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6P Response and survival according to the interferon-gamma (IFN-γ) signature and tumor mutational burden (tmb) in the PRADO trial testing neoadjuvant ipilimumab and nivolumab in stage III melanoma
Reijers, P. Dimitriadis, J.J. Traets, Robyn P.M. Saw, J.M. Versluis, Thomas E. Pennington, +14 more
4citations -
Efficacy of Pembrolizumab and Biomarker Analysis in Patients with WGS-Based Intermediate to High Tumor Mutational Load: Results from the Drug Rediscovery Protocol
Birgit S. Geurts, Laurien Joanna Zeverijn, Lindsay V.M. Leek, Jade M. van Berge Henegouwen, Louisa Rose Hoes, Hanneke van der Wijngaart, +15 more
4citations -
Tobacco Smoking-Related Mutational Signatures in Classifying Smoking-Associated and Nonsmoking-Associated NSCLC2022 Journal of Thoracic Oncology article Biochemistry, Genetics and Molecular Biology Cancer Genomics and Diagnostics Open access
Sophie M. Ernst, Joanne M. Mankor, Job van Riet, Jan H. von der Thüsen, Hendrikus Jan Dubbink, Joachim G.J.V. Aerts, +4 more
48citations -
Human induced pluripotent stem cells display a similar mutation burden as embryonic pluripotent cells in vivo2022 iScience article Biochemistry, Genetics and Molecular Biology Pluripotent Stem Cells Research Open access
Karlijn Hasaart, Freek Manders, Joske Ubels, Mark Verheul, Markus J. van Roosmalen, Niels M. Groenen, +4 more
9citations -
Checkpoint Blockade Combinations in Tumor Mutational Burden/Load-High Tumors: Insights from the Atezolizumab + Bevacizumab and Nivolumab + Ipilimumab Cohorts in the Drug Rediscovery Protocol
Karlijn Verkerk, Soemeya F. Haj Mohammad, Laurien Joanna Zeverijn, Birgit S. Geurts, Ilse A.C. Spiekman, Florentine A.J. Verbeek, +11 more
2citations -
Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional longevity2020 Aging Cell article Biochemistry, Genetics and Molecular Biology Genomics and Rare Diseases Open access cited by 1 patent
Danielle Gutman, Gabriel Arie Lidzbarsky, Sofiya Milman, Tina Gao, Patrick Sin‐Chan, Claudia G. Gonzaga-Jauregui, +4 more
13citations -
Tumor mutational load, CD8+ T cells, expression of PD-L1 and HLA class I to guide immunotherapy decisions in NSCLC patients2020 Cancer Immunology Immunotherapy article Medicine Cancer Immunotherapy and Biomarkers Open access cited by 1 patent
Daan P. Hurkmans, Merian E. Kuipers, Ronald van Marion, Ron H.J. Mathijssen, Piet E. Postmus, Pieter Sicco Hiemstra, +3 more
96citations -
257P Efficacy of pembrolizumab in pre-treated breast cancer harboring high mutational load 140-290 – results from the Drug Rediscovery Protocol (DRUP)
Laurien Joanna Zeverijn, Birgit S. Geurts, Jade M. van Berge Henegouwen, Louisa Rose Hoes, Hanneke van der Wijngaart, G.F. de Wit, +8 more
0citations -
Hypomorphic RAG deficiency: impact of disease burden on survival and thymic recovery argues for early diagnosis and HSCT2022 Blood article Immunology and Microbiology Immunodeficiency and Autoimmune Disorders Open access
Catharina Schuetz, Markus Johannes Ege, Jolan Eszter Walter, Maaike Kusters, Austen J. J. Worth, Jennifer Ann Kanakry, +34 more
32citations -
CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden2023 Journal for ImmunoTherapy of Cancer article Medicine Cancer Immunotherapy and Biomarkers Open access
Jitske van den Bulk, Manon van der Ploeg, Marieke E. Ijsselsteijn, Dina Ruano, Ruud van der Breggen, Rebekka Duhen, +6 more
29citations -
Elenestinib, an Investigational, Next Generation KIT D816V Inhibitor, Reduces Mast Cell Burden, Improves Symptoms, and Has a Favorable Safety Profile in Patients with Indolent Systemic Mastocytosis: Analysis of the Harbor Trial
Tsewang Tashi, Olivier Hermine, Mariana Castells, Mar Guilarte, Vito Sabato, Marcus Maurer, +26 more
19citations -
Breast cancer genomes from CHEK2 c.1100delC mutation carriers lack somatic TP53 mutations and display a unique structural variant size distribution profile2023 Breast Cancer Research article Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Marcel Smid, Marjanka K. Schmidt, Wendy J. C. Prager‐van der Smissen, Kirsten Ruigrok-Ritstier, Maartje A. C. Schreurs, Sten Cornelissen, +8 more
10citations