The integrated stress response

• Systematic comparison of temporal hepatotoxicant-induced gene network responses across 3 liver test systems

  2026 Toxicological Sciences article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access

  0

  citations
• RNF25 confers mRNA damage tolerance by curbing activation of the integrated stress response

  2026 Molecular Cell article Biochemistry, Genetics and Molecular Biology RNA and protein synthesis mechanisms Open access

  8

  citations
• A de novo dominant-negative PSMB8 mutation causes severe CANDLE/PRAAS due to arrested proteasome biogenesis

  2025 Annals of the Rheumatic Diseases article Biochemistry, Genetics and Molecular Biology Inflammasome and immune disorders Open access

  6

  citations
• Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial

  2025 Nature Communications article Medicine Amyotrophic Lateral Sclerosis Research Open access

  20

  citations
• Mathematical modelling reveals compound-specific stress pathway activity

  2025 Toxicology article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access

  4

  citations
• Direct neuronal reprogramming of NDUFS4 patient cells identifies the unfolded protein response as a novel general reprogramming hurdle

  2024 Neuron article Biochemistry, Genetics and Molecular Biology Pluripotent Stem Cells Research Open access

  19

  citations
• The Anti-Inflammatory Action of Pulsed Radiofrequency—A Hypothesis and Potential Applications

  2023 Medical Sciences article Biochemistry, Genetics and Molecular Biology Electromagnetic Fields and Biological Effects Open access

  9

  citations
• Plant HEM1 specifies a condensation domain to control immune gene translation

  2023 Nature Plants article Agricultural and Biological Sciences Plant-Microbe Interactions and Immunity

  62

  citations
• Mapping the cardiac vascular niche in heart failure

  2022 Nature Communications article Medicine Cardiac Fibrosis and Remodeling Open access

  103

  citations
• The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment

  2021 Archives of Toxicology article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access

  43

  citations
• The human hepatocyte TXG-MAPr: WGCNA transcriptomic modules to support mechanism-based risk assessment

  2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access

  1

  citations
• Hsp90-mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling

  2021 EMBO Reports article Biochemistry, Genetics and Molecular Biology Heat shock proteins research Open access

  84

  citations
• EIF2AK2 Missense Variants Associated with Early Onset Generalized Dystonia

  2020 Annals of Neurology article Medicine Neurological disorders and treatments Open access

  68

  citations
• Deletion of Perilipin 5 Protects against Hepatic Injury in Nonalcoholic Fatty Liver Disease via Missing Inflammasome Activation

  2020 Cells article Medicine Liver Disease Diagnosis and Treatment Open access

  29

  citations

14 results