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Effect of sphingosine and phytosphingosine ceramide ratio on lipid arrangement and barrier function in skin lipid models2023 Journal of Lipid Research article Pharmacology, Toxicology and Pharmaceutics Advancements in Transdermal Drug Delivery Open access
Andreea Nădăban, Jannik Rousel, Dounia El Yachioui, Gerrit S. Gooris, Charlotte M. Beddoes, Robert M. Dalgliesh, +3 more
36citations -
54208 Skin barrier function and epidermal ceramide composition characterized in patients with early-stage Mycosis Fungoides2024 Journal of the American Academy of Dermatology article Medicine Cutaneous lymphoproliferative disorders research Open access
Robert Rißmann, Selinde S. Wind, Catherine Mergen, Jannik Rousel, Andreea Nădăban, Rianne Rijneveld, +3 more
0citations -
Lesional Psoriasis is Associated With Alterations in the Stratum Corneum Ceramide Profile and Concomitant Decreases in Barrier Function2024 Experimental Dermatology article Immunology and Microbiology Psoriasis: Treatment and Pathogenesis Open access
Jannik Rousel, Catherine Mergen, M. Bergmans, Naomi B. Klarenbeek, Tessa Niemeyer‐van der Kolk, Martijn B. A. van Doorn, +2 more
15citations -
Increased Levels of Short-Chain Ceramides Modify the Lipid Organization and Reduce the Lipid Barrier of Skin Model Membranes2021 Langmuir article Biochemistry, Genetics and Molecular Biology Lipid Membrane Structure and Behavior Open access
Lorretta E. Uche, Gerrit S. Gooris, Joke A. Bouwstra, Charlotte M. Beddoes
46citations -
The skin barrier: An extraordinary interface with an exceptional lipid organization2023 Progress in Lipid Research article Pharmacology, Toxicology and Pharmaceutics Advancements in Transdermal Drug Delivery Open access cited by 1 patent
Joke A. Bouwstra, Andreea Nădăban, Wim Bras, Clare McCabe, Annette L. Bunge, Gerrit S. Gooris
173citations -
Fibroblast-derived matrix human skin equivalents reveal distinct roles for papillary and reticular fibroblasts in human skin barrier integrity and aging2026 Scientific Reports article Pharmacology, Toxicology and Pharmaceutics Advancements in Transdermal Drug Delivery Open access
Alesha Louis, Catherine Mergen, Marion H. Rietveld, Gaëlle Gendronneau, Nada Andre, Youcef Ben Khalifa, +4 more
1citations -
Multitargeted Approach for the Optimization of Morphogenesis and Barrier Formation in Human Skin Equivalents2021 International Journal of Molecular Sciences article Biochemistry, Genetics and Molecular Biology Skin and Cellular Biology Research Open access
Arnout Mieremet, Richard W.J. Helder, Andreea Nădăban, Walter A. Boiten, Gert S. Gooris, Abdoelwaheb El Ghalbzouri, +1 more
9citations -
Barrier lipid composition and response to plasma lipids: A direct comparison of mouse dorsal back and ear skin2020 Experimental Dermatology article Pharmacology, Toxicology and Pharmaceutics Advancements in Transdermal Drug Delivery Open access
Renata Martins Cardoso, Samira Absalah, Miranda Van Eck, Joke A. Bouwstra
9citations -
Skin barrier lipid enzyme activity in Netherton patients is associated with protease activity and ceramide abnormalities2020 Journal of Lipid Research article Biochemistry, Genetics and Molecular Biology Genetic and rare skin diseases. Open access cited by 1 patent
Jeroen van Smeden, Hanin Al-Khakany, Yichen Wang, Dani Visscher, Samira Absalah, Herman S. Overkleeft, +3 more
29citations -
Using molecular simulation to understand the skin barrier2022 Progress in Lipid Research article Pharmacology, Toxicology and Pharmaceutics Advancements in Transdermal Drug Delivery Open access
Parashara Shamaprasad, Chloe O. Frame, Timothy C. Moore, Christopher R. Iacovella, Joke A. Bouwstra, Annette L. Bunge, +1 more
45citations -
The phase behavior of skin-barrier lipids: A combined approach of experiments and simulations2024 Biophysical Journal article Biochemistry, Genetics and Molecular Biology Lipid Membrane Structure and Behavior Open access
Parashara Shamaprasad, Andreea Nădăban, Christopher R. Iacovella, Gerrit S. Gooris, Annette L. Bunge, Joke A. Bouwstra, +1 more
8citations -
Guselkumab treatment normalizes the stratum corneum ceramide profile and alleviates barrier dysfunction in psoriasis: results of a randomized controlled trial2024 Journal of Lipid Research article Immunology and Microbiology Psoriasis: Treatment and Pathogenesis Open access
