Hemostasis and Gingival Healing—Polyurethane Adhesive Postextraction Under Rivaroxaban Therapy in a Rodent Model

International Journal of Dentistry, vol. 2025, pp. 3384210

Abstract

Objectives: At 31%, the risk of postoperative bleeding after tooth extraction is particularly high in patients who receive rivaroxaban therapy. The aim of this rodent study was to compare the hemostyptic properties and gingival healing between novel polyurethane‐based adhesive VIVO and gelatin sponge (GESP) under ongoing rivaroxaban therapy over a period of 10 days. Materials: In total, 120 extractions of the first upper molar were proceeded in rodents treated with rivaroxaban. Of these, 60 postextraction sites were treated with VIVO and 60 with GESP. The duration of the surgical procedure and the clinical parameters of postoperative bleeding and wound evaluation score were recorded. In vivo fluorescence imaging and laser Doppler flowmetry and tissue spectrophotometry (LDF‐TS) were performed. Results: GESP provided a faster procedure at 1:06 ± 0:17 min, but postoperative bleeding time was significantly shorter in VIVO sockets at 1:39 ± 0:03 min. Nonsignificant mild bleeding events and comparable wound evaluation scores were recorded in both treatments. LDF‐TS showed a significant increase in mean oxygen saturation SO 2 (%) and mean blood flow (AU) for both treatments. Only GESP showed a significant increase in relative hemoglobin (rHb). Conclusion: In the context of a rodent study, VIVO showed favorable hemostasis and promising gingival healing properties postextraction under ongoing rivaroxaban therapy.

Authors 8

1. Marius Heitzer corresponding Aachen Department of Oral and Cranio-Maxillofacial Surgery

   RWTH Aachen University

   Affiliation as printed

   Department of Oral and Cranio-Maxillofacial Surgery, Rheinisch-Westfalische Technische Hochschule Aachen, Aachen, Germany

2. Philipp Winnand Aachen Department of Oral and Cranio-Maxillofacial Surgery

   RWTH Aachen University

   Affiliation as printed

   Department of Oral and Cranio-Maxillofacial Surgery, Rheinisch-Westfalische Technische Hochschule Aachen, Aachen, Germany

3. Marie Sophie Katz Aachen Department of Oral and Cranio-Maxillofacial Surgery

   RWTH Aachen University

   Affiliation as printed

   Department of Oral and Cranio-Maxillofacial Surgery, Rheinisch-Westfalische Technische Hochschule Aachen, Aachen, Germany

4. Oliver Grottke Aachen Clinic for Anaesthesiology/Operative Intensive Care Medicine

   RWTH Aachen University

   Affiliation as printed

   Clinic for Anaesthesiology/Operative Intensive Care Medicine, Rheinisch-Westfalische Technische Hochschule Aachen, Aachen, Germany

5. Zuzanna Magnuska Aachen Institute for Experimental Molecular Imaging

   RWTH Aachen University

   Affiliation as printed

   Institute for Experimental Molecular Imaging, Rheinisch-Westfalische Technische Hochschule Aachen, Aachen, Germany

6. Fabian M. Kiessling Aachen Institute for Experimental Molecular Imaging

   RWTH Aachen University

   Affiliation as printed

   Institute for Experimental Molecular Imaging, Rheinisch-Westfalische Technische Hochschule Aachen, Aachen, Germany

7. Frank Hölzle Aachen Department of Oral and Cranio-Maxillofacial Surgery

   RWTH Aachen University

   Affiliation as printed

   Department of Oral and Cranio-Maxillofacial Surgery, Rheinisch-Westfalische Technische Hochschule Aachen, Aachen, Germany

8. Ali Modabber Aachen Department of Oral and Cranio-Maxillofacial Surgery

   RWTH Aachen University

   Affiliation as printed

   Department of Oral and Cranio-Maxillofacial Surgery, Rheinisch-Westfalische Technische Hochschule Aachen, Aachen, Germany