A high-stringency blueprint of the human proteome
Nature Communications, vol. 11, pp. 5301
Abstract
The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP's tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.
Authors 46
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Affiliation as printed
Faculty of Medicine, Health and Human Sciences, Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, 2109, Australia
Macquarie University (Balaclava Road, North Ryde , NSW, 2109, Australia - Australia)
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Monash University · Macquarie University
Affiliation as printed
Faculty of Medicine, Health and Human Sciences, Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, 2109, Australia
Faculty of Medicine, Nursing and Health Sciences, Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, 3800, Australia
Macquarie University (Balaclava Road, North Ryde , NSW, 2109, Australia - Australia)
Monash University [Melbourne] (Victoria 3800, Australia - Australia)
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Affiliation as printed
Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA, 98109, USA
ISB - Institute for Systems Biology [Seattle] (Seattle, WA 98109 - United States)
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University of Geneva · SIB Swiss Institute of Bioinformatics
Affiliation as printed
Faculty of Medicine, SIB-Swiss Institute of Bioinformatics and Department of Microbiology and Molecular Medicine, University of Geneva, CMU, Michel-Servet 1, 1211, Geneva, Switzerland
CMU - Centre médical universitaire de Genève (Rue Michel-Servet 1, 1206 Genève - Switzerland)
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Affiliation as printed
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109-2218, USA
University of Michigan [Ann Arbor] (500 Church Street Ann Arbor, MI 48109-1090 - United States)
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Affiliation as printed
UCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine, University College Dublin, Dublin, Ireland
UCD - University College Dublin [Dublin] (Belfield, Dublin 4 - Ireland)
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Yonsei University · Yonsei Proteome Research Center
Affiliation as printed
Yonsei Proteome Research Center, 50 Yonsei-ro, Sudaemoon-ku, Seoul, 120-749, South Korea
Yonsei University (South Korea)
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University of British Columbia · University of British Columbia, Okanagan Campus
Affiliation as printed
Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada
UBC - University of British Columbia (Vancouver Campus, , 2329 West Mall, Vancouver, BC, V6T 1Z4 / Okanagan Campus, 3333 University Way, Kelowna, BC, V1V 1V7 - Canada)
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Consejo Superior de Investigaciones Científicas · Instituto de Salud Carlos III · Centro Nacional de Biotecnología
Affiliation as printed
Functional Proteomics Laboratory, Centro Nacional de Biotecnología-CSIC, Proteored-ISCIII, 28049, Madrid, Spain
CNB-CSIC - Centro Nacional de Biotecnología [Madrid] (Campus de la Universidad Autónoma de Madrid, 28049 Madrid - Spain)
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Affiliation as printed
Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA
Princeton University (Princeton, NJ 08544 USA - United States)
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Cedars-Sinai Medical Center · Cedars-Sinai Smidt Heart Institute
Affiliation as printed
Cedars Sinai Medical Center, Advanced Clinical Biosystems Research Institute, The Smidt Heart Institute, Los Angeles, CA, 90048, USA
Cedars-Sinai Medical Center (8700 Beverly Blvd, Los Angeles, California 90048 - United States)
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Science for Life Laboratory · KTH Royal Institute of Technology
Affiliation as printed
Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 17121, Solna, Sweden
KTH - KTH Royal Institute of Technology [Stockholm] (SE-100 44, Stockholm, Sweden - Sweden)
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Affiliation as printed
Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75185, Uppsala, Sweden
Uppsala University (Box 256, SE-751 05 Uppsala - Sweden)
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Johns Hopkins University · Johns Hopkins Medicine
Affiliation as printed
Department of Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA
Johns Hopkins University School of Medicine [Baltimore] (733 North Broadway, Suite G49 Baltimore, MD 21205-2196 - United States)
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University of Geneva · SIB Swiss Institute of Bioinformatics
Affiliation as printed
Faculty of Medicine, SIB-Swiss Institute of Bioinformatics and Department of Microbiology and Molecular Medicine, University of Geneva, CMU, Michel-Servet 1, 1211, Geneva, Switzerland
CMU - Centre médical universitaire de Genève (Rue Michel-Servet 1, 1206 Genève - Switzerland)
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Affiliation as printed
UCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine, University College Dublin, Dublin, Ireland
UCD - University College Dublin [Dublin] (Belfield, Dublin 4 - Ireland)
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Affiliation as printed
Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA
