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PDE3A-SLFN12 Molecular Glues Target Multiple KIT D816V Cell Types in Preclinical Models of Mast Cell Malignancies2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Immunology and Microbiology Mast cells and histamine Open access
Xuhuang Fu, Anne Kaiser, Payal Chawla, Axel Choidas, Peter Habenberger, Tiago Maié, +17 more
0citations -
Nintedanib Targets KIT D816V Neoplastic Cells Derived from Induced Pluripotent Stem cells of Systemic Mastocytosis2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Immunology and Microbiology Mast cells and histamine Open access
Marcelo A. S. Toledo, Malrun Gatz, Stephanie Sontag, Karoline Veronika Gleixner, Gregor Eisenwort, Kristina Feldberg, +21 more
4citations -
Elenestinib, an Investigational, Next Generation KIT D816V Inhibitor, Reduces Mast Cell Burden, Improves Symptoms, and Has a Favorable Safety Profile in Patients with Indolent Systemic Mastocytosis: Analysis of the Harbor Trial
Tsewang Tashi, Olivier Hermine, Mariana Castells, Mar Guilarte, Vito Sabato, Marcus Maurer, +26 more
19citations -
KIT D816V Mast Cells Derived from Induced Pluripotent Stem Cells Recapitulate Systemic Mastocytosis Transcriptional Profile2023 International Journal of Molecular Sciences article Immunology and Microbiology Mast cells and histamine Open access
Marcelo A. S. Toledo, Xu‐Huang Fu, Tiago Maié, Eva Miriam Buhl, Katrin Götz, Susanne Schmitz, +8 more
11citations -
Ultra-Sensitive SuperRCA Assay Enhances the Ability to Detect KIT D816V Mutations in Peripheral Blood With a Sensitivity Comparable to That of Bone Marrow Testing2026 Journal of Allergy and Clinical Immunology article Immunology and Microbiology Mast cells and histamine Open access
Frank Siebenhaar, Mariana Castells, Cristina Bulai Livideanu, Tsewang Tashi, Jens Panse, Vito Sabato, +17 more
0citations -
Anaphylaxis events in the PIONEER study of avapritinib in indolent systemic mastocytosis2026 World Allergy Organization Journal article Immunology and Microbiology Mast cells and histamine Open access
Thanai Pongdee, Mariana Castells, Cem Akin, Ingunn Dybedal, Jason R. Gotlib, Jens Peter Panse, +12 more
3citations -
Avapritinib improves cutaneous involvement in patients with indolent systemic mastocytosis: Results from the randomized, phase 2, interventional PIONEER study2026 Journal of the American Academy of Dermatology article Immunology and Microbiology Mast cells and histamine Open access
Frank Siebenhaar, Sigurd Broesby‐Olsen, Mariana Castells, Tracy I. George, Cristina Bulai Livideanu, Iván Álvarez‐Twöse, +25 more
7citations -
Capitalizing on paradoxical activation of the mitogen‐activated protein kinase pathway for treatment of Imatinib‐resistant mast cell leukemia2022 Hematological Oncology article Immunology and Microbiology Mast cells and histamine Open access
Thomas Wilhelm, Marcelo A. S. Toledo, Ilka Simons, Christian Stuth, Vrinda Mohta, Ronja Isabelle Mülfarth, +9 more
5citations -
Capitalizing on paradoxical activation of the MAPK pathway for treatment of Imatinib-resistant mast cell leukemia2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Immunology and Microbiology Mast cells and histamine Open access
Thomas Wilhelm, Marcelo A. S. Toledo, Ilka Simons, Christian Stuth, Vrinda Mohta, Ronja Isabelle Mülfarth, +7 more
0citations -
Avapritinib versus Placebo in Indolent Systemic Mastocytosis2023 NEJM Evidence article Immunology and Microbiology Mast cells and histamine Open access cited by 2 patents
Jason R. Gotlib, Mariana Castells, Hanneke Oude Elberink, Frank Siebenhaar, Karin Hartmann, Sigurd Broesby‐Olsen, +46 more
80citations