School performance and behavioral functioning in children after intrauterine transfusions for hemolytic disease of the fetus and newborn

Early Human Development, vol. 157, pp. 105381

Abstract

AIM: To investigate the school performance and behavioral difficulties in children with hemolytic disease of the fetus and newborn (HDFN) treated with intrauterine transfusion (IUT) compared to Dutch norm data. STUDY DESIGN: Cros-sectional cohort study. SUBJECTS: Children who received one or multiple IUTs for severe Rh- or K (Kell)-mediated HDFN between January 2008 and January 2015 at the LUMC. OUTCOME MEASURES: School performance reports were assessed as well as behavioral difficulties as assessed with the Dutch child behavioral checklist (CBCL) by parents and caregivers and the Teacher Report Form (TRF) completed by teachers. RESULTS: A response rate of 56% (70 children, aged 5-12 years) was obtained. Grade repetition occurred in 13 cases (19%), 16 children (23%) received some form of additional help, most often support by a speech therapist (n = 8), but also support for dyslexia (n = 4), physical therapy (n = 2) and social-emotional support (n = 2). None of the children in our study group attended special-needs education. School performance levels for reading comprehension, spelling and mathematics according to the Dutch National Pupil Monitoring System were similar for the study population and Dutch norm data. The incidence of behavioral problems as reported by parents was similar to the Dutch norm data, teachers reported less behavioral difficulties in the study group. CONCLUSION: This study shows favorable and reassuring school development in children treated with IUT in an experienced fetal-therapy center. A normal distribution in school and behavioral development is to be expected for children with HDFN treated with IUTs.

Authors 6

1. Isabelle M. C. Ree corresponding Aachen Department of Pediatrics Division of Neonatology, Leiden University Medical Center

   Leiden University Medical Center · Sanquin · Jon J van Rood Centre for Clinical Transfusion Research

   Affiliation as printed

   Center for Clinical Transfusion Research, Sanquin Research, Leiden, the Netherlands; Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: i.m.c.ree@lumc.nl

   Center for Clinical Transfusion Research, Sanquin Research, Leiden, the Netherlands

   Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, the Netherlands

2. Renske Marijke van 't Oever Aachen Department of Pediatrics Division of Neonatology, Leiden University Medical Center

   Leiden University Medical Center

   Affiliation as printed

   Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, the Netherlands

3. Lisette Jansen Aachen Department of Medical Psychology

   Leiden University Medical Center

   Affiliation as printed

   Department of Medical Psychology, Leiden University Medical Center, the Netherlands

4. Enrico Lopriore Aachen Department of Pediatrics Division of Neonatology, Leiden University Medical Center

   Leiden University Medical Center

   Affiliation as printed

   Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, the Netherlands

5. Masja de Haas Aachen Department of Hematology, Leiden University Medical Center

   Leiden University Medical Center · Sanquin · Jon J van Rood Centre for Clinical Transfusion Research

   Affiliation as printed

   Center for Clinical Transfusion Research, Sanquin Research, Leiden, the Netherlands; Department of Hematology, Leiden University Medical Center, Leiden, the Netherlands; Department of Immunohematology Diagnostics, Sanquin, Amsterdam, the Netherlands

   Center for Clinical Transfusion Research, Sanquin Research, Leiden, the Netherlands

   Department of Hematology, Leiden University Medical Center, Leiden, the Netherlands

   Department of Immunohematology Diagnostics, Sanquin, Amsterdam, the Netherlands

6. Jeanine M.M. van Klink Aachen Department of Medical Psychology

   Leiden University Medical Center

   Affiliation as printed

   Department of Medical Psychology, Leiden University Medical Center, the Netherlands