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Novel YAP1/TAZ pathway inhibitors identified through phenotypic screening with potent anti-tumor activity via blockade of GGTase-I / Rho-GTPase signaling2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Hippo pathway signaling and YAP/TAZ Open access
Keith Graham, Philip Lienau, Benjamin Bader, Stefan Prechtl, Jan Naujoks, Ralf Lesche, +32 more
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A genome-wide CRISPR/Cas phenotypic screen for modulators of DUX4 cytotoxicity reveals screen complications2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Muscle Physiology and Disorders Open access
Ator Ashoti, Francesco Limone, Melissa van Kranenburg, Anna Alemany, Mirna Lilian Baak, Judith Vivié, +4 more
2citations -
Systematic assessment of transcriptomic and phenotypic biological profiling for mechanism-based hazard assessment using target-annotated reference chemicals in renal proximal tubular epithelial cells2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Computer Science Computational Drug Discovery Methods Open access
Hugo W van Kessel, Marlene Wedler, Palle Steen Helmke, Dace Zigure, Stephen Ferguson, Joshua Harrill, +5 more
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A Framework for NGN1-Induced Sensory Neuron Differentiation for Disease Modelling and Drug Screening2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Pluripotent Stem Cells Research Open access
Anika Neureiter, Marlene Menke, Veronica Donde, Cedric Guenther, Lennart Mueller, Florian Kraft, +10 more
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Industrialization of three-dimensional hiPSC-cardiac microtissues for high-throughput cardiac safety and drug discovery screening2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Pluripotent Stem Cells Research Open access
Tessa de Korte, Georgios Kosmidis, Benoit Samson-Couterie, Mervyn P.H. Mol, Ruben W.J. van Helden, Viviana Meraviglia, +7 more
1citations -
A fluorescence-based sensor screen identifies MED12 as a potential microsatellite instability regulator in colon cancer2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Genetic factors in colorectal cancer Open access
João M. Fernandes Neto, Subramanian Venkatesan, Matheus de Souza Dias, Cor Lieftink, Ben Morris, Kaspar Bresser, +6 more
0citations -
Modeling Hepatocellular Carcinoma and its microenvironment on a chip Hepatocellular carcinoma PDChip2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Engineering 3D Printing in Biomedical Research Open access
Orsola Mocellin, Stéphane Treillard, Abbie Robinson, Aleksandra Olczyk, Thomas Olivier, Chee Ping Ng, +9 more
1citations -
SynCom101: A web-based platform for the standardized design of functionally tailored synthetic microbial communities2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Gut microbiota and health
Jiayi Jing, Siemen Rockx, Aster Liu, Chrats Melkonian, Jos M. Raaijmakers, Paolina Garbeva, +1 more
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Patients with Chromosome 11q-abberations are Characterized by a Combined Primary Immunodeficiency Involving Both B- and T-lymphocytes2021 Research Square preprint Immunology and Microbiology Immunodeficiency and Autoimmune Disorders Open access
Elise J. Huisman, A. Rick Brooimans, Samone Mayer, Marieke Joosten, Louis J Bont, Elisabeth L. M. Rammeloo, +6 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Anne Schreuder, Klaas de Lint, Mariana M. Gois, Rosalie A. Kampen, Marta San Martín Alonso, Ilse Nootenboom, +3 more
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Closing the Loop: Autonomous High-Throughput Strain Characterisation from Frozen Cell Bank to Product Assay2023 Research Square preprint Biochemistry, Genetics and Molecular Biology Microbial Metabolic Engineering and Bioproduction Open access
Laura M. Helleckes, Debora Puchta, Hannah Czech, Holger Morschett, Bertram Geinitz, Wolfgang Wiechert, +1 more
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Reanalysis of whole-exome sequencing (WES) data of children with neurodevelopmental disorders in a standard patient care context2023 Research Square preprint Biochemistry, Genetics and Molecular Biology Genomics and Rare Diseases Open access
Michelle van Slobbe, Arie van Haeringen, Lisenka E.L.M. Vissers, Emilia K. Bijlsma, Julie W. Rutten, Manon Suerink, +3 more
4citations -
Novel kinome profiling technology reveals drug treatment is patient and 2D/3D model dependent in GBM2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Glioma Diagnosis and Treatment Open access
Federica Fabro, Nynke M. Kannegieter, Erik L. de Graaf, Karla C. S. Queiroz, Martine L.M. Lamfers, Anna Ressa, +1 more
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Cercosporamide inhibits bone morphogenetic protein receptor type I kinase activity in zebrafish2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology TGF-β signaling in diseases Open access
Jelmer Hoeksma, Gerard C.M. van der Zon, Peter ten Dijke, Jeroen den Hertog
0citations -
Chronic exposure to low-concentration urban PM2.5 accelerates maladaptive repair after ischemic injury via mitochondrial dysfunction and lysosomal stress2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Acute Kidney Injury Research Open access
Peiqi Sun, Antônio Carlos Parra, Talita Rojas Sanches, Caroline Fernanda Hei Wikuats, Loes M. Butter, Nike Claessen, +15 more
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Pollen sequencing reveals barriers and aberrant patterns of recombination in interspecific tomato hybrids2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Agricultural and Biological Sciences Chromosomal and Genetic Variations Open access
Roven Rommel Fuentes, Ronald Nieuwenhuis, Jihed Chouaref, Thamara Hesselink, W. van Dooijeweert, Hetty C. van den Broeck, +8 more
2citations -
Probing immune signatures of conjugated pattern recognition receptor ligands identifies chimeras with adjuvant and antitumor activity2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Immunology and Microbiology Immunotherapy and Immune Responses Open access
Špela Janež, Samo Guzelj, Marcela Šišić, Ruža Frkanec, Stane Pajk, Lenny Burgmeijer, +2 more
1citations