Dendritic cell circadian clocks shape memory CD8 + T cell differentiation
Science Advances, vol. 12, pp. eaeh3719
Abstract
Circadian rhythms regulate diverse immune processes, yet how they influence memory CD8 + T cell differentiation remains unclear. Here, we show that the time of day of antigen encounter shapes CD8 + T cell fate and antiviral immunity. Immunization during the active phase promotes the generation of progenitor-like memory CD8 + T cells and enhances T cell-mediated protection upon viral challenge. Mechanistically, dendritic cell-intrinsic circadian clocks regulate expression of the costimulatory ligand CD70, thereby directing T cell differentiation. These findings uncover a dendritic cell-mediated circadian mechanism that governs memory T cell fate decisions and suggest that aligning immune priming with circadian time may be leveraged to optimize T cell immunity.
Authors 9
-
Leiden University Medical Center
Affiliation as printed
Department of Immunology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
-
Leiden University Medical Center
Affiliation as printed
Department of Immunology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
-
Leiden University Medical Center
Affiliation as printed
Department of Immunology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
-
Leiden University Medical Center
Affiliation as printed
Department of Immunology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
-
Marissa E. Linger Aachen
Leiden University · Leiden University Medical Center
Affiliation as printed
Leiden University Center for Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
-
Sytze H.T. Jorritsma Aachen
Leiden University · Leiden University Medical Center
Affiliation as printed
Leiden University Center for Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
-
Sebenzile K. Myeni Aachen
Leiden University · Leiden University Medical Center
Affiliation as printed
Leiden University Center for Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
-
Leiden University Medical Center
Affiliation as printed
Department of Cell and Chemical Biology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands
-
Leiden University Medical Center
Affiliation as printed
Department of Immunology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Cited by 0 stored of 0
No patents citing this paper on Lens.org (checked 2026-10-11).