Controlling Structure with Injectable Biomaterials to Better Mimic Tissue Heterogeneity and Anisotropy
Advanced Healthcare Materials, vol. 10, pp. e2002221
Abstract
Tissue regeneration of sensitive tissues calls for injectable scaffolds, which are minimally invasive and offer minimal damage to the native tissues. However, most of these systems are inherently isotropic and do not mimic the complex hierarchically ordered nature of the native extracellular matrices. This review focuses on the different approaches developed in the past decade to bring in some form of anisotropy to the conventional injectable tissue regenerative matrices. These approaches include introduction of macroporosity, in vivo pattering to present biomolecules in a spatially and temporally controlled manner, availability of aligned domains by means of self-assembly or oriented injectable components, and in vivo bioprinting to obtain structures with features of high resolution that resembles native tissues. Toward the end of the review, different techniques to produce building blocks for the fabrication of heterogeneous injectable scaffolds are discussed. The advantages and shortcomings of each approach are discussed in detail with ideas to improve the functionality and versatility of the building blocks.
Authors 4
-
Susan Babu Aachen Institute of Technical and Macromolecular Chemistry (ITMC) Polymeric Biomaterials DWI - Leibniz Institute for Interactive Materials Institute of Technical and Macromolecular Chemistry
DWI – Leibniz Institute for Interactive Materials · Max Planck School Matter to Life · RWTH Aachen University
Affiliation as printed
DWI‐Leibniz Institute for Interactive Materials Forckenbeckstrasse 50 Aachen 52074 Germany
Institute of Technical and Macromolecular Chemistry (ITMC) Polymeric Biomaterials RWTH University Aachen Worringerweg 2 Aachen 52074 Germany
Max Planck School‐Matter to Life (MtL) Jahnstrasse 29 Heidelberg 69120 Germany
DWI-Leibniz Institute for Interactive Materials, Forckenbeckstrasse 50, Aachen, 52074 Germany
Institute of Technical and Macromolecular Chemistry (ITMC), Polymeric Biomaterials, RWTH University Aachen, Worringerweg 2, Aachen, 52074 Germany
Max Planck School-Matter to Life (MtL), Jahnstrasse 29, Heidelberg, 69120 Germany
-
DWI – Leibniz Institute for Interactive Materials
Affiliation as printed
DWI‐Leibniz Institute for Interactive Materials Forckenbeckstrasse 50 Aachen 52074 Germany
DWI-Leibniz Institute for Interactive Materials, Forckenbeckstrasse 50, Aachen, 52074 Germany
-
DWI – Leibniz Institute for Interactive Materials
Affiliation as printed
DWI‐Leibniz Institute for Interactive Materials Forckenbeckstrasse 50 Aachen 52074 Germany
DWI-Leibniz Institute for Interactive Materials, Forckenbeckstrasse 50, Aachen, 52074 Germany
-
Laura De Laporte corresponding Aachen Institute of Technical and Macromolecular Chemistry (ITMC) Polymeric Biomaterials Advanced Materials for Biomedicine (AMB) Institute of Applied Medical Engineering Center for Biohybrid Medical Systems (CBMS) DWI - Leibniz Institute for Interactive Materials Institute of Technical and Macromolecular Chemistry
DWI – Leibniz Institute for Interactive Materials · Universitätsklinikum Aachen · Max Planck School Matter to Life · RWTH Aachen University
Affiliation as printed
Advanced Materials for Biomedicine (AMB) Institute of Applied Medical Engineering (AME) Center for Biohybrid Medical Systems (CMBS) University Hospital RWTH Aachen Forckenbeckstrasse 55 Aachen 52074 Germany
DWI‐Leibniz Institute for Interactive Materials Forckenbeckstrasse 50 Aachen 52074 Germany
Institute of Technical and Macromolecular Chemistry (ITMC) Polymeric Biomaterials RWTH University Aachen Worringerweg 2 Aachen 52074 Germany
Max Planck School‐Matter to Life (MtL) Jahnstrasse 29 Heidelberg 69120 Germany
Advanced Materials for Biomedicine (AMB), Institute of Applied Medical Engineering (AME), Center for Biohybrid Medical Systems (CMBS), University Hospital RWTH Aachen, Forckenbeckstrasse 55, Aachen, 52074 Germany
DWI-Leibniz Institute for Interactive Materials, Forckenbeckstrasse 50, Aachen, 52074 Germany
Institute of Technical and Macromolecular Chemistry (ITMC), Polymeric Biomaterials, RWTH University Aachen, Worringerweg 2, Aachen, 52074 Germany
Max Planck School-Matter to Life (MtL), Jahnstrasse 29, Heidelberg, 69120 Germany
Cited by 54 stored of 55
No patents citing this paper on Lens.org (checked 2026-10-06).