Integration, scaling, space-group assignment and post-refinement

• The novel GlcNAc 6-phosphate dehydratase NagS governs a metabolic checkpoint that controls nutrient signaling in Streptomyces

  2025 PLoS Biology article Biochemistry, Genetics and Molecular Biology Bacterial Genetics and Biotechnology Open access

  0

  citations
• Optimization of 2,3-dihydrophthalazine-1,4-dione PARP inhibitor scaffold for nanomolar potency and specificity towards human PARP10

  2025 European Journal of Medicinal Chemistry article Medicine PARP inhibition in cancer therapy Open access

  1

  citations
• A new pathway in central metabolism mediates nutrient control of development and antibiotic production by Streptomyces

  2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Microbial Natural Products and Biosynthesis Open access

  2

  citations
• Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization

  2024 Journal of Medicinal Chemistry article Medicine Cholinesterase and Neurodegenerative Diseases Open access

  8

  citations
• Functional and structural asymmetry suggest a unifying principle for catalysis in membrane-bound pyrophosphatases

  2024 EMBO Reports article Biochemistry, Genetics and Molecular Biology ATP Synthase and ATPases Research Open access

  11

  citations
• Invasive Staphylococcus epidermidis uses a unique processive wall teichoic acid glycosyltransferase to evade immune recognition

  2023 Science Advances article Medicine Antimicrobial Resistance in Staphylococcus Open access

  12

  citations
• Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors

  2023 Science article Computer Science Computational Drug Discovery Methods Open access

  191

  citations
• Engineering a new-to-nature cascade for phosphate-dependent formate to formaldehyde conversion in vitro and in vivo

  2023 Nature Communications article Biochemistry, Genetics and Molecular Biology Microbial Metabolic Engineering and Bioproduction Open access cited by 2 patents

  50

  citations
• [1,2,4]Triazolo[3,4- b ]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes

  2023 Journal of Medicinal Chemistry article Medicine PARP inhibition in cancer therapy Open access cited by 1 patent

  30

  citations
• Human T cells recognize HLA-DP–bound peptides in two orientations

  2022 Proceedings of the National Academy of Sciences article Biochemistry, Genetics and Molecular Biology vaccines and immunoinformatics approaches Open access

  26

  citations
• Crystal structure of semi-synthetic obelin-v after calcium induced bioluminescence implies coelenteramine as the main reaction product

  2022 Scientific Reports article Biochemistry, Genetics and Molecular Biology bioluminescence and chemiluminescence research Open access

  4

  citations
• Functional and structural asymmetry suggest a unifying principle for catalysis in integral membrane-bound pyrophosphatases

  2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology ATP Synthase and ATPases Research Open access

  2

  citations
• [1,2,4]Triazolo[3,4- b ]benzothiazole scaffold as versatile nicotinamide mimic allowing nanomolar inhibition of different PARP enzymes

  2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine PARP inhibition in cancer therapy Open access

  0

  citations
• Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15

  2022 European Journal of Medicinal Chemistry article Medicine PARP inhibition in cancer therapy Open access

  11

  citations
• Rational design of a hydrolysis-resistant mycobacterial phosphoglycolipid antigen presented by CD1c to T cells

  2021 Journal of Biological Chemistry article Biochemistry, Genetics and Molecular Biology vaccines and immunoinformatics approaches Open access

  12

  citations
• Evaluation of 3‐ and 4‐Phenoxybenzamides as Selective Inhibitors of the Mono‐ADP‐Ribosyltransferase PARP10

  2021 ChemistryOpen article Medicine PARP inhibition in cancer therapy Open access

  14

  citations
• Crystal Structure and Subsequent Ligand Design of a Nonriboside Partial Agonist Bound to the Adenosine A2A Receptor

  2021 Journal of Medicinal Chemistry article Biochemistry, Genetics and Molecular Biology Adenosine and Purinergic Signaling Open access cited by 1 patent

  41

  citations
• K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap

  2020 Cell chemical biology article Biochemistry, Genetics and Molecular Biology Ubiquitin and proteasome pathways Open access

  27

  citations
• Coordination Compounds Featuring Non-Toxic Chiral 1,4-Dicarboxylic Acids and Copper(II)

  2020 Crystals article Chemistry Crystal structures of chemical compounds Open access

  5

  citations

19 results