Neutrophil phenotypes and functions in cancer: A consensus statement
The Journal of Experimental Medicine, vol. 219
Abstract
Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however, the field of neutrophils in cancer is comparatively young. Here, we summarize key concepts and current knowledge gaps related to the diverse roles of neutrophils throughout cancer progression. We discuss sources of neutrophil heterogeneity in cancer and provide recommendations on nomenclature for neutrophil states that are distinct in maturation and activation. We address discrepancies in the literature that highlight a need for technical standards that ought to be considered between laboratories. Finally, we review emerging questions in neutrophil biology and innate immunity in cancer. Overall, we emphasize that neutrophils are a more diverse population than previously appreciated and that their role in cancer may present novel unexplored opportunities to treat cancer.
Authors 25
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Institut du cancer Rosalind & Morris Goodman · McGill University
Affiliation as printed
Rosalind and Morris Goodman Cancer Institute, Department of Physiology, McGill University, Montreal, Quebec, Canada 1
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Affiliation as printed
Cellular and Molecular Medicine, University of Bristol, Bristol, UK 2
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Feinstein Institute for Medical Research
Affiliation as printed
Center for Immunology and Inflammation, Feinstein Institutes for Medical Research, Manhasset, NY 3
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Feinstein Institute for Medical Research · Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
Affiliation as printed
5Departments of Molecular Medicine and Pediatrics, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY
Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, Feinstein Institutes for Medical Research, Manhasset, NY 4
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Affiliation as printed
Division of Thoracic Surgery, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 6
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Hebrew University of Jerusalem · Hadassah Medical Center
Affiliation as printed
Hadassah Medical Center, Institute of Pulmonary Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel 7
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Affiliation as printed
Board of Governors Regenerative Medicine Institute and Research Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 8
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Hebrew University of Jerusalem
Affiliation as printed
Department of Developmental Biology and Cancer Research, Hebrew University of Jerusalem, Jerusalem, Israel 9
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Spanish National Centre for Cardiovascular Research · Yale University
Affiliation as printed
Area of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain 11
Vascular Biology and Therapeutics Program and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 10
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University of Wisconsin–Madison
Affiliation as printed
13Department of Pediatrics, University of Wisconsin-Madison, Madison, WI
Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 12
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National Institutes of Health · National Institute of Arthritis and Musculoskeletal and Skin Diseases
Affiliation as printed
Systemic Autoimmunity Branch, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 14
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Affiliation as printed
Tumour-Host Interaction Laboratory, The Francis Crick Institute, London, UK 15
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Memorial Sloan Kettering Cancer Center · Cornell University · Swim Across America · Weill Cornell Medicine
Affiliation as printed
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 18
Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 16
Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 17
Weill Cornell Medical College, New York, NY 19
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Université Libre de Bruxelles · Institut Jules Bordet
Affiliation as printed
Laboratory of Immunobiology, Université Libre de Bruxelles, Gosselies, Belgium 21
Lung Cancer and Immuno-Oncology Laboratory, Bordet Cancer Research Laboratories, Institut Jules Bordet, Université Libre de Bruxelles, Anderlecht, Belgium 20
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Affiliation as printed
Department of Cardiothoracic Surgery, Neuberger Berman Foundation Lung Cancer Research Center, Weill Cornell Medicine, New York, NY 22
Department of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY 23
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University of Geneva · University Hospital of Geneva · Ludwig Cancer Research
Affiliation as printed
AGORA Cancer Research Center, Lausanne, Switzerland 27
Department of Oncology, Geneva University Hospitals, Geneva, Switzerland 26
Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland 24
Ludwig Institute for Cancer Research, Lausanne Branch, Lausanne, Switzerland 25
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Spanish National Centre for Cardiovascular Research
Affiliation as printed
Area of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain 11
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University of Oxford · Kennedy Institute of Rheumatology
Affiliation as printed
University of Oxford, Kennedy Institute of Rheumatology, Oxford, UK 28
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Sanquin · Amsterdam University Medical Centers
Affiliation as printed
Department of Molecular Cell Biology and Immunology, Amsterdam University Medical Center, Amsterdam, Netherlands 30
Laboratory of Immunotherapy, Sanquin Research, Amsterdam, Netherlands 29
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Boston Children's Hospital · Harvard University
Affiliation as printed
Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children’s Hospital and Harvard Medical School, Boston, MA 31
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Feinstein Institute for Medical Research
Affiliation as printed
Center for Immunology and Inflammation, Feinstein Institutes for Medical Research, Manhasset, NY 3
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Max Planck Institute for Infection Biology
Affiliation as printed
Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany 32
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Leiden University · Cold Spring Harbor Laboratory · Leiden University Medical Center · The Netherlands Cancer Institute · Cancer Center at Cold Spring Harbor Laboratory
Affiliation as printed
37Banbury Center meeting organizers, Diverse Functions of Neutrophils in Cancer, Cold Spring Harbor Laboratory, New York, NY
Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, Netherlands 34
Division of Tumour Biology and Immunology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, Netherlands 33
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Cold Spring Harbor Laboratory · Cancer Center at Cold Spring Harbor Laboratory
Affiliation as printed
37Banbury Center meeting organizers, Diverse Functions of Neutrophils in Cancer, Cold Spring Harbor Laboratory, New York, NY
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 35
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University of Calgary · Cold Spring Harbor Laboratory · Cancer Center at Cold Spring Harbor Laboratory
Affiliation as printed
37Banbury Center meeting organizers, Diverse Functions of Neutrophils in Cancer, Cold Spring Harbor Laboratory, New York, NY
38Department of Microbiology, Immunology & Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
39Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada
Department of Pharmacology and Physiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada 36
Cited by 326 stored of 341
Cited by patents worldwide 1 (Lens.org)
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