Future prospects for image-derived input function in molecular imaging quantification with the 7 T MR-BrainPET insert

Frontiers in Neuroscience, vol. 19, pp. 1725728

Abstract

Positron emission tomography (PET) and magnetic resonance imaging (MRI) offer complementary information about the human brain in health and disease. The simultaneous 7 T MR-BrainPET insert enables molecular imaging quantification beyond the current limits. Here we present the current status of the field highlighting PET/MR synergies for the image-derived input function (IDIF). We also discuss promising applications that will benefit from these advancements, as well the challenges to be addressed in the near future.

Authors 10

1. Cláudia Régio Brambilla corresponding

   Forschungszentrum Jülich

   Affiliation as printed

   Medical Imaging Physics, Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich GmbH, Jülich, Germany

2. Julia Hilgers

   Forschungszentrum Jülich

   Affiliation as printed

   Medical Imaging Physics, Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich GmbH, Jülich, Germany

3. Usman Khalid

   Forschungszentrum Jülich

   Affiliation as printed

   Medical Imaging Physics, Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich GmbH, Jülich, Germany

4. Ninea Anasovi

   Agricultural University of Georgia

   Affiliation as printed

   Engineering, Agricultural University of Georgia, Tbilisi, Georgia

5. Tornike Kikacheishvili

   Georgian American University

   Affiliation as printed

   Informatics and Engineering School, Georgian American University, Tbilisi, Georgia

6. Jörg Mauler

   Forschungszentrum Jülich

   Affiliation as printed

   Medical Imaging Physics, Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich GmbH, Jülich, Germany

7. Changhoon Choi

   Forschungszentrum Jülich

   Affiliation as printed

   Medical Imaging Physics, Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich GmbH, Jülich, Germany

8. Jürgen J Scheins

   Forschungszentrum Jülich

   Affiliation as printed

   Medical Imaging Physics, Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich GmbH, Jülich, Germany

9. Nadim Jon Shah Aachen Department of Neurology

   Forschungszentrum Jülich · Jülich Aachen Research Alliance · RWTH Aachen University

   Affiliation as printed

   Department of Neurology, RWTH Aachen University, Aachen, Germany

   Institute of Neuroscience and Medicine 11, INM-11, Forschungszentrum Jülich GmbH, Jülich, Germany

   JARA-BRAIN, Aachen, Germany

   Medical Imaging Physics, Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich GmbH, Jülich, Germany

10. Christoph W. Lerche

    Forschungszentrum Jülich

    Affiliation as printed

    Medical Imaging Physics, Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich GmbH, Jülich, Germany