A
Menu
First published August 18, 2022 Application Aachen patent A – Human necessities

IMMUNOGENIC POLYPEPTIDES AND PHARMACEUTICAL COMPOSITIONS

Espacenet Family 76159871

Abstract

The invention relates to immunogenic polypeptides, particularly polypeptides comprising an amino acid sequence selected from the group set out in SEQ ID NOs: 1 to 26 of Table 1, or variant of such sequences that incorporate an amino acid sequence that differs from one of SEQ ID NOs: 1 to 26 by alteration of up to 2 amino acid residues within the coronavirus-derived portion of the sequence set out in Table 1. The polypeptides may be linear, or branched, and may be subject to modification, such as by addition of palmitic acid, at the N or C terminal. There are also provided nucleic acid sequences encoding the polypeptides, pharmaceutical compositions comprising such polypeptides or nucleic acid sequences, and cells expressing the polypeptides or comprising the nucleic acid sequences. These agents are useful for the prevention or treatment of coronavirus-based infections, such as COVID-19 caused by SARS-CoV-2. Accordingly, the invention also provided medical uses and methods of treatment directed to the prevention or treatment of such infections. Certain formulations using the polypeptides in combination with adjuvants and/or carriers are demonstrated to offer particular advantages.

Inventors 4

  1. Luis Javier Cruz Aachen author as filed: Cruz, Luis J.
  2. Candido G. Da Silva Aachen author as filed: da Silva, Cândido G.
  3. Chih Kit Chung Aachen author as filed: Chung, Chih Kit
  4. Christina Eich Aachen author as filed: Eich, Christina

Inventors are linked to an Aachen author when surname and first name match exactly one author.

Applicants

  • ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC) GBS Leiden

Cited papers 2 in the database

Non-patent literature as cited (9)
  • - AHMED SYED FARAZ ET AL: "Preliminary Identification of Potential Vaccine Targets for the COVID-19 Coronavirus (SARS-CoV-2) Based on SARS-CoV Immunological Studies", VIRUSES, vol. 12, no. 3, 25 February 2020 (2020-02-25), CH, pages 1 - 15, XP055823903, ISSN: 1999-4915, DOI: 10.3390/v12030254
  • - TOHIDINIA MARYAM ET AL: "Identification B and T-Cell epitopes and functional exposed amino acids of S protein as a potential vaccine candidate against SARS-CoV-2/COVID-19", MICROBIAL PATHOGENESIS, ACADEMIC PRESS LIMITED, NEW YORK, NY, US, vol. 148, 21 August 2020 (2020-08-21), XP086352621, ISSN: 0882-4010, [retrieved on 20200821], DOI: 10.1016/J.MICPATH.2020.104459
  • - KWARTENG ALEXANDER ET AL: "Targeting the SARS-CoV2 nucleocapsid protein for potential therapeutics using immuno-informatics and structure-based drug discovery techniques", BIOMEDICINE & PHARMACOTHERAPY, ELSEVIER, FR, vol. 132, 20 October 2020 (2020-10-20), XP086354746, ISSN: 0753-3322, [retrieved on 20201020], DOI: 10.1016/J.BIOPHA.2020.110914
  • - KUMAR VIPUL ET AL: "Reverse vaccinology approach towards the in-silico multiepitope vaccine development against SARS-CoV-2", vol. 10, 23 January 2021 (2021-01-23), pages 44, XP055857117, Retrieved from the Internet <URL:https://f1000researchdata.s3.amazonaws.com/manuscripts/39433/ea715dd5-43d8-48e7-8659-53f61986d324_36371_-_manoj_jena.pdf?doi=10.12688/f1000research.36371.1&numberOfBrowsableCollections=29&numberOfBrowsableInstitutionalCollections=4&numberOfBrowsableGateways=29> DOI: 10.12688/f1000research.36371.1
  • - SIROHI PREETI RANA ET AL: "Multiple epitope-based vaccine prediction against SARS-CoV-2 spike glycoprotein", JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 27 November 2020 (2020-11-27), US, pages 1 - 12, XP055857110, ISSN: 0739-1102, DOI: 10.1080/07391102.2020.1846626
  • - LIN LI ET AL: "Epitope-based peptide vaccines predicted against novel coronavirus disease caused by SARS-CoV-2", VIRUS RESEARCH, AMSTERDAM, NL, vol. 288, 1 July 2020 (2020-07-01), XP086262746, ISSN: 0168-1702, [retrieved on 20200701], DOI: 10.1016/J.VIRUSRES.2020.198082
  • - SMITH CHRISTOF C. ET AL: "Landscape and Selection of Vaccine Epitopes in SARS-CoV-2", BIORXIV, 4 June 2020 (2020-06-04), pages 1 - 27, XP055845161, Retrieved from the Internet <URL:https://www.biorxiv.org/content/10.1101/2020.06.04.135004v1.full.pdf> [retrieved on 20210928], DOI: 10.1101/2020.06.04.135004
  • - KIYOTANI KAZUMA ET AL: "Bioinformatic prediction of potential T cell epitopes for SARS-Cov-2", JOURNAL OF HUMAN GENETICS, SPRINGER SINGAPORE, SINGAPORE, vol. 65, no. 7, 6 May 2020 (2020-05-06), pages 569 - 575, XP037153205, ISSN: 1434-5161, [retrieved on 20200506], DOI: 10.1038/S10038-020-0771-5
  • - FLORINDO HELENA F ET AL: "Immune-mediated approaches against COVID-19", NATURE NANOTECHNOLOGY, NATURE PUB. GROUP, INC, LONDON, vol. 15, no. 8, 13 July 2020 (2020-07-13), pages 630 - 645, XP037212566, ISSN: 1748-3387, [retrieved on 20200713], DOI: 10.1038/S41565-020-0732-3

Cited patents 2

CN111892648A WO2020257317A1