Drug–target residence time and its implications for lead optimization

• Design and Development of New Dual Target Agents, Cannabinoid Subtype 2 Receptor (CB2R) Agonists, and Fatty Acid Amide Hydrolase (FAAH) Inhibitors against Neurodegeneration

  2026 Journal of Medicinal Chemistry article Medicine Cannabis and Cannabinoid Research

  0

  citations
• Ehrlich occupancy time: beyond $$k_\textrm{off}$$ to a complete residence time framework

  2026 Journal of Pharmacokinetics and Pharmacodynamics article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling

  0

  citations
• Ehrlich occupancy time: Beyond k off to a complete residence time framework

  2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access

  0

  citations
• Kinetic multiplex assay to assess biased signaling of clinical GPCR agonists

  2025 Pharmacological Research article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access

  6

  citations
• Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB 1 R)

  2024 Journal of Medicinal Chemistry article Medicine Cannabis and Cannabinoid Research Open access cited by 2 patents

  9

  citations
• Drug Design in the Exascale Era: A Perspective from Massively Parallel QM/MM Simulations

  2023 Journal of Chemical Information and Modeling article Physics and Astronomy Advanced Chemical Physics Studies Open access

  58

  citations
• Structural basis of selective cannabinoid CB2 receptor activation

  2023 Nature Communications article Medicine Cannabis and Cannabinoid Research Open access

  78

  citations
• A Comprehensive Guide for Assessing Covalent Inhibition in Enzymatic Assays Illustrated with Kinetic Simulations

  2022 Current Protocols article Biochemistry, Genetics and Molecular Biology Enzyme function and inhibition Open access

  109

  citations
• International Union of Basic and Clinical Pharmacology. CXII: Adenosine Receptors: A Further Update

  2022 Pharmacological Reviews article Biochemistry, Genetics and Molecular Biology Adenosine and Purinergic Signaling Open access cited by 5 patents

  155

  citations
• Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells

  2020 Journal of the American Chemical Society article Medicine Cannabis and Cannabinoid Research Open access cited by 3 patents

  51

  citations
• Revisit ligand-receptor interaction at the human vasopressin V2 receptor: A kinetic perspective

  2020 European Journal of Pharmacology article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling

  18

  citations
• Perspective: Implications of Ligand–Receptor Binding Kinetics for Therapeutic Targeting of G Protein-Coupled Receptors

  2020 ACS Pharmacology & Translational Science article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access

  67

  citations

12 results