Technical validity and usability of a novel smartphone‐connected spirometry device for pediatric patients with asthma and cystic fibrosis
Pediatric Pulmonology, vol. 55, pp. 2463–2470
Abstract
BACKGROUND: Diagnosis and follow-up of respiratory diseases traditionally rely on pulmonary function tests (PFTs), which are currently performed in hospitals and require trained personnel. Smartphone-connected spirometers, like the Air Next spirometer, have been developed to aid in the home monitoring of patients with pulmonary disease. The aim of this study was to investigate the technical validity and usability of the Air Next spirometer in pediatric patients. METHODS: Device variability was tested with a calibrated syringe. About 90 subjects, aged 6 to 16, were included in a prospective cohort study. Fifty-eight subjects performed conventional spirometry and subsequent Air Next spirometry. The bias and the limits of agreement between the measurements were calculated. Furthermore, subjects used the device for 28 days at home and completed a subject-satisfaction questionnaire at the end of the study period. RESULTS: Interdevice variability was 2.8% and intradevice variability was 0.9%. The average difference between the Air Next and conventional spirometry was 40 mL for forced expiratory volume in 1 second (FEV1) and 3 mL for forced vital capacity (FVC). The limits of agreement were -270 mL and +352 mL for FEV1 and -403 mL and +397 mL for FVC. About 45% of FEV1 measurements and 41% of FVC measurements at home were acceptable and reproducible according to American Thoracic Society/European Respiratory Society criteria. Parents scored difficulty, usefulness, and reliability of the device 1.9, 3.5, and 3.8 out of 5, respectively. CONCLUSION: The Air Next device shows validity for the measurement of FEV1 and FVC in a pediatric patient population.
Authors 11
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Matthijs D. Kruizinga corresponding Aachen Centre for Human Drug Research Leiden the Netherlands Department of Pediatrics Leiden University Medical Centre Leiden The Netherlands Centre for Human Drug Research (CHDR) Department of Pediatrics, Leiden University Medical Centre
Leiden University · Leiden University Medical Center · Erasmus MC · Centre for Human Drug Research · Erasmus MC - Sophia Children’s Hospital · Haga Hospital · Juliana Kinderziekenhuis
Affiliation as printed
Centre for Human Drug Research Leiden The Netherlands
Department of Pediatrics Leiden University Medical Centre Leiden The Netherlands
Division of Respiratory Medicine and Allergology, Department of Pediatrics, Erasmus Medical Centre/Sophia Children's Hospital University Hospital Rotterdam Rotterdam The Netherlands
Juliana Children's Hospital HAGA Teaching Hospital The Hague The Netherlands
Centre for Human Drug Research, Leiden, The Netherlands
Department of Pediatrics, Leiden University Medical Centre, Leiden, The Netherlands
Division of Respiratory Medicine and Allergology, Department of Pediatrics, Erasmus Medical Centre/Sophia Children's Hospital, University Hospital Rotterdam, Rotterdam, The Netherlands
Juliana Children's Hospital, HAGA Teaching Hospital, The Hague, The Netherlands
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Esmée Essers Aachen Centre for Human Drug Research Leiden the Netherlands Centre for Human Drug Research (CHDR)
Centre for Human Drug Research · Haga Hospital · Juliana Kinderziekenhuis
Affiliation as printed
Centre for Human Drug Research Leiden The Netherlands
Juliana Children's Hospital HAGA Teaching Hospital The Hague The Netherlands
Centre for Human Drug Research, Leiden, The Netherlands
Juliana Children's Hospital, HAGA Teaching Hospital, The Hague, The Netherlands
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Frederik E. Stuurman Aachen Centre for Human Drug Research Leiden the Netherlands Department of Clinical Pharmacology and Toxicology Leiden University Medical Centre Leiden The Netherlands Centre for Human Drug Research (CHDR) Department of Clinical Pharmacology and Toxicology
Leiden University · Leiden University Medical Center · Centre for Human Drug Research
Affiliation as printed
Centre for Human Drug Research Leiden The Netherlands
Department of Clinical Pharmacology and Toxicology Leiden University Medical Centre Leiden The Netherlands
Centre for Human Drug Research, Leiden, The Netherlands
Department of Clinical Pharmacology and Toxicology, Leiden University Medical Centre, Leiden, The Netherlands
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Ahnjili Zhuparris Aachen Centre for Human Drug Research Leiden the Netherlands Centre for Human Drug Research (CHDR)
Centre for Human Drug Research
Affiliation as printed
Centre for Human Drug Research Leiden The Netherlands
Centre for Human Drug Research, Leiden, The Netherlands
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Haga Hospital · Juliana Kinderziekenhuis
Affiliation as printed
Juliana Children's Hospital HAGA Teaching Hospital The Hague The Netherlands
Juliana Children's Hospital, HAGA Teaching Hospital, The Hague, The Netherlands
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Erasmus MC · Erasmus MC - Sophia Children’s Hospital
Affiliation as printed
Division of Respiratory Medicine and Allergology, Department of Pediatrics, Erasmus Medical Centre/Sophia Children's Hospital University Hospital Rotterdam Rotterdam The Netherlands
Division of Respiratory Medicine and Allergology, Department of Pediatrics, Erasmus Medical Centre/Sophia Children's Hospital, University Hospital Rotterdam, Rotterdam, The Netherlands
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Haga Hospital · Juliana Kinderziekenhuis
Affiliation as printed
Juliana Children's Hospital HAGA Teaching Hospital The Hague The Netherlands
Juliana Children's Hospital, HAGA Teaching Hospital, The Hague, The Netherlands
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Haga Hospital · Juliana Kinderziekenhuis
Affiliation as printed
Juliana Children's Hospital HAGA Teaching Hospital The Hague The Netherlands
Juliana Children's Hospital, HAGA Teaching Hospital, The Hague, The Netherlands
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Haga Hospital · Juliana Kinderziekenhuis
Affiliation as printed
Juliana Children's Hospital HAGA Teaching Hospital The Hague The Netherlands
Juliana Children's Hospital, HAGA Teaching Hospital, The Hague, The Netherlands
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Adam F. Cohen Aachen Centre for Human Drug Research Leiden the Netherlands Department of Internal Medicine Leiden University Medical Centre Leiden The Netherlands Centre for Human Drug Research (CHDR) Department of Internal Medicine
Leiden University · Leiden University Medical Center · Centre for Human Drug Research
Affiliation as printed
Centre for Human Drug Research Leiden The Netherlands
Department of Internal Medicine Leiden University Medical Centre Leiden The Netherlands
Centre for Human Drug Research, Leiden, The Netherlands
Department of Internal Medicine, Leiden University Medical Centre, Leiden, The Netherlands
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Haga Hospital · Juliana Kinderziekenhuis
Affiliation as printed
Juliana Children's Hospital HAGA Teaching Hospital The Hague The Netherlands
Juliana Children's Hospital, HAGA Teaching Hospital, The Hague, The Netherlands
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