Time‐encoded golden angle radial arterial spin labeling: Simultaneous acquisition of angiography and perfusion data

NMR in Biomedicine, vol. 34, pp. e4519

Abstract

The objective of the current study was to combine a time-encoded pseudocontinuous arterial spin labeling (te-pCASL) scheme with a golden angle radial readout for simultaneous acquisition of angiography and perfusion images from one single dataset, both in a highly flexible single-slice approach as well as within a multislice setting. A te-pCASL preparation and the golden angle radial readout were both used as a temporal resolution tool to retrospectively choose the temporal window for the reconstruction of both angiography and perfusion images from a single-slice dataset. The temporal window could be chosen retrospectively and adjusted to the hemodynamics of the volunteer on the scanner for the single-slice dataset. Angiographic images were reconstructed at a minimum temporal resolution of 69 ms. For the perfusion phase, only the densely sampled center of k-space was included in the reconstruction. For a multislice acquisition, the golden angle radial readout allowed reconstruction of images with different spatial resolutions to provide angiographic and perfusion information over 10 slices. The te-pCASL preparation was used as the only source for dynamic information. The multislice acquisition shows the ability of the golden angle radial readout to display the inflow of the labeled blood into the arteries as well as the perfusion in the tissue with full brain coverage. By combining a te-pCASL preparation with a golden angle radial readout, single-slice high temporal resolution angiography and good quality perfusion images were reconstructed in a flexible manner from a single dataset. Optimizing the golden angle radial readout for reconstructions at multiple spatial resolutions allows for multislice acquisition.

Authors 5

1. Merlijn C. E. van der Plas corresponding Aachen C.J. Gorter Center for High Field MRI Department of Radiology Leiden University Medical Center Leiden The Netherlands

   Leiden University Medical Center

   Affiliation as printed

   C. J. Gorter Center for High Field MRI, Department of Radiology Leiden University Medical Center Leiden the Netherlands

   Leiden Institute of Brain and Cognition (LIBC) Leiden University Medical Center Leiden the Netherlands

   C. J. Gorter Center for High Field MRI, Department of Radiology Leiden University Medical Center Leiden the Netherlands

2. Sophie Schmid Aachen C.J. Gorter Center for High Field MRI Department of Radiology Leiden University Medical Center Leiden The Netherlands

   Leiden University Medical Center

   Affiliation as printed

   C. J. Gorter Center for High Field MRI, Department of Radiology Leiden University Medical Center Leiden the Netherlands

   Leiden Institute of Brain and Cognition (LIBC) Leiden University Medical Center Leiden the Netherlands

   C. J. Gorter Center for High Field MRI, Department of Radiology Leiden University Medical Center Leiden the Netherlands

3. Maarten J. Versluis

   Philips (Netherlands)

   Affiliation as printed

   Phillips Healthcare Best the Netherlands

   Phillips Healthcare, Best, the Netherlands

4. Thomas W. Okell

   University of Oxford · Wellcome Centre for Integrative Neuroimaging

   Affiliation as printed

   Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences University of Oxford Oxford UK

   Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK

5. Matthias J.P. van Osch Aachen C.J. Gorter Center for High Field MRI Department of Radiology Leiden University Medical Center Leiden The Netherlands

   Leiden University Medical Center

   Affiliation as printed

   C. J. Gorter Center for High Field MRI, Department of Radiology Leiden University Medical Center Leiden the Netherlands

   Leiden Institute of Brain and Cognition (LIBC) Leiden University Medical Center Leiden the Netherlands

   C. J. Gorter Center for High Field MRI, Department of Radiology Leiden University Medical Center Leiden the Netherlands