Bioinformatics of virus taxonomy: foundations and tools for developing sequence-based hierarchical classification

Current Opinion in Virology, vol. 52, pp. 48–56

Abstract

The genome sequence is the only characteristic readily obtainable for all known viruses, underlying the growing role of comparative genomics in organizing knowledge about viruses in a systematic evolution-aware way, known as virus taxonomy. Overseen by the International Committee on Taxonomy of Viruses (ICTV), development of virus taxonomy involves taxa demarcation at 15 ranks of a hierarchical classification, often in host-specific manner. Outside the ICTV remit, researchers assess fitting numerous unclassified viruses into the established taxa. They employ different metrics of virus clustering, basing on conserved domain(s), separation of viruses in rooted phylogenetic trees and pair-wise distance space. Computational approaches differ further in respect to methodology, number of ranks considered, sensitivity to uneven virus sampling, and visualization of results. Advancing and using computational tools will be critical for improving taxa demarcation across the virosphere and resolving rank origins in research that may also inform experimental virology.

Authors 2

1. Alexander E. Gorbalenya corresponding Aachen Department of Medical Microbiology

   Leiden University Medical Center · Lomonosov Moscow State University

   Affiliation as printed

   Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands; Faculty of Bioengineering and Bioinformatics and Belozersky, Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119899, Moscow, Russia. Electronic address: a.e.gorbalenya@lumc.nl

   Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

   Faculty of Bioengineering and Bioinformatics and Belozersky, Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119899, Moscow, Russia

2. Chris Lauber

   Medizinische Hochschule Hannover · Helmholtz Centre for Infection Research · Center for Experimental and Clinical Infection Research

   Affiliation as printed

   Institute for Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research, A Joint Venture between the Hannover Medical School (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany