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Deubiquitinating activity of SARS-CoV-2 papain-like protease does not influence virus replication or innate immune responses in vivo
Mariska van Huizen, Jonna R. Bloeme - ter Horst, Heidi L. M. De Gruyter, Paul P. Geurink, Gerbrand J. van der Heden van Noort, Robert C. M. Knaap, +8 more
23citations -
SARS ‐ C o V ‐2‐infected human airway epithelial cell cultures uniquely lack interferon and immediate early gene responses caused by other coronaviruses2024 Clinical & Translational Immunology article Medicine SARS-CoV-2 and COVID-19 Research Open access
Ying Wang, Melissa Thaler, Clarisse Salgado‐Benvindo, Nathan Ly, Anouk A. Leijs, Dennis K. Ninaber, +6 more
6citations -
The Main Protease of Middle East Respiratory Syndrome Coronavirus Induces Cleavage of Mitochondrial Antiviral Signaling Protein to Antagonize the Innate Immune Response
Mariska van Huizen, Xavier Martinez Vendrell, Heidi L. M. De Gruyter, A. Linda Boomaars‐van der Zanden, Eric J. Snijder, Marjolein Kikkert, +1 more
9citations -
R-Propranolol Has Broad-Spectrum Anti-Coronavirus Activity and Suppresses Factors Involved in Pathogenic Angiogenesis2023 International Journal of Molecular Sciences article Medicine SARS-CoV-2 and COVID-19 Research Open access
Melissa Thaler, Clarisse Salgado‐Benvindo, Anouk A. Leijs, Ali Taş, Dennis K. Ninaber, Jack L. Arbiser, +2 more
9citations -
HCoV-229E Mpro Suppresses RLR-Mediated Innate Immune Signalling Through Cleavage of NEMO and Through Other Mechanisms2025 International Journal of Molecular Sciences article Immunology and Microbiology interferon and immune responses Open access
Xavier Martiáñez–Vendrell, Puck B. van Kasteren, Sebenzile K. Myeni, Marjolein Kikkert
6citations -
Structure–function analysis of the nsp14 N7–guanine methyltransferase reveals an essential role in Betacoronavirus replication2021 Proceedings of the National Academy of Sciences article Medicine SARS-CoV-2 and COVID-19 Research Open access cited by 1 patent
Natacha S. Ogando, Priscila El Kazzi, Jessika C. Zevenhoven-Dobbe, Brenda W. Bontes, Alice Decombe, Clara C. Posthuma, +5 more
53citations -
α‑Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment2020 Journal of Medicinal Chemistry article Medicine SARS-CoV-2 and COVID-19 Research Open access cited by 37 patents
Linlin Zhang, Daizong Lin, Yuri Kusov, Yong Nian, Qingjun Ma, Jiang Wang, +8 more
616citations -
Dynamic data-driven meta-analysis for prioritisation of host genes implicated in COVID-192020 Scientific Reports article Biochemistry, Genetics and Molecular Biology Bioinformatics and Genomic Networks Open access
Nick Parkinson, Natasha Rodgers, Max Head Fourman, Bo Wang, Marie Zechner, Maaike C. Swets, +5 more
50citations -
Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis2023 PLoS Pathogens article Agricultural and Biological Sciences Animal Virus Infections Studies Open access
Ben A. Bailey-Elkin, Robert C. M. Knaap, Anuradha De Silva, Ilse M. Boekhoud, Sandra TM Mous, Niek van Vught, +4 more
10citations
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