Memory CD8+ T cell heterogeneity is primarily driven by pathogen-specific cues and additionally shaped by the tissue environment
iScience, vol. 24, pp. 101954
Abstract
Factors that govern the complex formation of memory T cells are not completely understood. A better understanding of the development of memory T cell heterogeneity is however required to enhance vaccination and immunotherapy approaches. Here we examined the impact of pathogen- and tissue-specific cues on memory CD8 + T cell heterogeneity using high-dimensional single-cell mass cytometry and a tailored bioinformatics pipeline. We identified distinct populations of pathogen-specific CD8 + T cells that uniquely connected to a specific pathogen or associated to multiple types of acute and persistent infections. In addition, the tissue environment shaped the memory CD8 + T cell heterogeneity, albeit to a lesser extent than infection. The programming of memory CD8 + T cell differentiation during acute infection is eventually superseded by persistent infection. Thus, the plethora of distinct memory CD8 + T cell subsets that arise upon infection is dominantly sculpted by the pathogen-specific cues and further shaped by the tissue environment.
Authors 9
-
Leiden University Medical Center
Affiliation as printed
Department of Immunology, Leiden University Medical Center, Leiden 2333ZA, the Netherlands
-
Leiden University Medical Center
Affiliation as printed
Department of Immunology, Leiden University Medical Center, Leiden 2333ZA, the Netherlands
-
Leiden University Medical Center · Delft University of Technology
Affiliation as printed
Delft Bioinformatics Lab, Delft University of Technology, Delft 2628XE, the Netherlands
Leiden Computational Biology Center, Leiden University Medical Center, Leiden 2333ZA, the Netherlands
-
Leiden University Medical Center
Affiliation as printed
Department of Immunology, Leiden University Medical Center, Leiden 2333ZA, the Netherlands
-
Leiden University Medical Center
Affiliation as printed
Department of Immunology, Leiden University Medical Center, Leiden 2333ZA, the Netherlands
-
Leiden University Medical Center
Affiliation as printed
Department of Immunology, Leiden University Medical Center, Leiden 2333ZA, the Netherlands
-
Leiden University Medical Center
Affiliation as printed
Department of Immunology, Leiden University Medical Center, Leiden 2333ZA, the Netherlands
-
Leiden University Medical Center
Affiliation as printed
Department of Immunology, Leiden University Medical Center, Leiden 2333ZA, the Netherlands
-
Leiden University Medical Center
Affiliation as printed
Department of Immunology, Leiden University Medical Center, Leiden 2333ZA, the Netherlands
Cited by 11 stored of 11
11 results
No patents citing this paper on Lens.org (checked 2026-10-11).