Biodegradation and Immunological Parameters of Polyurethane‐Based Tissue Adhesive in Arterial Microvascular Anastomoses—A Long‐Term In Vivo Study
Macromolecular Bioscience, vol. 22, pp. e2100451
Abstract
In microsurgical anastomosis, non-synthetic fibrin-based adhesives have predominantly shown superior properties to synthetic cyanoacrylates, but they have hardly any clinical application. This study aims to investigate the local and systemic effects of synthetically produced biodegradable adhesive VIVO when used in microsurgical anastomosis. VIVO is used in two different anastomosis procedures in the common carotid artery in a rat model: VIVO in addition to a temporary catheter (VIVO TC) and VIVO with a custom-shaped memory nitinol stent (VIVO SM). Conventionally sutured anastomoses serve as controls (C). Tissue response is assessed by in vivo fluorescence imaging and histological examination. The systemic effects of biodegradation are measured using hematologic parameters and serum levels of transaminase activity and lactate dehydrogenase. Finally, the degree of local adhesion of the different anastomotic procedures is evaluated. Fluorescence imaging shows reduced inflammatory blood flow in the VIVO TC group. Histological analysis of the anastomosed vessels also reveals significantly more inflammation in C than in the two adhesive groups. The severity of VIVO adhesions proves acceptable, and no histotoxic effects of VIVO are detected. The data demonstrate that the synthetic tissue adhesive VIVO is a reliable and-compared to sutures-tissue-friendly adhesive for microsurgical anastomoses.
Authors 10
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Affiliation as printed
Department of Oral and Maxillofacial Surgery University Hospital of Aachen Pauwelsstraße 30 52074 Aachen Germany
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Affiliation as printed
Department of Oral and Maxillofacial Surgery University Hospital of Aachen Pauwelsstraße 30 52074 Aachen Germany
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Affiliation as printed
Department of Oral and Maxillofacial Surgery University Hospital of Aachen Pauwelsstraße 30 52074 Aachen Germany
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Witten/Herdecke University · Universitätsklinikum Aachen
Affiliation as printed
Department of Oral and Maxillofacial Surgery University Hospital of Aachen Pauwelsstraße 30 52074 Aachen Germany
Department of Orthodontics University of Witten/Herdecke Alfred‐Herrhausen Str. 45 58455 Witten Germany
Department of Oral and Maxillofacial Surgery University Hospital of Aachen Pauwelsstraße 30 52074 Aachen Germany
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Affiliation as printed
Department of Oral and Maxillofacial Surgery University Hospital of Aachen Pauwelsstraße 30 52074 Aachen Germany
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Affiliation as printed
Institute of Laboratory Animal Science and Experimental Surgery of RWTH‐Aachen Pauwelsstraße 30 52074 Aachen Germany
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Affiliation as printed
Department of Biohybrid and Medical Textiles (BioTex) AME‐Helmholtz Institute for Biomedical Engineering RWTH Aachen University 52074 Aachen Germany
Department of Biohybrid and Medical Textiles (BioTex), AME-Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, 52074 Aachen, Germany
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Affiliation as printed
Campus Melaten Implant Pathology ZBMT Pauwelsstraße 17 52074 Aachen Germany
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Affiliation as printed
Department of Oral and Maxillofacial Surgery University Hospital of Aachen Pauwelsstraße 30 52074 Aachen Germany
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Affiliation as printed
Department of Oral and Maxillofacial Surgery University Hospital of Aachen Pauwelsstraße 30 52074 Aachen Germany
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