Pharmacologic target-mediated drug disposition

• Local depletion of large molecule drugs due to target binding in tissue interstitial space

  2024 CPT Pharmacometrics & Systems Pharmacology article Computer Science Computational Drug Discovery Methods Open access

  8

  citations
• The quest for balance between capturing data and model complexity: A quantitative clinical pharmacology approach applied to monoclonal antibodies

  2023 CPT Pharmacometrics & Systems Pharmacology article Medicine Monoclonal and Polyclonal Antibodies Research Open access

  7

  citations
• Impact of enzyme turnover on the dynamics of the Michaelis–Menten model

  2022 Mathematical Biosciences article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access

  11

  citations
• An Extended Model Including Target Turnover, Ligand–Target Complex Kinetics, and Binding Properties to Describe Drug–Receptor Interactions

  2021 Methods in molecular biology book-chapter Computer Science Computational Drug Discovery Methods

  3

  citations
• Comparisons of basic target-mediated drug disposition (TMDD) and ligand facilitated target removal (LFTR)

  2021 European Journal of Pharmaceutical Sciences article Mathematics Statistical Methods in Clinical Trials Open access

  6

  citations
• A 3D brain unit model to further improve prediction of local drug distribution within the brain

  2020 PLoS ONE article Neuroscience Barrier Structure and Function Studies Open access

  11

  citations
• Population pharmacokinetics and pharmacodynamics of a novel vascular adhesion protein-1 inhibitor using a multiple-target mediated drug disposition model

  2020 Journal of Pharmacokinetics and Pharmacodynamics article Medicine Pharmaceutical studies and practices Open access

  1

  citations

7 results