mGluR5 and GABAA receptor‐specific parametric PET atlas construction— PET / MR data processing pipeline, validation, and application
Human Brain Mapping, vol. 43, pp. 2148–2163
Abstract
Abstract The glutamate and γ‐aminobutyric acid neuroreceptor subtypes mGluR5 and GABAA are hypothesized to be involved in the development of a variety of psychiatric diseases. However, detailed information relating to their in vivo distribution is generally unavailable. Maps of such distributions could potentially aid clinical studies by providing a reference for the normal distribution of neuroreceptors and may also be useful as covariates in advanced functional magnetic resonance imaging (MR) studies. In this study, we propose a comprehensive processing pipeline for the construction of standard space, in vivo distributions of non‐displaceable binding potential (BPND), and total distribution volume (VT) based on simultaneously acquired bolus‐infusion positron emission tomography (PET) and MR data. The pipeline was applied to [11C]ABP688‐PET/MR (13 healthy male non‐smokers, 26.6 ± 7.0 years) and [11C]Flumazenil‐PET/MR (10 healthy males, 25.8 ± 3.0 years) data. Activity concentration templates, as well as VT and BPND atlases of mGluR5 and GABAA, were generated from these data. The maps were validated by assessing the percent error δ from warped space to native space in a selection of brain regions. We verified that the average δABP = 3.0 ± 1.0% and δFMZ = 3.8 ± 1.4% were lower than the expected variabilities σ of the tracers (σABP = 4.0%–16.0%, σFMZ = 3.9%–9.5%). An evaluation of PET‐to‐PET registrations based on the new maps showed higher registration accuracy compared to registrations based on the commonly used [15O]H2O‐template distributed with SPM12. Thus, we conclude that the resulting maps can be used for further research and the proposed pipeline is a viable tool for the construction of standardized PET data distributions.
Authors 18
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RWTH Aachen University · Forschungszentrum Jülich
Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics RWTH Aachen University Aachen Germany
Forschungszentrum Jülich Institute of Neuroscience and Medicine 4, INM‐4 Jülich Germany
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany
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RWTH Aachen University · Forschungszentrum Jülich · Jülich Aachen Research Alliance
Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics RWTH Aachen University Aachen Germany
Forschungszentrum Jülich Institute of Neuroscience and Medicine 4, INM‐4 Jülich Germany
JARA BRAIN Translational Medicine Aachen Germany
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany
Forschungszentrum Jülich Institute of Neuroscience and Medicine 4, INM‐4 Jülich Germany
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RWTH Aachen University · Forschungszentrum Jülich · Jülich Aachen Research Alliance
Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics RWTH Aachen University Aachen Germany
Forschungszentrum Jülich Institute of Neuroscience and Medicine 4, INM‐4 Jülich Germany
JARA BRAIN Translational Medicine Aachen Germany
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany
Forschungszentrum Jülich Institute of Neuroscience and Medicine 4, INM‐4 Jülich Germany
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Affiliation as printed
Forschungszentrum Jülich Institute of Neuroscience and Medicine 4, INM‐4 Jülich Germany
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RWTH Aachen University · Forschungszentrum Jülich · Jülich Aachen Research Alliance
Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics RWTH Aachen University Aachen Germany
Forschungszentrum Jülich Institute of Neuroscience and Medicine 4, INM‐4 Jülich Germany
JARA BRAIN Translational Medicine Aachen Germany
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany
Forschungszentrum Jülich Institute of Neuroscience and Medicine 4, INM‐4 Jülich Germany
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RWTH Aachen University · Forschungszentrum Jülich
Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics RWTH Aachen University Aachen Germany
Forschungszentrum Jülich Institute of Neuroscience and Medicine 4, INM‐4 Jülich Germany
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany
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RWTH Aachen University · Forschungszentrum Jülich · Arab American University
Affiliation as printed
Department of Medical Imaging Arab‐American University Palestine Jenin Palestine
Department of Psychiatry, Psychotherapy and Psychosomatics RWTH Aachen University Aachen Germany
Forschungszentrum Jülich Institute of Neuroscience and Medicine 4, INM‐4 Jülich Germany
Department of Psychiatry, Psychotherapy and Psychosomatics RWTH Aachen University Aachen Germany
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany
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University of Zurich · Forschungszentrum Jülich · University Hospital Zurich · Psychiatrische Universitätsklinik Zürich
Affiliation as printed
Department for Psychiatry, Psychotherapy and Psychosomatics Social Psychiatry University Hospital of Psychiatry Zurich Zurich Switzerland
Forschungszentrum Jülich Institute of Neuroscience and Medicine 4, INM‐4 Jülich Germany
Department for Psychiatry, Psychotherapy and Psychosomatics Social Psychiatry, University Hospital of Psychiatry Zurich, Zurich, Switzerland
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Affiliation as printed
Forschungszentrum Jülich Institute of Neuroscience and Medicine 4, INM‐4 Jülich Germany
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Affiliation as printed
Forschungszentrum Jülich Institute of Neuroscience and Medicine 4, INM‐4 Jülich Germany
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Affiliation as printed
Forschungszentrum Jülich Institute of Neuroscience and Medicine 5, INM‐5 Jülich Germany
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Affiliation as printed
Forschungszentrum Jülich Institute of Neuroscience and Medicine 5, INM‐5 Jülich Germany
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Affiliation as printed
Forschungszentrum Jülich Institute of Neuroscience and Medicine 4, INM‐4 Jülich Germany
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RWTH Aachen University · Forschungszentrum Jülich · Jülich Aachen Research Alliance
Affiliation as printed
Department of Nuclear Medicine RWTH Aachen University Aachen Germany
Forschungszentrum Jülich Institute of Neuroscience and Medicine 4, INM‐4 Jülich Germany
JARA BRAIN Translational Medicine Aachen Germany
Department of Nuclear Medicine, RWTH Aachen University, Aachen, Germany
Forschungszentrum Jülich Institute of Neuroscience and Medicine 4, INM‐4 Jülich Germany
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Affiliation as printed
Forschungszentrum Jülich Institute of Neuroscience and Medicine 4, INM‐4 Jülich Germany
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RWTH Aachen University · Forschungszentrum Jülich · Jülich Aachen Research Alliance
Affiliation as printed
Department of Neurology RWTH Aachen University Aachen Germany
Forschungszentrum Jülich Institute of Neuroscience and Medicine 11, INM‐11 Jülich Germany
Forschungszentrum Jülich Institute of Neuroscience and Medicine 4, INM‐4 Jülich Germany
JARA BRAIN Translational Medicine Aachen Germany
Department of Neurology, RWTH Aachen University, Aachen, Germany
Forschungszentrum Jülich Institute of Neuroscience and Medicine 4, INM‐4 Jülich Germany
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Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics RWTH Aachen University Aachen Germany
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany
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RWTH Aachen University · Forschungszentrum Jülich · Jülich Aachen Research Alliance
Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics RWTH Aachen University Aachen Germany
Forschungszentrum Jülich Institute of Neuroscience and Medicine 4, INM‐4 Jülich Germany
JARA BRAIN Translational Medicine Aachen Germany
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany
Forschungszentrum Jülich Institute of Neuroscience and Medicine 4, INM‐4 Jülich Germany
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