germany
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