The druggable genome and support for target identification and validation in drug development

• Cluster Headache Genomewide Association Study and Meta‐Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor

  2023 Annals of Neurology article Medicine Migraine and Headache Studies Open access

  59

  citations
• Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

  2022 Nature Communications article Medicine Cardiac electrophysiology and arrhythmias Open access

  53

  citations
• Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome

  2021 Nature Communications article Medicine Parkinson's Disease Mechanisms and Treatments Open access cited by 1 patent

  209

  citations
• Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization

  2021 medRxiv preprint Medicine Cardiac electrophysiology and arrhythmias Open access

  1

  citations
• Pan-cancer in silico analysis of somatic mutations in G-protein coupled receptors: The effect of evolutionary conservation and natural variance

  2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Cancer Genomics and Diagnostics Open access

  3

  citations
• Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

  2021 Cell article Medicine Osteoarthritis Treatment and Mechanisms Open access

  437

  citations
• In silico drug discovery for a complex immunotherapeutic target - human c-Rel protein

  2021 Biophysical Chemistry article Computer Science Computational Drug Discovery Methods

  3

  citations
• Systematic Prioritization of Candidate Genes in Disease Loci Identifies TRAFD1 as a Master Regulator of IFNγ Signaling in Celiac Disease

  2021 Frontiers in Genetics article Medicine Celiac Disease Research and Management Open access cited by 1 patent

  48

  citations
• Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

  2020 Nature Genetics review Biochemistry, Genetics and Molecular Biology Genetic Associations and Epidemiology Open access cited by 2 patents

  248

  citations
• Systematic prioritization of candidate genes in disease loci identifies TRAFD1 as a master regulator of IFNγ signalling in celiac disease

  2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Celiac Disease Research and Management Open access

  6

  citations

10 results