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Reduced-Dose Intravenous Thrombolysis for Acute Intermediate–High-risk Pulmonary Embolism: Rationale and Design of the Pulmonary Embolism International THrOmbolysis (PEITHO)-3 trial2021 Thrombosis and Haemostasis article Medicine Venous Thromboembolism Diagnosis and Management Open access
Olivier Sanchez, Anaïs Charles‐Nelson, Walter Ageno, Stefano Barco, Harald Binder, Gilles Châtellier, +22 more
145citations -
Rationale and design of the Renal Lifecycle trial assessing the effect of dapagliflozin on cardiorenal outcomes in severe chronic kidney disease2025 Nephrology Dialysis Transplantation article Medicine Chronic Kidney Disease and Diabetes Open access
Wisanne M. Bakker, Hiddo J.L. Heerspink, Stefan P. Berger, Christoph Wanner, Sunil V. Badve, Clare Gabrielle Arnott, +80 more
35citations -
Efficacy and Safety of Low-Dose Digoxin in Patients with Heart Failure. Rationale and Design of the DECISION Trial2024 European Journal of Heart Failure article Medicine Heart Failure Treatment and Management Open access
Dirk J. van Veldhuisen, Michiel Rienstra, Arend Mosterd, A. Marco Alings, Antoinette D. I. van Asselt, Marcel L. Bouvy, +15 more
33citations -
A sexual rehabilitation intervention for women with gynaecological cancer receiving radiotherapy (SPARC study): design of a multicentre randomized controlled trial
Isabelle Suvaal, Susanna B. Hummel, Jan-Willem M. Mens, Helena C. van Doorn, Wilbert B. van den Hout, Carien L. Creutzberg, +1 more
17citations -
Rationale and design of the OPTIMIZE trial: OPen label multicenter randomized trial comparing standard IMmunosuppression with tacrolimus and mycophenolate mofetil with a low exposure tacrolimus regimen In combination with everolimus in de novo renal transplantation in Elderly patients
Silke E. de Boer, Jan‐Stephan Sanders, Fréderike J. Bemelman, Michiel G.H. Betjes, Johannes G. M. Burgerhof, Luuk B. Hilbrands, +7 more
16citations -
Efficacy and safety of early target-controlled plasma volume replacement with a balanced gelatine solution versus a balanced electrolyte solution in patients with severe sepsis/septic shock: study protocol, design, and rationale of a prospective, randomized, controlled, double-blind, multicentric, international clinical trial
Gernot Marx, Kai D. Zacharowski, Carole Ichaï, Karim Asehnoune, Vladimír Černý, Rolf Dembinski, +11 more
15citations -
Study protocol: Effectiveness of dual-mobility cups compared with uni-polar cups for preventing dislocation after primary total hip arthroplasty in elderly patients — design of a randomized controlled trial nested in the Dutch Arthroplasty Registry
Loes W A H van Beers, Bart C. H. van der Wal, Tess Glastra van Loon, Dirk Jan F. Moojen, Marieke F. van Wier, Amanda D Klaassen, +2 more
15citations -
Effectiveness of intramuscular gluteal glucocorticoid injection versus intra-articular glucocorticoid injection in knee osteoarthritis: design of a multicenter randomized, 24 weeks comparative parallel-group trial2020 BMC Musculoskeletal Disorders article Medicine Osteoarthritis Treatment and Mechanisms Open access
Marianne F. Mol, J. Runhaar, P.K. Bos, Desirée M. J. Dorleijn, Marijn Vis, Jacobijn Gussekloo, +2 more
13citations -
Heart Team risk assessment with angiography‐derived fractional flow reserve determining the optimal revascularization strategy in patients with multivessel disease: Trial design and rationale for the DECISION QFR randomized trial
Kotaro Miyata, Taku Asano, Akira Saito, Kohei Abe, Toru Tanigaki, Masahiro Hoshino, +26 more
6citations -
bletl - A Python Package for Integrating Microbioreactors in the Design-Build-Test-Learn Cycle2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Microbial Metabolic Engineering and Bioproduction Open access
Michael Osthege, Niklas Tenhaef, Rebecca Zyla, Carolin Müller, Johannes Hemmerich, Wolfgang Wiechert, +2 more
3citations -
PO.6.137 Design of a phase 2, multicenter, randomized, placebo-controlled, parallel-group, double-blind study to assess the efficacy and safety of nipocalimab in adults with active systemic lupus erythematosus
Fang Liu-walsh, Bart van Hartingsveldt, Qing Zuraw, RW Hoffman, Terence P. Rooney, Sheng Gao, +6 more
0citations -
Design of VICTORION-2 Prevent: A randomized double-blind, placebo-controlled trial, assessing the impact of inclisiran on major adverse cardiovascular events in patients with established cardiovascular disease
Philippe Gabríel Steg, Shaun G. Goodman, J. Wouter Jukema, Pieter Martens, Andreas Zirlik, Deepak L. Bhatt, +9 more
6citations -
Rationale and study design of a trial to assess rTMS add-on value for the amelioration of negative symptoms of schizophrenia (RADOVAN)2022 Contemporary Clinical Trials Communications article Neuroscience Transcranial Magnetic Stimulation Studies Open access
Tobias Hebel, Berthold Langguth, Martin Schecklmann, Stefan Schoisswohl, Susanne Staudinger, Axel Schiller, +9 more
4citations -
Design of the VOILA-intervention study: A 12-week nutrition and resistance exercise intervention in metabolic or mobility compromised Dutch older adults and the response on immune-metabolic, gut and muscle health parameters2024 Mechanisms of Ageing and Development article Medicine Nutrition and Health in Aging Open access cited by 1 patent
Alejandra P. Monsegue, Jordi Morwani‐Mangnani, Pol Grootswagers, Marian Beekman, P. Eline Slagboom, Lex B. Verdijk, +1 more
4citations -
Virtual reality for psycho-education on self-stigma in depression: Design of a randomised controlled trial2022 Psychiatry Research Communications article Psychology Mental Health Treatment and Access Open access
Nancy Kramer Freher, Anika Bexkens, Martine van Bennekom, Wim Veling, Claudi Bockting
3citations -
Feeding practices during childhood illness and associated factors among mothers of children under 24 month olds in southwest Ethiopia: A Facility-based cross-sectional study design
Dawit Hailu, Vinod V. Bagilkar, Ebissa Bayana Kebede, Tesfaye Negash Asfaw, Merga Garoma Jatu, Assefa Desalew, +3 more
1citations -
TANGENT study design: a phase III, randomized study of emactuzumab for the treatment of tenosynovial giant cell tumors2026 Future Oncology article Medicine Musculoskeletal synovial abnormalities and treatments Open access
Hans A. J. Gelderblom, Emanuela Palmerini, Michiel A. J. van de Sande, Javier Martín‐Broto, Gabriel Tinoco, Elyse Seltzer, +4 more
0citations