Vitamin K therapy to reduce bleeding

Blood, vol. 136, pp. 780–782

Abstract

In this issue of Blood, Chen et al(1) used a cell-based screening to identify 9 unrelated drugs that may cause bleeding by interfering with the vitamin K (VK) cycle that is required for the VK-dependent g-carboxylation of blood coagulation proteins. Bleeding caused by drugs inhibiting the reduction of VK epoxide, but not VK, can be rescued by VK administration.

Authors 2

1. Mettine H.A. Bos Aachen

   Leiden University Medical Center

   Affiliation as printed

   Leiden University Medical Center

2. Felix J.M. van der Meer Aachen

   Leiden University Medical Center

   Affiliation as printed

   Leiden University Medical Center