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Non-apoptotic FAS signaling controls mTOR activation and extrafollicular maturation in human B cells2024 Science Immunology article Immunology and Microbiology T-cell and B-cell Immunology Open access
Julian Staniek, Geoffroy Andrieux, Melanie Boerries, Iga Janowska, Manuel Fuentes, Paula Díez, +37 more
25citations -
Leucine Reconstitutes Phagocytosis-Induced Cell Death in E. coli-Infected Neonatal Monocytes—Effects on Energy Metabolism and mTOR Signaling2021 International Journal of Molecular Sciences article Biochemistry, Genetics and Molecular Biology Cell death mechanisms and regulation Open access
Stephan Dreschers, Kim Ohl, Julia Möllmann, Klaus Tenbrock, Thorsten W Orlikowsky
5citations -
2,8-Dihydroxyadenine-induced nephropathy causes hexosylceramide accumulation with increased mTOR signaling, reduced levels of protective SirT3 expression and impaired renal mitochondrial function2023 Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease article Medicine Chronic Kidney Disease and Diabetes Open access
Julia Moellmann, Katja Krueger, Dickson W.L. Wong, Barbara M. Klinkhammer, Eva Miriam Buhl, Jonas Dehairs, +7 more
19citations -
Personalized Medicine Approach in a DCM Patient with LMNA Mutation Reveals Dysregulation of mTOR Signaling2022 Journal of Personalized Medicine article Medicine Cardiomyopathy and Myosin Studies Open access
Balram Neupane, Kabita Pradhan, Audrey Ortega-Ramírez, Parwez Aidery, Vytautas Kučikas, Matthias Marks, +6 more
11citations -
German longevity study reveals novel rare pro-longevity alleles clustering in mTOR signaling pathway2025 GeroScience article Biochemistry, Genetics and Molecular Biology Genetics, Aging, and Longevity in Model Organisms Open access
Daniel Kolbe, Janina Dose, Pasquale C. Putter, Malte Ziemann, Matthias Laudes, P. Eline Slagboom, +3 more
4citations -
The sodium‐glucose co‐transporter‐2 inhibitor ertugliflozin modifies the signature of cardiac substrate metabolism and reduces cardiac mTOR signalling, endoplasmic reticulum stress and apoptosis
Julia Moellmann, Pascal A. Mann, Ben Arpad Kappel, Florian Kahles, Barbara M. Klinkhammer, Peter Boor, +5 more
52citations -
Multi-omics reveals global signaling rewiring and identifies Activin A-induced dysregulation of FOS/Activator Protein 1 as a novel target in Fibrodysplasia ossificans progressiva2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Heterotopic Ossification and Related Conditions Open access
Marius Wits, Nerea Gomez-Suarez, Alexandre Deber, Nicole Farfán, Fjodor T. Bekedam, Bharath K. Sampadi, +8 more
0citations -
Models of KPTN-related disorder implicate mTOR signalling in cognitive and overgrowth phenotypes2023 Brain article Biochemistry, Genetics and Molecular Biology Genetics and Neurodevelopmental Disorders Open access
Maria O. Levitin, Lettie E. Rawlins, Gabriela Sánchez-Andrade, Osama A. Arshad, Stephan C. Collins, Stephen J. Sawiak, +35 more
12citations -
Mouse and cellular models of KPTN -related disorder implicate mTOR signalling in cognitive and progressive overgrowth phenotypes2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Genetics and Neurodevelopmental Disorders Open access
Maria O. Levitin, Lettie E. Rawlins, Gabriela Sánchez-Andrade, Osama A. Arshad, Stephan C. Collins, Stephen J. Sawiak, +35 more
1citations -
Multi-omics analyses of cancer-linked clinical salmonellae reveal bacterial-induced host metabolic shift and mTOR-dependent cell transformation2024 Cell Reports article Agricultural and Biological Sciences Salmonella and Campylobacter epidemiology Open access
Virginie Stévenin, Claudia E. Coipan, Janneke W. Duijster, Daphne M. van Elsland, Linda Voogd, Lise Bigey, +8 more
5citations -
Simultaneous targeting of AMPK and mTOR is a novel therapeutic strategy against prostate cancer2024 Cancer Letters article Biochemistry, Genetics and Molecular Biology PI3K/AKT/mTOR signaling in cancer Open access
Gangyin Zhao, Gabriel Forn‐Cuní, Marvin Scheers, Pier Pieterszoon Lindenbergh, Jie Yin, Quint C. van Loosen, +3 more
22citations -
Simultaneous targeting of AMPK and mTOR is a novel therapeutic strategy against prostate cancer2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology PI3K/AKT/mTOR signaling in cancer Open access
Gangyin Zhao, Gabriel Forn‐Cuní, Marvin Scheers, Pier Pieterszoon Lindenbergh, Jie Yin, Quint C. van Loosen, +3 more
2citations -
mTORC1 signaling in antigen-presenting cells of the skin restrains CD8+ T cell priming2022 Cell Reports article Immunology and Microbiology Immunotherapy and Immune Responses Open access
Leonard R. Pelgrom, Thiago A. Patente, Frank Otto, Lonneke V. Nouwen, Arifa Ozir‐Fazalalikhan, Alwin J. van der Ham, +4 more
8citations -
Deletion of mTOR in liver epithelial cells enhances hepatic metastasis of colon cancer2021 The Journal of Pathology article Biochemistry, Genetics and Molecular Biology PI3K/AKT/mTOR signaling in cancer Open access
Long R. Jiao, Roman Eickhoff, Sandra Jumpertz, Merve Erdem, Andreas Kroh, Hans Duimel, +7 more
7citations -
Dyr726, a brain-penetrant inhibitor of PI3Kα, Type III receptor tyrosine kinases, and WNT signaling2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology PI3K/AKT/mTOR signaling in cancer Open access
Vasudha Tandon, Alessandra Fistrovich, Joaquina Nogales, Febe Ferro, Samantha Rokey, Carly R. Cabel, +25 more
0citations -
Deciphering the Signaling Network Landscape of Breast Cancer Improves Drug Sensitivity Prediction2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology PI3K/AKT/mTOR signaling in cancer Open access
Marco Tognetti, Attila Gábor, Mi Yang, Valentina Cappelletti, Jonas Windhager, Konstantina Charmpi, +5 more
5citations -
Enhanced inflammatory response mediated by parenchymal cells associates with resistance towards mTOR inhibition2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology PI3K/AKT/mTOR signaling in cancer Open access
Long R. Jiao, Roman Eickhoff, Sandra Jumpertz, Merve Erdem, Andreas Kroh, Hans Duimel, +6 more
0citations -
Hepatocellular loss of mTOR aggravates tumor burden in nonalcoholic steatohepatitis-related HCC2023 Neoplasia article Biochemistry, Genetics and Molecular Biology PI3K/AKT/mTOR signaling in cancer Open access
Andreas Kroh, Jeanette Walter, Athanassios Fragoulis, Diana Möckel, Twan Lammers, Fabian M. Kiessling, +10 more
8citations -
MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer2023 The Journal of Experimental Medicine article Biochemistry, Genetics and Molecular Biology PI3K/AKT/mTOR signaling in cancer Open access
Jinhyuk Bhin, Julia Yemelyanenko, Xue Chao, Sjoerd Klarenbeek, Mark Opdam, Yuval Malka, +18 more
26citations