Papers matching “disease heterogeneity” 1,109
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The need and benefit of immune monitoring to define patient and disease heterogeneity, mechanisms of therapeutic action and efficacy of intervention therapy for precision medicine in type 1 diabetes9citations
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Single-Cell Analysis of Refractory Celiac Disease Demonstrates Inter- and Intra-Patient Aberrant Cell Heterogeneity2022 Cellular and Molecular Gastroenterology and Hepatology article Medicine Celiac Disease Research and Management Open access
Tessa Dieckman, Mette Schreurs, Ahmed Essam Mahfouz, Yvonne Kooy–Winkelaar, Andra Neefjes‐Borst, Gerd Bouma, +1 more
18citations -
Unraveling heterogeneity within ACPA-negative rheumatoid arthritis: the subgroup of patients with a strong clinical and serological response to initiation of DMARD treatment favor disease resolution2022 Arthritis Research & Therapy article Medicine Rheumatoid Arthritis Research and Therapies Open access
Marloes Verstappen, Hanna W. van Steenbergen, Pascal H P de Jong, Annette H M van der Helm–van Mil
14citations -
Cell-projected Phenotypes Link Transcriptional and Phenotypic Heterogeneity in Alzheimer’s Disease2026 SSRN Electronic Journal preprint Biochemistry, Genetics and Molecular Biology Single-cell and spatial transcriptomics Open access
Riley J. Mangan, Gerard A. Bouland, Tim Schubert, Danish Anwer, Judy Bai, Gülfem Ekiz, +6 more
0citations -
Interstitial Lung Disease in Patients With Systemic Sclerosis: Toward Personalized-Medicine-Based Prediction and Drug Screening Models of Systemic Sclerosis-Related Interstitial Lung Disease (SSc-ILD)
Padmini P. S. J. Khedoe, Emiel R. Marges, Pieter Sicco Hiemstra, Maarten K. Ninaber, Miranda Geelhoed
24citations -
Identification of a Disease-Associated Network of Intestinal Immune Cells in Treatment-Naive Inflammatory Bowel Disease2022 Frontiers in Immunology article Biochemistry, Genetics and Molecular Biology Inflammatory Bowel Disease Open access
Vincent van Unen, Laura F. Ouboter, Na Li, Mette Schreurs, Tamim Abdelaal, Yvonne Kooy–Winkelaar, +13 more
33citations -
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology2024 Nature article Biochemistry, Genetics and Molecular Biology Genetic Associations and Epidemiology Open access
Ken Suzuki, Konstantinos Hatzikotoulas, Lorraine Southam, Henry J. Taylor, Xianyong Yin, Kimberly Lorenz, +93 more
594citations -
Endothelial and Inflammation Biomarker Profiles at Diagnosis Reflecting Clinical Heterogeneity and Serving as a Prognostic Tool for Treatment Response in Two Independent Cohorts of Patients With Juvenile Dermatomyositis2020 Arthritis & Rheumatology article Medicine Inflammatory Myopathies and Dermatomyositis Open access
Judith Wienke, Lauren M. Pachman, Gabrielle A Morgan, Joo Guan Yeo, Maria C. Amoruso, Victoria Hans, +9 more
43citations -
Conceptual framework for the definition of disease modification in systemic sclerosis and potential implications for drug development and clinical study design2026 Annals of the Rheumatic Diseases review Medicine Systemic Sclerosis and Related Diseases Open access
Jörg H. W. Distler, Shervin Assassi, Armando Gabrielli, Yannick Allanore, Lorinda S Chung, Maurizio Cutolo, +30 more
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Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications2023 medRxiv preprint Biochemistry, Genetics and Molecular Biology Genetic Associations and Epidemiology Open access
Ken Suzuki, Konstantinos Hatzikotoulas, Lorraine Southam, Henry J. Taylor, Xianyong Yin, Kim Lorenz, +93 more
21citations -
Disentangling heterogeneity in contemporary undifferentiated arthritis – A large cohort study using latent class analysis2023 Seminars in Arthritis and Rheumatism article Medicine Rheumatoid Arthritis Research and Therapies Open access
Nikolet K den Hollander, Marloes Verstappen, Bastiaan T van Dijk, Annette H M van der Helm–van Mil, Hanna W. van Steenbergen
6citations -
Expanding the Genetic and Phenotypic Spectrum of POLRMT ‐Related Mitochondrial Disease2025 Clinical Genetics article Biochemistry, Genetics and Molecular Biology Mitochondrial Function and Pathology Open access
Mahmoud R. Fassad, Sebastian Valenzuela, Monika Oláhová, Jack J. Collier, Charlotte V. Y. Knowles, Miriam Elbracht, +14 more
4citations