mGluR5 binding changes during a mismatch negativity task in a multimodal protocol with [11C]ABP688 PET/MR-EEG
Translational Psychiatry, vol. 12, pp. 6
Abstract
Abstract Currently, the metabotropic glutamate receptor 5 (mGluR5) is the subject of several lines of research in the context of neurology and is of high interest as a target for positron-emission tomography (PET). Here, we assessed the feasibility of using [11C]ABP688, a specific antagonist radiotracer for an allosteric site on the mGluR5, to evaluate changes in glutamatergic neurotransmission through a mismatch-negativity (MMN) task as a part of a simultaneous and synchronized multimodal PET/MR-EEG study. We analyzed the effect of MMN by comparing the changes in nondisplaceable binding potential (BPND) prior to (baseline) and during the task in 17 healthy subjects by applying a bolus/infusion protocol. Anatomical and functional regions were analyzed. A small change in BPND was observed in anatomical regions (posterior cingulate cortex and thalamus) and in a functional network (precuneus) after the start of the task. The effect size was quantified using Kendall’s W value and was 0.3. The motor cortex was used as a control region for the task and did not show any significant BPND changes. There was a significant ΔBPND between acquisition conditions. On average, the reductions in binding across the regions were - 8.6 ± 3.2% in anatomical and - 6.4 ± 0.5% in the functional network (p ≤ 0.001). Correlations between ΔBPND and EEG latency for both anatomical (p = 0.008) and functional (p = 0.022) regions were found. Exploratory analyses suggest that the MMN task played a role in the glutamatergic neurotransmission, and mGluR5 may be indirectly modulated by these changes.
Authors 26
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Cláudia Régio Brambilla corresponding Aachen Department of Psychiatry, Psychotherapy and Psychosomatics
Forschungszentrum Jülich · RWTH Aachen University
Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany. c.regio.brambilla@fz-juelich.de
Institute of Neuroscience and Medicine, INM-4, Forschungszentrum Jülich GmbH, Jülich, Germany. c.regio.brambilla@fz-juelich.de
Institute of Neuroscience and Medicine, INM-4, Forschungszentrum Jülich GmbH, Jülich, Germany
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Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany
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Forschungszentrum Jülich · RWTH Aachen University
Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany
Institute of Neuroscience and Medicine, INM-4, Forschungszentrum Jülich GmbH, Jülich, Germany
JARA - BRAIN - Translational Medicine, Aachen, Germany
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Affiliation as printed
Institute of Neuroscience and Medicine, INM-4, Forschungszentrum Jülich GmbH, Jülich, Germany
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Affiliation as printed
Institute of Neuroscience and Medicine, INM-2, Forschungszentrum Jülich GmbH, Jülich, Germany
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Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany
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Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany
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Forschungszentrum Jülich · RWTH Aachen University
Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany
Institute of Neuroscience and Medicine, INM-4, Forschungszentrum Jülich GmbH, Jülich, Germany
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Forschungszentrum Jülich · RWTH Aachen University
Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany
Institute of Neuroscience and Medicine, INM-4, Forschungszentrum Jülich GmbH, Jülich, Germany
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Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany
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Affiliation as printed
Institute of Neuroscience and Medicine, INM-4, Forschungszentrum Jülich GmbH, Jülich, Germany
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University Hospital Zurich · Psychiatrische Universitätsklinik Zürich
Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry, Zurich, Switzerland
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University Hospital Zurich · LVR-Klinik Köln · Psychiatrische Universitätsklinik Zürich
Affiliation as printed
Department of Psychiatry and Psychotherapy I, LVR-Hospital, Cologne, Germany
Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry, Zurich, Switzerland
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University Hospital Zurich · Clienia AG · Psychiatrische Universitätsklinik Zürich
Affiliation as printed
Clienia Schlössli AG, Oetwil am See, Zurich, Switzerland
Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry, Zurich, Switzerland
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Affiliation as printed
Institute of Neuroscience and Medicine, INM-4, Forschungszentrum Jülich GmbH, Jülich, Germany
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Affiliation as printed
Institute of Neuroscience and Medicine, INM-4, Forschungszentrum Jülich GmbH, Jülich, Germany
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Affiliation as printed
Institute of Neuroscience and Medicine, INM-4, Forschungszentrum Jülich GmbH, Jülich, Germany
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Affiliation as printed
Institute of Neuroscience and Medicine, INM-4, Forschungszentrum Jülich GmbH, Jülich, Germany
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Affiliation as printed
Institute of Neuroscience and Medicine, INM-5, Forschungszentrum Jülich GmbH, Jülich, Germany
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Affiliation as printed
Institute of Neuroscience and Medicine, INM-5, Forschungszentrum Jülich GmbH, Jülich, Germany
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Affiliation as printed
Institute of Neuroscience and Medicine, INM-5, Forschungszentrum Jülich GmbH, Jülich, Germany
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Affiliation as printed
Institute of Neuroscience and Medicine, INM-4, Forschungszentrum Jülich GmbH, Jülich, Germany
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Forschungszentrum Jülich · Jülich Aachen Research Alliance · RWTH Aachen University
Affiliation as printed
Department of Nuclear Medicine, RWTH Aachen University, Aachen, Germany
Institute of Neuroscience and Medicine, INM-4, Forschungszentrum Jülich GmbH, Jülich, Germany
JARA - BRAIN - Translational Medicine, Aachen, Germany
JARA – BRAIN – Translational Medicine, Aachen, Germany
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Forschungszentrum Jülich · Jülich Aachen Research Alliance · RWTH Aachen University
Affiliation as printed
Department of Neurology, RWTH Aachen University, Aachen, Germany
Institute of Neuroscience and Medicine, INM-11, Forschungszentrum Jülich GmbH, Jülich, Germany
Institute of Neuroscience and Medicine, INM-4, Forschungszentrum Jülich GmbH, Jülich, Germany
JARA - BRAIN - Translational Medicine, Aachen, Germany
JARA – BRAIN – Translational Medicine, Aachen, Germany
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Affiliation as printed
Institute of Neuroscience and Medicine, INM-4, Forschungszentrum Jülich GmbH, Jülich, Germany
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Forschungszentrum Jülich · Jülich Aachen Research Alliance · RWTH Aachen University
Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany
Institute of Neuroscience and Medicine, INM-4, Forschungszentrum Jülich GmbH, Jülich, Germany
JARA - BRAIN - Translational Medicine, Aachen, Germany
JARA – BRAIN – Translational Medicine, Aachen, Germany
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