The PDB_REDO server for macromolecular structure model optimization

• Phosphate ions modulate enzyme activity and epistatic effects in two clavulanic acid‐resistant β‐lactamase mutants

  2025 Protein Science article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access

  3

  citations
• Directed evolution of a beta‐lactamase samples a wide variety of conformational states

  2025 Protein Science article Biochemistry, Genetics and Molecular Biology Protein Structure and Dynamics Open access

  0

  citations
• A glycine at position 105 leads to clavulanic acid and avibactam resistance in class A β-lactamases

  2025 Journal of Biological Chemistry article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access

  2

  citations
• Bimodal substrate binding in the active site of the glycosidase B c X

  2024 FEBS Journal article Materials Science Enzyme Structure and Function Open access

  2

  citations
• A low-barrier proton shared between two aspartates acts as a conformational switch that changes the substrate specificity of the β-lactamase BlaC

  2024 International Journal of Biological Macromolecules article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access

  7

  citations
• The small CRL4CSA ubiquitin ligase component DDA1 regulates transcription-coupled repair dynamics

  2024 Nature Communications article Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access

  19

  citations
• Conserved proline residues prevent dimerization and aggregation in the β‐lactamase BlaC

  2024 Protein Science article Materials Science Enzyme Structure and Function Open access

  5

  citations
• DDA1, a novel factor in transcription-coupled repair, modulates CRL4CSA dynamics at DNA damage-stalled RNA polymerase II

  2023 Research Square preprint Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access

  3

  citations
• Enhanced activity against a third-generation cephalosporin by destabilization of the active site of a class A beta-lactamase

  2023 International Journal of Biological Macromolecules article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access

  13

  citations
• Asp179 in the class A β‐lactamase from Mycobacterium tuberculosis is a conserved yet not essential residue due to epistasis

  2023 FEBS Journal article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access

  9

  citations
• The CCP 4 suite: integrative software for macromolecular crystallography

  2023 Acta Crystallographica Section D Structural Biology article Materials Science Enzyme Structure and Function Open access cited by 3 patents

  919

  citations
• Unexpected moves: a conformational change in MutSα enables high-affinity DNA mismatch binding

  2023 Nucleic Acids Research article Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access

  11

  citations
• Chemical Toolkit for PARK7: Potent, Selective, and High-Throughput

  2022 Journal of Medicinal Chemistry article Medicine Parkinson's Disease Mechanisms and Treatments Open access cited by 1 patent

  16

  citations
• CCP 4 Cloud for structure determination and project management in macromolecular crystallography

  2022 Acta Crystallographica Section D Structural Biology article Materials Science Enzyme Structure and Function Open access cited by 2 patents

  89

  citations
• The G132S Mutation Enhances the Resistance of Mycobacterium tuberculosis β-Lactamase against Sulbactam

  2021 Biochemistry article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access

  21

  citations
• Two β-Lactamase Variants with Reduced Clavulanic Acid Inhibition Display Different Millisecond Dynamics

  2021 Antimicrobial Agents and Chemotherapy article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access

  14

  citations
• Conserved residues Glu37 and Trp229 play an essential role in protein folding of β‐lactamase

  2021 FEBS Journal article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access

  9

  citations
• K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap

  2020 Cell chemical biology article Biochemistry, Genetics and Molecular Biology Ubiquitin and proteasome pathways Open access

  27

  citations

18 results