The cAMP responsive element modulator (CREM) is a regulator of CD4 + T cell function

Biological Chemistry, vol. 402, pp. 1591–1596

Abstract

Abstract The cAMP responsive element modulator (CREM) is a transcriptional regulator of different effector cytokines in CD4 + T cells including IL-2, IL-17, IL-21 but also IL-4 and IL-13 and thus an important determinant of central T helper cell functions. Our review gives an overview over the regulation of CREM in T cells and the pleiotropic effects of CREM on CD4 + T cells in health and autoimmune diseases with a particular focus on systemic lupus erythematosus.

Authors 2

1. Sudheendra Hebbar Subramanyam Aachen Department of Pediatrics, Pediatric Pneumology

   RWTH Aachen University

   Affiliation as printed

   Department of Pediatrics , Pediatric Pneumology, Allergology and Immunology, RWTH Aachen University , Aachen , Germany

2. Klaus Tenbrock corresponding Aachen Department of Pediatrics, Pediatric Pneumology

   RWTH Aachen University · University of Münster

   Affiliation as printed

   Department of Pediatrics , Pediatric Pneumology, Allergology and Immunology, RWTH Aachen University , Aachen , Germany

   Interdisciplinary Center for Clinical Research IZKF , Aachen , Germany

   Interdisciplinary Center for Clinical Research IZKF , Münster , Germany