Four‐Dimensional Deoxyribonucleic Acid–Gold Nanoparticle Assemblies

Angewandte Chemie International Edition, vol. 59, pp. 17250–17255

Abstract

Organization of gold nanoobjects by oligonucleotides has resulted in many three-dimensional colloidal assemblies with diverse size, shape, and complexity; nonetheless, autonomous and temporal control during formation remains challenging. In contrast, living systems temporally and spatially self-regulate formation of functional structures by internally orchestrating assembly and disassembly kinetics of dissipative biomacromolecular networks. We present a novel approach for fabricating four-dimensional gold nanostructures by adding an additional dimension: time. The dissipative character of our system is achieved using exonuclease III digestion of deoxyribonucleic acid (DNA) fuel as an energy-dissipating pathway. Temporal control over amorphous clusters composed of spherical gold nanoparticles (AuNPs) and well-defined core-satellite structures from gold nanorods (AuNRs) and AuNPs is demonstrated. Furthermore, the high specificity of DNA hybridization allowed us to demonstrate selective activation of the evolution of multiple architectures of higher complexity in a single mixture containing small and larger spherical AuNPs and AuNRs.

Authors 8

1. Ming Luo Aachen DWI - Leibniz Institute for Interactive Materials

   University of Electronic Science and Technology of China · DWI – Leibniz Institute for Interactive Materials

   Affiliation as printed

   DWI-Leibniz Institute for Interactive Materials Forckenbeckstr. 50 52056 Aachen Germany

   Institute of Fundamental and Frontier Sciences (IFFS) University of Electronic Science and Technology of China (UESTC) 610054 Chengdu China

   DWI-Leibniz Institute for Interactive Materials, Forckenbeckstr. 50, 52056 Aachen, Germany

   Institute of Fundamental and Frontier Sciences (IFFS), University of Electronic Science and Technology of China (UESTC), 610054 Chengdu, China

2. Mingjun Xuan Aachen Institute of Technical and Macromolecular Chemistry DWI - Leibniz Institute for Interactive Materials

   DWI – Leibniz Institute for Interactive Materials · RWTH Aachen University

   Affiliation as printed

   DWI-Leibniz Institute for Interactive Materials Forckenbeckstr. 50 52056 Aachen Germany

   Institute of Technical and Macromolecular Chemistry RWTH Aachen University Worringerweg 2 52074 Aachen Germany

   DWI-Leibniz Institute for Interactive Materials, Forckenbeckstr. 50, 52056 Aachen, Germany

   Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Worringerweg 2, 52074 Aachen, Germany

3. Shuaidong Huo Aachen DWI - Leibniz Institute for Interactive Materials

   DWI – Leibniz Institute for Interactive Materials

   Affiliation as printed

   DWI-Leibniz Institute for Interactive Materials Forckenbeckstr. 50 52056 Aachen Germany

   DWI-Leibniz Institute for Interactive Materials, Forckenbeckstr. 50, 52056 Aachen, Germany

4. Jilin Fan Aachen Institute of Technical and Macromolecular Chemistry DWI - Leibniz Institute for Interactive Materials

   DWI – Leibniz Institute for Interactive Materials · RWTH Aachen University

   Affiliation as printed

   DWI-Leibniz Institute for Interactive Materials Forckenbeckstr. 50 52056 Aachen Germany

   Institute of Technical and Macromolecular Chemistry RWTH Aachen University Worringerweg 2 52074 Aachen Germany

   DWI-Leibniz Institute for Interactive Materials, Forckenbeckstr. 50, 52056 Aachen, Germany

   Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Worringerweg 2, 52074 Aachen, Germany

5. Gurudas Chakraborty Aachen Institute of Technical and Macromolecular Chemistry DWI - Leibniz Institute for Interactive Materials

   DWI – Leibniz Institute for Interactive Materials · RWTH Aachen University

   Affiliation as printed

   DWI-Leibniz Institute for Interactive Materials Forckenbeckstr. 50 52056 Aachen Germany

   Institute of Technical and Macromolecular Chemistry RWTH Aachen University Worringerweg 2 52074 Aachen Germany

   DWI-Leibniz Institute for Interactive Materials, Forckenbeckstr. 50, 52056 Aachen, Germany

   Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Worringerweg 2, 52074 Aachen, Germany

6. Yixi Wang

   University of Electronic Science and Technology of China

   Affiliation as printed

   Institute of Fundamental and Frontier Sciences (IFFS) University of Electronic Science and Technology of China (UESTC) 610054 Chengdu China

   Institute of Fundamental and Frontier Sciences (IFFS), University of Electronic Science and Technology of China (UESTC), 610054 Chengdu, China

7. Hui Zhao corresponding

   University of Electronic Science and Technology of China · Sichuan University

   Affiliation as printed

   Institute of Fundamental and Frontier Sciences (IFFS) University of Electronic Science and Technology of China (UESTC) 610054 Chengdu China

   School of Chemical Engineering Sichuan University 610055 Chengdu China

   Institute of Fundamental and Frontier Sciences (IFFS), University of Electronic Science and Technology of China (UESTC), 610054 Chengdu, China

   School of Chemical Engineering, Sichuan University, 610055 Chengdu, China

8. Lifei Zheng corresponding Aachen Institute of Technical and Macromolecular Chemistry DWI - Leibniz Institute for Interactive Materials

   DWI – Leibniz Institute for Interactive Materials · RWTH Aachen University

   Affiliation as printed

   DWI-Leibniz Institute for Interactive Materials Forckenbeckstr. 50 52056 Aachen Germany

   Institute of Technical and Macromolecular Chemistry RWTH Aachen University Worringerweg 2 52074 Aachen Germany

   DWI-Leibniz Institute for Interactive Materials, Forckenbeckstr. 50, 52056 Aachen, Germany

   Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Worringerweg 2, 52074 Aachen, Germany