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March 11, 2022 article Open access Aachen paper

Tuning the Elasticity of Nanogels Improves Their Circulation Time by Evading Immune Cells

Angewandte Chemie, vol. 134

DOI: 10.1002/ange.202116653 Full text (OA) OpenAlex

Abstract

Abstract Peptide receptor radionuclide therapy is used to treat solid tumors by locally delivering radiation. However, due to nephro‐ and hepato‐toxicity, it is limited by its dosage. To amplify radiation damage to tumor cells, radiolabeled nanogels can be used. We show that by tuning the mechanical properties of nanogels significant enhancement in circulation half‐life of the gel could be achieved. We demonstrate why and how small changes in the mechanical properties of the nanogels influence its cellular fate. Nanogels with a storage modulus of 37 kPa were minimally phagocytosed by monocytes and macrophages compared to nanogels with 93 kPa modulus. Using PET/CT a significant difference in the blood circulation time of the nanogels was shown. Computer simulations affirmed the results and predicted the mechanism of cellular uptake of the nanogels. Altogether, this work emphasizes the important role of elasticity even for particles that are inherently soft such as nano‐ or microgels.

Authors 14

  1. Prachi Bharat Desai Aachen DWI-Leibniz-Institute for Interactive Materials e.V

    RWTH Aachen University · DWI – Leibniz Institute for Interactive Materials

    Affiliation as printed

    DWI Leibniz Institute for Interactive Materials e.V RWTH Aachen University Forckenbeckstrasse 50 52074 Aachen Germany

    DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074 Aachen, Germany

  2. Rahul Rimal Aachen DWI-Leibniz-Institute for Interactive Materials e.V

    RWTH Aachen University · DWI – Leibniz Institute for Interactive Materials

    Affiliation as printed

    DWI Leibniz Institute for Interactive Materials e.V RWTH Aachen University Forckenbeckstrasse 50 52074 Aachen Germany

    DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074 Aachen, Germany

  3. Alexandru Florea Aachen Department of Nuclear Medicine

    RWTH Aachen University · Universitätsklinikum Aachen · Maastricht University

    Affiliation as printed

    Department of Nuclear Medicine University Hospital RWTH Aachen Pauwelstraße 30 52074 Aachen Germany

    Department of Radiology and Nuclear Medicine School for Cardiovascular Diseases (CARIM) and School for Oncology (GROW) Maastricht University 6229 HX Maastricht The Netherlands

    Department of Radiology and Nuclear Medicine, School for Cardiovascular Diseases (CARIM) and School for Oncology (GROW), Maastricht University, 6229 HX Maastricht, The Netherlands

  4. Rustam A. Gumerov Aachen DWI-Leibniz-Institute for Interactive Materials e.V

    RWTH Aachen University · DWI – Leibniz Institute for Interactive Materials · Lomonosov Moscow State University

    Affiliation as printed

    DWI Leibniz Institute for Interactive Materials e.V RWTH Aachen University Forckenbeckstrasse 50 52074 Aachen Germany

    Physics Department Lomonosov Moscow State University Leninskie Gory 1–2 119991 Moscow Russian Federation

    DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074 Aachen, Germany

  5. Marta Santi Aachen DWI-Leibniz-Institute for Interactive Materials e.V

    RWTH Aachen University · DWI – Leibniz Institute for Interactive Materials

    Affiliation as printed

    DWI Leibniz Institute for Interactive Materials e.V RWTH Aachen University Forckenbeckstrasse 50 52074 Aachen Germany

    DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074 Aachen, Germany

  6. Anastasia S. Sorokina

    Lomonosov Moscow State University

    Affiliation as printed

    Physics Department Lomonosov Moscow State University Leninskie Gory 1–2 119991 Moscow Russian Federation

  7. Sabri E. M. Sahnoun Aachen Department of Nuclear Medicine

    RWTH Aachen University · Universitätsklinikum Aachen

    Affiliation as printed

    Department of Nuclear Medicine University Hospital RWTH Aachen Pauwelstraße 30 52074 Aachen Germany

  8. Thorsten Fischer Aachen DWI-Leibniz-Institute for Interactive Materials e.V

    RWTH Aachen University · DWI – Leibniz Institute for Interactive Materials

    Affiliation as printed

    DWI Leibniz Institute for Interactive Materials e.V RWTH Aachen University Forckenbeckstrasse 50 52074 Aachen Germany

    DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074 Aachen, Germany

  9. Felix Manuel Mottaghy Aachen Department of Nuclear Medicine

    RWTH Aachen University · Universitätsklinikum Aachen · Maastricht University

    Affiliation as printed

    Department of Nuclear Medicine University Hospital RWTH Aachen Pauwelstraße 30 52074 Aachen Germany

    Department of Radiology and Nuclear Medicine School for Cardiovascular Diseases (CARIM) and School for Oncology (GROW) Maastricht University 6229 HX Maastricht The Netherlands

    Department of Radiology and Nuclear Medicine, School for Cardiovascular Diseases (CARIM) and School for Oncology (GROW), Maastricht University, 6229 HX Maastricht, The Netherlands

  10. Agnieszka Morgenroth Aachen Department of Nuclear Medicine

    RWTH Aachen University · Universitätsklinikum Aachen

    Affiliation as printed

    Department of Nuclear Medicine University Hospital RWTH Aachen Pauwelstraße 30 52074 Aachen Germany

  11. Ahmed Mourran Aachen DWI-Leibniz-Institute for Interactive Materials e.V

    RWTH Aachen University · DWI – Leibniz Institute for Interactive Materials

    Affiliation as printed

    DWI Leibniz Institute for Interactive Materials e.V RWTH Aachen University Forckenbeckstrasse 50 52074 Aachen Germany

    DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074 Aachen, Germany

  12. Igor I. Potemkin Aachen DWI-Leibniz-Institute for Interactive Materials e.V

    RWTH Aachen University · DWI – Leibniz Institute for Interactive Materials · Lomonosov Moscow State University · South Ural State University

    Affiliation as printed

    DWI Leibniz Institute for Interactive Materials e.V RWTH Aachen University Forckenbeckstrasse 50 52074 Aachen Germany

    National Research South Ural State University Chelyabinsk 454080 Russian Federation

    Physics Department Lomonosov Moscow State University Leninskie Gory 1–2 119991 Moscow Russian Federation

    DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074 Aachen, Germany

    Physics Department Lomonosov Moscow State University Leninskie Gory 1–2 119991 Moscow Russian Federation

  13. Martin Möller Aachen DWI-Leibniz-Institute for Interactive Materials e.V

    RWTH Aachen University · DWI – Leibniz Institute for Interactive Materials

    Affiliation as printed

    DWI Leibniz Institute for Interactive Materials e.V RWTH Aachen University Forckenbeckstrasse 50 52074 Aachen Germany

    DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074 Aachen, Germany

  14. Smriti Singh corresponding Aachen DWI-Leibniz-Institute for Interactive Materials e.V

    RWTH Aachen University · DWI – Leibniz Institute for Interactive Materials · Max Planck Institute for Medical Research

    Affiliation as printed

    DWI Leibniz Institute for Interactive Materials e.V RWTH Aachen University Forckenbeckstrasse 50 52074 Aachen Germany

    Max Planck Institute for Medical Research (MPImF) Jahnstrasse 29 69120 Heidelberg Germany

    DWI Leibniz Institute for Interactive Materials e.V, RWTH Aachen University, Forckenbeckstrasse 50, 52074 Aachen, Germany

    Max Planck Institute for Medical Research (MPImF), Jahnstrasse 29, 69120 Heidelberg, Germany

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References 54