Jannik Rousel, Catherine Mergen, M. Bergmans, Lisa J. Bruijnincx, Marieke L. de Kam, Naomi B. Klarenbeek, +4 more
11citations -
Improved organotypic skin model with reduced quantity of monounsaturated ceramides by inhibiting stearoyl-CoA desaturase-12021 Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids article Pharmacology, Toxicology and Pharmaceutics Advancements in Transdermal Drug Delivery Open access
Richard W.J. Helder, Jannik Rousel, Walter A. Boiten, Gerrit S. Gooris, Andreea Nădăban, Abdoelwaheb El Ghalbzouri, +1 more
11citations -
Skin of atopic dermatitis patients shows disturbed β-glucocerebrosidase and acid sphingomyelinase activity that relates to changes in stratum corneum lipid composition2020 Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids article Medicine Dermatology and Skin Diseases Open access
Daphne E.C. Boer, Jeroen van Smeden, Hanin Al-Khakany, Elizaveta V. Melnik, Rianne van Dijk, Samira Absalah, +6 more
41citations -
Perspective and Consensus Opinion: Good Practices for Using Organotypic Skin and Epidermal Equivalents in Experimental Dermatology Research2020 Journal of Investigative Dermatology article Biochemistry, Genetics and Molecular Biology Skin and Cellular Biology Research Open access
Ellen H. J. van den Bogaard, Duško Ilić, Sandrine Dubrac, Marjana Tomic‐Canic, Joke A. Bouwstra, Anna Celli, +1 more
32citations -
High concentration of the ester-linked ω-hydroxy ceramide increases the permeability in skin lipid model membranes2020 Biochimica et Biophysica Acta (BBA) - Biomembranes article Biochemistry, Genetics and Molecular Biology Lipid Membrane Structure and Behavior Open access
Lorretta E. Uche, Gerrit S. Gooris, Joke A. Bouwstra, Charlotte M. Beddoes
23citations -
The importance of ceramide headgroup for lipid localisation in skin lipid models2022 Biochimica et Biophysica Acta (BBA) - Biomembranes article Biochemistry, Genetics and Molecular Biology Lipid Membrane Structure and Behavior Open access
Charlotte M. Beddoes, Gert S. Gooris, David J. Barlow, Margaret Jayne Lawrence, Robert M. Dalgliesh, Marc Malfois, +2 more
17citations -
Epidermal 1‐ O‐acylceramides appear with the establishment of the water permeability barrier in mice and are produced by maturating keratinocytes2022 Lipids article Biochemistry, Genetics and Molecular Biology Sphingolipid Metabolism and Signaling Open access cited by 1 patent
Mariona Rabionet, Pauline Bernard, Mélanie Pichery, Christian Marsching, Aline Bayerle, Shaalee Dworski, +14 more
8citations -
Phytosphingosine ceramide mainly localizes in the central layer of the unique lamellar phase of skin lipid model systems2022 Journal of Lipid Research article Pharmacology, Toxicology and Pharmaceutics Advancements in Transdermal Drug Delivery Open access
Andreea Nădăban, Gerrit S. Gooris, Charlotte M. Beddoes, Robert M. Dalgliesh, Joke A. Bouwstra
21citations -
199 Alterations in the stratum corneum ceramide profile and barrier dysfunction in lesional psoriasis are alleviated by guselkumab treatment2024 Journal of Investigative Dermatology article Immunology and Microbiology Psoriasis: Treatment and Pathogenesis Open access
Jannik Rousel, Catherine Mergen, M. Bergmans, Lisa J. Bruijnincx, M. de Kam, Naomi B. Klarenbeek, +4 more
0citations -
Enhancing Human Skin Penetration with Biodegradable Enzymatic Nanomotors2026 ACS Nano article Pharmacology, Toxicology and Pharmaceutics Advancements in Transdermal Drug Delivery Open access
Carles Prado-Morales, Taco Waaijman, Ines Macías-Tarrío, Cristián Huck‐Iriart, Tiziana Russo, Joël Gálvez-Savoca, +3 more
0citations -
Arrangement of Ceramides in the Skin: Sphingosine Chains Localize at a Single Position in Stratum Corneum Lipid Matrix Models2020 Langmuir article Biochemistry, Genetics and Molecular Biology Lipid Membrane Structure and Behavior Open access
Charlotte M. Beddoes, Gert S. Gooris, Fabrizia Foglia, Delaram Ahmadi, David J. Barlow, Margaret Jayne Lawrence, +2 more
27citations -
The Importance of Free Fatty Chain Length on the Lipid Organization in the Long Periodicity Phase2021 International Journal of Molecular Sciences article Biochemistry, Genetics and Molecular Biology Lipid Membrane Structure and Behavior Open access
Charlotte M. Beddoes, Denise E. Rensen, Gert S. Gooris, Marc Malfois, Joke A. Bouwstra
20citations