Goodbye to brute force in antibiotic discovery?

• Inducible CRISPRi enables efficient and high-fidelity genome editing in Streptomyces

  2026 Nucleic Acids Research article Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access

  0

  citations
• COMMBAT: a web platform for exploring expression control of biosynthetic gene clusters

  2026 Nucleic Acids Research article Medicine Microbial Natural Products and Biosynthesis Open access

  2

  citations
• Diversification of Tridecaptin Chemical Space via a Chimeric Biosynthetic Pathway in Paenibacillus

  2026 Journal of Natural Products article Medicine Microbial Natural Products and Biosynthesis Open access

  1

  citations
• Discovery and Derivatization of Tridecaptin Antibiotics with Altered Host Specificity and Enhanced Bioactivity

  2024 ACS Chemical Biology article Medicine Microbial Natural Products and Biosynthesis Open access

  9

  citations
• Discovery of actinomycin L, a new member of the actinomycin family of antibiotics

  2022 Scientific Reports article Medicine Microbial Natural Products and Biosynthesis Open access

  40

  citations
• The ubiquitous catechol moiety elicits siderophore and angucycline production in Streptomyces

  2022 Communications Chemistry article Medicine Microbial Natural Products and Biosynthesis Open access

  31

  citations
• New from old: discovery of the novel antibiotic actinomycin L in Streptomyces sp. MBT27

  2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Microbial Natural Products and Biosynthesis Open access

  1

  citations
• Omics-based strategies to discover novel classes of RiPP natural products

  2020 Current Opinion in Biotechnology review Medicine Microbial Natural Products and Biosynthesis Open access cited by 1 patent

  53

  citations
• Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides

  2020 PLoS Biology article Medicine Microbial Natural Products and Biosynthesis Open access cited by 2 patents

  131

  citations
• Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway

  2020 ACS Chemical Biology article Medicine Microbial Natural Products and Biosynthesis Open access

  14

  citations
• Integration of machine learning and pan-genomics expands the biosynthetic landscape of RiPP natural products

  2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Microbial Natural Products and Biosynthesis Open access

  5

  citations

11 results