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Protocol, rationale and design of BE-PEOPLE (Bedaquiline enhanced exposure prophylaxis for LEprosy in the Comoros): a cluster randomized trial on effectiveness of rifampicin and bedaquiline as post-exposure prophylaxis of leprosy contacts
Younoussa Assoumani, Said Nourdine Samidine, Auke T. Bergeman, Alberto Piubello, Nissad Attoumani, Silahi Halifa Grillone, +14 more
22citations -
Predictions of Bedaquiline and Pretomanid Target Attainment in Lung Lesions of Tuberculosis Patients using Translational Minimal Physiologically Based Pharmacokinetic Modeling2023 Clinical Pharmacokinetics article Medicine Antibiotics Pharmacokinetics and Efficacy Open access
Krina Mehta, Tingjie Guo, Piet H. van der Graaf, J. G. Coen van Hasselt
17citations -
Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages a pathway to increased bedaquiline resistance2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Tuberculosis Research and Epidemiology Open access
Adam J. Fountain, Jan Böhning, Stephen H. McLaughlin, Tomos E. Morgan, Paul H. Edelstein, Mark A. Troll, +4 more
4citations -
Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages increased bedaquiline resistance2025 Proceedings of the National Academy of Sciences article Medicine Tuberculosis Research and Epidemiology Open access
Adam J. Fountain, Jan Böhning, Stephen H. McLaughlin, Tomos E. Morgan, Paul H. Edelstein, Mark A. Troll, +4 more
7citations -
Predictions of Bedaquiline Central Nervous System Exposure in Patients with Tuberculosis Meningitis Using Physiologically based Pharmacokinetic Modeling2024 Clinical Pharmacokinetics article Medicine Antibiotics Pharmacokinetics and Efficacy Open access
Krina Mehta, Pavel Balazki, Piet H. van der Graaf, Tingjie Guo, J. G. Coen van Hasselt
14citations -
Model‐based dose optimization framework for bedaquiline, pretomanid and linezolid for the treatment of drug‐resistant tuberculosis2023 British Journal of Clinical Pharmacology article Medicine Tuberculosis Research and Epidemiology Open access
Krina Mehta, Tingjie Guo, Piet H. van der Graaf, J. G. Coen van Hasselt
10citations -
Successful Translational Prediction of Bedaquiline's Phase 2a Clinical Trial Results against Tuberculosis: The Zebrafish as a New Approach Methodology2026 Clinical Pharmacology & Therapeutics article Biochemistry, Genetics and Molecular Biology Zebrafish Biomedical Research Applications Open access
Bart van Lieshout, Aanisah Hanuun, J. G. Coen van Hasselt, Rob Christiaan van Wijk
1citations -
Bedaquiline for multidrug-resistant TB in paediatric patients2021 The International Journal of Tuberculosis and Lung Disease article Medicine Tuberculosis Research and Epidemiology Open access
Ronelle Moodliar, Valentina Aksenova, M.V.G. Frias, J. van de Logt, Stefaan Rossenu, E. Birmingham, +5 more
27citations -
Development of Human Cell-Based In Vitro Infection Models to Determine the Intracellular Survival of Mycobacterium avium2022 Frontiers in Cellular and Infection Microbiology article Medicine Mycobacterium research and diagnosis Open access
Gül Kilinç, Kimberley V. Walburg, Kees L. M. C. Franken, Merel L. Valkenburg, Alexandra Aubry, Mariëlle C. Haks, +2 more
9citations -
Accelerating drug development in infectious diseases using zebrafish disease models supported by pharmacokinetic-pharmacodynamic modeling as new approach methodology (NAM)2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Zebrafish Biomedical Research Applications Open access
Gabriel Forn‐Cuní, Bart van Lieshout, Bjørn E. V. Koch, Cristina Villellas, Stijn Van Asten, Ellen A. Lanckacker, +7 more
1citations -
In vitro pharmacokinetics and pharmacodynamics of the diarylquinoline TBAJ-587 and its metabolites against Mycobacterium tuberculosis2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Tuberculosis Research and Epidemiology Open access
Diana A. Aguilar-Ayala, Maxime Eveque, Albin A. M. Leding, Lindsay Sonnekalb, Ana Picó, Nicolas Willand, +3 more
1citations -
Accelerating drug development using zebrafish disease models supported by pharmacokinetic-pharmacodynamic modeling as new approach methodology (NAM)2026 Zenodo (CERN European Organization for Nuclear Research) dataset Biochemistry, Genetics and Molecular Biology Zebrafish Biomedical Research Applications Open access
Gabriel Forn‐Cuní, Bart van Lieshout, Bjørn E. V. Koch, Cristina Villellas, Stijn Van Asten, Dina Berlina, +8 more
0citations
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