Princeton University (Princeton, NJ 08544 USA - United States)
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Affiliation as printed
Biodesign Institute, Arizona State University, Tempe, AZ, USA
ASU - Arizona State University [Tempe] (325 E Apache Blvd, Tempe, AZ 85281, États-Unis - United States)
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National Institutes of Health · National Cancer Institute
Affiliation as printed
Office of Cancer Clinical Proteomics Research, National Cancer Institute, NIH, Bethesda, MD, 20892, USA
NCI-NIH - National Cancer Institute [Bethesda] (BG 9609 MSC 9760, 9609 Medical Center Drive, Bethesda, MD 20892-9760 - United States)
NIH - National Institutes of Health [Bethesda, MD, USA] (9000 Rockville Pike, Bethesda, Maryland 20892, USA - United States)
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Beijing Proteome Research Center · State Key Laboratory of Proteomics
Affiliation as printed
State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China
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University of Bremen · Bruker (Germany)
Affiliation as printed
Bruker Daltonik GmbH, Microbiology and Diagnostics, Fahrenheitstrasse, 428359, Bremen, Germany
Bruker Daltonik GmbH (Germany)
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University of California, Los Angeles
Affiliation as printed
Cardiac Proteomics and Signaling Laboratory, Department of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
David Geffen School of Medicine [Los Angeles] (United States)
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University of Nebraska Medical Center
Affiliation as printed
CardiOmics Program, Center for Heart and Vascular Research, Division of Cardiovascular Medicine and Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA
University of Nebraska Medical Center (42nd and Emile, Omaha, Nebraska 68198, USA - United States)
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Affiliation as printed
Department of Chemical Pathology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
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National Institutes of Health · Indian Institute of Technology Bombay · National Cancer Institute
Affiliation as printed
Cancer Biomarkers Research Branch, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Suite 5E136, Rockville, MD, 20852, USA
Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India
IIT Bombay - Indian Institute of Technology Bombay (Powai, Mumbai - 400076, India - India)
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National Institutes of Health · Indian Institute of Technology Bombay · National Cancer Institute
Affiliation as printed
Cancer Biomarkers Research Branch, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Suite 5E136, Rockville, MD, 20852, USA
Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India
NCI-NIH - National Cancer Institute [Bethesda] (BG 9609 MSC 9760, 9609 Medical Center Drive, Bethesda, MD 20892-9760 - United States)
NIH - National Institutes of Health [Bethesda, MD, USA] (9000 Rockville Pike, Bethesda, Maryland 20892, USA - United States)
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Universidade Federal do Rio de Janeiro · Pontifícia Universidade Católica do Rio de Janeiro
Affiliation as printed
Proteomics Unit and Laboratory of Proteomics, Institute of Chemistry, Federal University of Rio de Janeiro, Av Athos da Silveria Ramos, 149, 21941-909, Rio de Janeiro, RJ, Brazil
PUC-Rio - Pontifícia Universidade Católica do Rio de Janeiro [Brasil] = Pontifical Catholic University of Rio de Janeiro [Brazil] = Université catholique pontificale de Rio de Janeiro [Brésil] (R. Marquês de São Vicente, 225 - Gávea, Rio de Janeiro - RJ, 22451-900, Brésil - Brazil)
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Universidade Federal do Rio de Janeiro
Affiliation as printed
Proteomics Unit and Laboratory of Proteomics, Institute of Chemistry, Federal University of Rio de Janeiro, Av Athos da Silveria Ramos, 149, 21941-909, Rio de Janeiro, RJ, Brazil
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Inserm · Commissariat à l'Énergie Atomique et aux Énergies Alternatives · Laboratoire Biologie à Grande Échelle · Laboratoire Biosciences et bioingénierie pour la Santé
Affiliation as printed
University of Grenoble Alpes, Inserm, CEA, IRIG-BGE, U1038, 38000, Grenoble, France
BGE - UMR S1038 - Laboratoire de Biologie à Grande Échelle (17, Rue des Martyrs 38054 Grenoble cedex 09 - France)
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University of Colorado Anschutz
Affiliation as printed
Consortium for Fibrosis Research and Translation, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA
Departments of Medicine-Cardiology and Biochemistry and Molecular Genetics, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA
University of Colorado Anschutz [Aurora] (https://www.cuanschutz.edu/ University of Colorado Anschutz Medical Campus - United States)
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University of Colorado Anschutz
Affiliation as printed
Division of Cardiology, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA
University of Colorado Anschutz [Aurora] (https://www.cuanschutz.edu/ University of Colorado Anschutz Medical Campus - United States)
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European Bioinformatics Institute
