Na + -dependent gate dynamics and electrostatic attraction ensure substrate coupling in glutamate transporters

Science Advances, vol. 6

Abstract

:substrate transport stoichiometry over a broad range of neurotransmitter concentrations.

Authors 8

1. Claudia Alleva corresponding

   Forschungszentrum Jülich · Jülich Aachen Research Alliance

   Affiliation as printed

   Institute of Biological Information Processing (IBI-1), Molekular- und Zellphysiologie, and JARA-HPC, Forschungszentrum Jülich, Jülich, Germany

2. Kirill Kovalev corresponding Aachen Institute of Crystallography

   Centre National de la Recherche Scientifique · Moscow Institute of Physics and Technology · Forschungszentrum Jülich · Commissariat à l'Énergie Atomique et aux Énergies Alternatives · Jülich Aachen Research Alliance · Institut de Biologie Structurale · RWTH Aachen University · Université Grenoble Alpes

   Affiliation as printed

   Institut de Biologie Structurale (IBS), Université Grenoble Alpes-CEA-CNRS, 38000 Grenoble, France

   Institute of Biological Information Processing (IBI-1), Molekular- und Zellphysiologie, and JARA-HPC, Forschungszentrum Jülich, Jülich, Germany

   Institute of Biological Information Processing (IBI-7), Structural Biochemistry, Forschungszentrum Jülich, Jülich, Germany

   Institute of Crystallography, RWTH Aachen University, Aachen, Germany

   Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia

3. Roman Astashkin

   Centre National de la Recherche Scientifique · Moscow Institute of Physics and Technology · Commissariat à l'Énergie Atomique et aux Énergies Alternatives · Institut de Biologie Structurale · Université Grenoble Alpes

   Affiliation as printed

   Institut de Biologie Structurale (IBS), Université Grenoble Alpes-CEA-CNRS, 38000 Grenoble, France

   Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia

4. Christian Baeken

   Forschungszentrum Jülich

   Affiliation as printed

   Institute of Biological Information Processing (IBI-7), Structural Biochemistry, Forschungszentrum Jülich, Jülich, Germany

   JuStruct: Jülich Centre for Structural Biology, Forschungszentrum Jülich, Jülich, Germany

5. Taras G. Balandin

   Forschungszentrum Jülich

   Affiliation as printed

   Institute of Biological Information Processing (IBI-7), Structural Biochemistry, Forschungszentrum Jülich, Jülich, Germany

   JuStruct: Jülich Centre for Structural Biology, Forschungszentrum Jülich, Jülich, Germany

6. Valentin Gordeliy

   Centre National de la Recherche Scientifique · Moscow Institute of Physics and Technology · Forschungszentrum Jülich · Commissariat à l'Énergie Atomique et aux Énergies Alternatives · Institut de Biologie Structurale · Université Grenoble Alpes

   Affiliation as printed

   Institut de Biologie Structurale (IBS), Université Grenoble Alpes-CEA-CNRS, 38000 Grenoble, France

   Institute of Biological Information Processing (IBI-7), Structural Biochemistry, Forschungszentrum Jülich, Jülich, Germany

   JuStruct: Jülich Centre for Structural Biology, Forschungszentrum Jülich, Jülich, Germany

   Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia

7. Christoph Fahlke corresponding

   Moscow Institute of Physics and Technology · Forschungszentrum Jülich · Jülich Aachen Research Alliance

   Affiliation as printed

   Institute of Biological Information Processing (IBI-1), Molekular- und Zellphysiologie, and JARA-HPC, Forschungszentrum Jülich, Jülich, Germany

   Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Russia

8. Jan‐Philipp Machtens corresponding Aachen Institute of Clinical Pharmacology

   Forschungszentrum Jülich · Jülich Aachen Research Alliance · RWTH Aachen University

   Affiliation as printed

   Institute of Biological Information Processing (IBI-1), Molekular- und Zellphysiologie, and JARA-HPC, Forschungszentrum Jülich, Jülich, Germany

   Institute of Clinical Pharmacology, RWTH Aachen University, Aachen, Germany