Predictive Pharmacology group ▲ Sign in to save

• ▲ Elizabeth C. M. de Lange

  Leiden University Neuroscience
  8.12k

  citations

  48

  h-index

  72

  Aachen papers
• ▲ Robin J. G. Hartman

  AstraZeneca (United Kingdom) Immunology and Microbiology
  1.5k

  citations

  21

  h-index

  1

  Aachen papers
• ▲ Mengxu Zhang

  Leiden University Medicine
  40

  citations

  3

  h-index

  5

  Aachen papers

3 results

• Blood-brain barrier perturbations by uremic toxins: Key contributors in chronic kidney disease-induced neurological disorders?

  2023 European Journal of Pharmaceutical Sciences article Neuroscience Barrier Structure and Function Studies Open access

  42

  citations
• Understanding the Blood‐Brain Barrier and Beyond: Challenges and Opportunities for Novel CNS Therapeutics

  2022 Clinical Pharmacology & Therapeutics article Neuroscience Barrier Structure and Function Studies Open access

  40

  citations
• Altered protein expression of membrane transporters in isolated cerebral microvessels and brain cortex of a rat Alzheimer's disease model

  2022 Neurobiology of Disease article Medicine Alzheimer's disease research and treatments Open access

  32

  citations
• The potential impact of CYP and UGT drug-metabolizing enzymes on brain target site drug exposure

  2023 Drug Metabolism Reviews article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access

  13

  citations
• Exploring Kp,uu,BBB values smaller than unity in remoxipride: A physiologically-based CNS model approach highlighting brain metabolism in drugs with passive blood-brain barrier transport

  2024 European Journal of Pharmaceutical Sciences article Neuroscience Barrier Structure and Function Studies Open access

  3

  citations
• Professor Margareta Hammarlund-Udenaes - A Humble Scientist Shaping Modern Neuropharmacokinetics

  2022 Pharmaceutical Research article Neuroscience Neurology and Historical Studies Open access

  0

  citations
• Exploring Kp,uu,BBB Values Smaller than Unity in Remoxipride: A Physiologically-Based CNS Model Approach Highlighting Brain Metabolism in Drugs with Passive Blood-Brain Barrier Transport

  2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Neuroscience Barrier Structure and Function Studies Open access

  0

  citations
• Mechanism-based PBPK Modeling Reveals Nonlinear Brain Pharmacokinetics of Fluvoxamine: Roles of Active Influx and Brain Metabolism

  2026 conference-paper Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access

  0

  citations
• The integrated Lei‐CNS PBPK‐PD model effectively predicts clozapine brain disposition and D 2 receptor occupancy in humans

  2026 British Journal of Clinical Pharmacology article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access

  0

  citations

9 results