Pharmacogenomics Knowledge for Personalized Medicine

• Survival of patients with colorectal or pancreatic cancer who received UGT1A1 genotype-guided dosing of irinotecan in the Netherlands (2017–2024): a retrospective, multicentre cohort study

  2026 The Lancet Regional Health - Europe article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access

  1

  citations
• The quantitative impact of metabolism‐inhibiting drugs on the occurrence of adverse drug reactions—A backward selection approach

  2026 British Journal of Clinical Pharmacology article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access

  0

  citations
• Clinical Applications of Pharmacogenetics in Improving Drug Safety

  2024 Springer eBooks book-chapter Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism

  0

  citations
• Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorders

  2022 Translational Psychiatry article Medicine Schizophrenia research and treatment Open access

  33

  citations
• Contribution of common and rare genetic variants in CEP72 on vincristine‐induced peripheral neuropathy in brain tumour patients

  2022 British Journal of Clinical Pharmacology article Medicine Cancer Treatment and Pharmacology Open access

  9

  citations
• Evaluation of the EMPAR study population on the basis of metabolic phenotypes of selected pharmacogenes

  2022 The Pharmacogenomics Journal article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access

  1

  citations
• UGT1A1 genotype-guided dosing of irinotecan: A prospective safety and cost analysis in poor metaboliser patients

  2022 European Journal of Cancer article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access

  57

  citations
• Classification of Companion Diagnostics: A New Framework for Biomarker-Driven Patient Selection

  2021 Therapeutic Innovation & Regulatory Science article Mathematics Statistical Methods in Clinical Trials Open access

  13

  citations
• Substrate Specificity of CYP2D6 Genetic Variants

  2021 Pharmacogenomics article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access

  24

  citations
• Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene–drug interaction between CYP2D6 and opioids (codeine, tramadol and oxycodone)

  2021 European Journal of Human Genetics article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access

  59

  citations
• Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorder

  2021 medRxiv preprint Medicine Schizophrenia research and treatment Open access

  2

  citations
• Vitamin K antagonist anticoagulant usage is associated with increased incidence and progression of osteoarthritis

  2021 Annals of the Rheumatic Diseases article Nursing Vitamin K Research Studies Open access

  41

  citations
• Personalized Therapy for Mycophenolate: Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology

  2021 Therapeutic Drug Monitoring article Medicine Renal Transplantation Outcomes and Treatments Open access

  208

  citations
• Systematic Prioritization of Candidate Genes in Disease Loci Identifies TRAFD1 as a Master Regulator of IFNγ Signaling in Celiac Disease

  2021 Frontiers in Genetics article Medicine Celiac Disease Research and Management Open access cited by 1 patent

  48

  citations
• Pre-therapeutic UGT1A1 genotyping to reduce the risk of irinotecan-induced severe toxicity: Ready for prime time

  2020 European Journal of Cancer article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access cited by 1 patent

  53

  citations
• Analysis of Drug Metabolizing Gene Panel in Osteosarcoma Patients Identifies Association Between Variants in SULT1E1, CYP2B6 and CYP4F8 and Methotrexate Levels and Toxicities

  2020 Frontiers in Pharmacology article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access

  14

  citations
• Population Pharmacokinetic and Pharmacogenetic Analysis of Mitotane in Patients with Adrenocortical Carcinoma: Towards Individualized Dosing

  2020 Clinical Pharmacokinetics article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access

  13

  citations
• Adverse Drug Reactions in the Emergency Department: Is There a Role for Pharmacogenomic Profiles at Risk?—Results from the ADRED Study

  2020 Journal of Clinical Medicine article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access

  19

  citations
• Systematic prioritization of candidate genes in disease loci identifies TRAFD1 as a master regulator of IFNγ signalling in celiac disease

  2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Celiac Disease Research and Management Open access

  6

  citations
• Genetic Polymorphisms Affecting Cardiac Biomarker Concentrations in Children with Cancer: an Analysis from the “European Paediatric Oncology Off-patents Medicines Consortium” (EPOC) Trial

  2020 European Journal of Drug Metabolism and Pharmacokinetics article Medicine Chemotherapy-induced cardiotoxicity and mitigation Open access

  14

  citations

20 results