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CRISPR activation screening identifies VGLL3 and GATA2 as transcriptional regulators of PD-L12021 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Cancer Immunotherapy and Biomarkers Open access
Ruud H. M. Wijdeven, Birol Cabukusta, Xueer Qiu, Daniel Borràs, Yun Liang, Jacques Neefjes
0citations -
Bidirectional crosstalk between epithelial-mesenchymal plasticity and IFNγ-induced PD-L1 expression promotes tumor progression2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Cancer Cells and Metastasis Open access
Gerhard A. Burger, Daphne Nesenberend, Carlijn M. Lems, Sander C. Hille, Joost B. Beltman
1citations -
UV1 cancer vaccine in pembrolizumab-treated patients with recurrent or metastatic PD-L1 positive head and neck squamous cell carcinoma: results from the randomized phase 2 FOCUS trial
Anna Paula Brandt, Konrad Friedrich Klinghammer, Christoph Schultheiß, Lisa Paschold, Claudia Wickenhauser, Marcus Bauer, +17 more
1citations -
OX40 agonism enhances efficacy of PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Cancer Immunotherapy and Biomarkers Open access
Guillaume Beyrend, Tetje Cornelia van der Sluis, Esmé T.I. van der Gracht, Tamim Abdelaal, Simon P. Jochems, Robert A. Belderbos, +16 more
0citations -
TIGIT drives the immunosuppressive environment by downregulation of metalloproteinases MMP2 and MMP14 in perihilar cholangiocarcinoma2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Cholangiocarcinoma and Gallbladder Cancer Studies Open access
Lara Rosaline Heij, Konrad Reichel, Willem de Koning, Jan Bednarsch, Xiuxiang Tan, Julia Campello Deierl, +13 more
0citations -
Tumour-derived factors prime microglia for immune checkpoint-mediated T-cell regulation2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Neuroscience Neuroinflammation and Neurodegeneration Mechanisms Open access
Luca D Schreurs, Jessica Barz, Trong-Hieu Nguyen, Jule Schmedding, Liudmila Lobastova, Patrick Hoelker, +9 more
0citations -
A lymph node-to-tumour PDL1 + macrophage circuit antagonizes dendritic cell immunotherapy2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Immunology and Microbiology Immunotherapy and Immune Responses Open access
Jenny Sprooten, Isaure Vanmeerbeek, Angeliki Datsi, Jannes Govaerts, Daniel Borràs, Stefan Naulaerts, +17 more
4citations -
Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Colorectal Cancer Treatments and Studies Open access
Christina Plattner, Giorgia Lamberti, Peter Blattmann, Alexander Kirchmair, Dietmar Rieder, Zuzana Loncová, +23 more
0citations -
Inflammatory signature and restriction of adaptive immunity are associated with unfavorable outcomes on immune checkpoint blockade in patients with advanced head and neck squamous cell carcinoma
Lisa Paschold, Christoph Schultheiß, Paul Schmidt-Barbo, Konrad Friedrich Klinghammer, Dennis Hahn, Mareike Tometten, +8 more
0citations -
PCSK9 affects expression of key surface proteins in human pancreatic beta cells through intra- and extracellular regulatory circuits2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Pancreatic function and diabetes Open access
Kevin Saitoski, Maria Ryaboshapkina, Ghaith M. Hamza, Andrew F. Jarnuczak, Claire Berthault, Françoise Carlotti, +7 more
1citations -
Gut microbiota mediates trafficking of intestinal T cells to the brain to exacerbate neuroinflammation after ischemic stroke2025 Research Square preprint Neuroscience Neuroinflammation and Neurodegeneration Mechanisms Open access
Zhuang Li, Nannan Guo, Xiangyu Zuo, Jinlian Shao, Fabing Zhang, Yu Xiao, +19 more
0citations -
Long-term survival after neoadjuvant low-dose ipilimumab plus high-dose nivolumab in resectable stage III melanoma: the 5-year survival-update and biomarker analysis from the PRADO-trial
Christian U. Blank, Lotte L. Hoeijmakers, Petros Dimitriadis, S C M A Wijnen, Irene L. M. Reijers, Marta López‐Yurda, +37 more
1citations -
Microbial Invasion and Immunosuppression Drives Adenoma Progression in Early Colorectal Cancer Development2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Gut microbiota and health Open access
Wei Liang, Lisa Falk, Daniele Lucarelli, Philipp Putze, Amira Metwaly, Yiran Zheng, +13 more
0citations -
Temporal and spatial composition of the tumor microenvironment predicts response to immune checkpoint inhibition2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Cancer Immunotherapy and Biomarkers Open access
Noah F. Greenwald, Iris Nederlof, Daisy Yi Ding, Seongyeol Park, Alex Kong, Kathleen E. Houlahan, +29 more
7citations