Affiliation as printed
European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
EMBL-EBI - European Bioinformatics Institute [Hinxton] (EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK - United Kingdom)
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Affiliation as printed
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia
UNSW - University of New South Wales [Sydney] (High St Kensington, Sydney, NSW 2052 - Australia)
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Science for Life Laboratory · KTH Royal Institute of Technology
Affiliation as printed
Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 17121, Solna, Sweden
KTH - KTH Royal Institute of Technology [Stockholm] (SE-100 44, Stockholm, Sweden - Sweden)
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Science for Life Laboratory · KTH Royal Institute of Technology
Affiliation as printed
Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 17121, Solna, Sweden
KTH - KTH Royal Institute of Technology [Stockholm] (SE-100 44, Stockholm, Sweden - Sweden)
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University of California San Diego
Affiliation as printed
Department of Computer Science and Engineering, University of California, San Diego, 9500 Gilman Drive, Mail Code 0404, La Jolla, CA, 92093-0404, USA
CSE - UC San Diego - Department of Computer Science and Engineering [Univ California San Diego] (University of California, San Diego, Jacobs School of Engineering, 9500 Gilman Drive, La Jolla, CA 92093-0404 - United States)
UC San Diego - University of California [San Diego] (UCSD, 9500 Gilman Dr., La Jolla, CA 92093 USA - United States)
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Lund University · Skåne University Hospital
Affiliation as printed
Department of Biomedical Engineering, Lund University, Lund, Sweden
Skane University Hospital [Lund] (Getingevägen 4, 222 41 Lund - Sweden)
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The University of Texas at San Antonio Health Science Center
Affiliation as printed
Department of Biochemistry and Structural Biology, University of Texas Health Science Center San Antonio, UT Health, 7703 Floyd Curl Drive, San Antonio, TX, 78229-3900, USA
University of Texas Health Science Center (7703 Floyd Curl Drive San Antonio, Texas 78229-3900 - United States)
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Inserm · École des Hautes Études en Santé Publique · Institut de Recherche en Santé, Environnement et Travail · Université de Rennes
Affiliation as printed
University of Rennes, Inserm, EHESP, IREST, UMR_S 1085, F-35042, Rennes, France
Irset - Institut de recherche en santé, environnement et travail (263 avenue Général Leclerc 35042 Rennes Cedex - France)
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Affiliation as printed
Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA, 98109, USA
ISB - Institute for Systems Biology [Seattle] (Seattle, WA 98109 - United States)
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Affiliation as printed
Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA, 98109, USA
ISB - Institute for Systems Biology [Seattle] (Seattle, WA 98109 - United States)
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Affiliation as printed
Faculty of Medicine, Health and Human Sciences, Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, 2109, Australia
Macquarie University (Balaclava Road, North Ryde , NSW, 2109, Australia - Australia)
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Magnus Palmblad Aachen
Leiden University · Leiden University Medical Center
Affiliation as printed
Leiden University Medical Center, Leiden, 2333, The Netherlands
LUMC - Leiden University Medical Center (Leids Universitair Medisch Centrum, Universiteit Leiden - 1233 ZA, Leiden - Netherlands)
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Stanford Medicine · Stanford University
Affiliation as printed
Department of Genetics, Stanford School of Medicine, Stanford, CA, 94305, USA
Stanford University (450 Serra Mall, Stanford, CA 94305-2004 - United States)
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University of Zurich · Institute for Systems Biology
Affiliation as printed
Faculty of Science, University of Zurich, Zurich, Switzerland
Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA, 98109, USA
ISB - Institute for Systems Biology [Seattle] (Seattle, WA 98109 - United States)
UZH - Universität Zürich [Zürich] = University of Zurich (Rämistrasse 71 CH-8006 Zürich - Switzerland)
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Mark S. Baker corresponding
Stanford Medicine · Stanford University · Macquarie University
Affiliation as printed
Department of Genetics, Stanford School of Medicine, Stanford, CA, 94305, USA. mark.baker@mq.edu.au
Faculty of Medicine, Health and Human Sciences, Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, 2109, Australia. mark.baker@mq.edu.au
Macquarie University (Balaclava Road, North Ryde , NSW, 2109, Australia - Australia)
Stanford School of Medicine [Stanford] (Stanford University, Stanford Medicine, 291 Campus Drive, Stanford, CA 94305 - United States)
Stanford University (450 Serra Mall, Stanford, CA 94305-2004 - United States)
Cited by 211 stored of 210
Cited by patents worldwide 2 (Lens.org)
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