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Rationale and design of a prospective, randomized, controlled, multicenter study to evaluate the safety and efficacy of transcatheter heart valve replacement in female patients with severe symptomatic aortic stenosis requiring aortic valve intervention (Randomized researcH in womEn all comers wIth Aortic stenosis [RHEIA] trial)
Hélène Eltchaninoff, Nikolaos E. Bonaros, Bernard Prendergast, Fabian Nietlispach, Mariuca Vasa‐Nicotera, Alaide Chieffo, +8 more
38citations -
Thrombectomy in high-risk pulmonary embolism – device versus thrombolysis: rationale and design of the TORPEDO-NL investigator-initiated, academically-sponsored, multicenter, open-label randomized controlled trial2025 Thrombosis Research article Medicine Venous Thromboembolism Diagnosis and Management Open access
Wilhelmina J.E. Stenger, Corstiaan A. den Uil, Wim J. R. Rietdijk, Ibtihal Al Amri, José M. Montero Cabezas, Thijs E. van Mens, +44 more
8citations -
Design and rationale of the prospective, randomized, controlled trial to assess the management of moderate aortic stenosis by clinical surveillance or transcatheter aortic valve replacement: The PROGRESS Trial
Philippe Généreux, Raj Makkar, Jeroen Joost Bax, Philippe Pîbarot, Brian R. Lindman, Brandon Park, +3 more
3citations -
Efficacy of LGE‐MRI‐guided fibrosis ablation versus conventional catheter ablation of atrial fibrillation: The DECAAF II trial: Study design2021 Journal of Cardiovascular Electrophysiology article Medicine Atrial Fibrillation Management and Outcomes
Nassir F. Marrouche, Tom Greene, J. Michael Dean, Eugene G. Kholmovski, Leonie Morrison-de Boer, MOUSSA C. MANSOUR, +12 more
90citations -
Less bleeding by omitting aspirin in non-ST-segment elevation acute coronary syndrome patients: Rationale and design of the LEGACY study2023 American Heart Journal article Medicine Antiplatelet Therapy and Cardiovascular Diseases Open access
Niels M R van der Sangen, I. Tarik Küçük, Shabiga Sivanesan, Yolande Appelman, Jurriën M. ten Berg, Ashley Verburg, +24 more
16citations -
A two arm randomized controlled trial comparing the short and long term effects of an elimination diet and a healthy diet in children with ADHD (TRACE study). Rationale, study design and methods
Annick Bosch, Margreet Bierens, G. Ardine de Wit, Verena Ly, Jessica van der Velde, Heleen de Boer, +16 more
12citations -
Left Atrial Appendage Occlusion Versus NOACs in patients With Atrial Fibrillation: Rationale and Design of the CATALYST Trial2026 American Heart Journal article Medicine Atrial Fibrillation Management and Outcomes Open access
Vivek Yerrapu Reddy, Elaine M. Hylek, Alan John Camm, Jonathan L. Halperin, Hans‐Christoph Diener, David Thaler, +10 more
12citations -
Care after pancreatic resection according to an algorithm for early detection and minimally invasive management of pancreatic fistula versus current practice (PORSCH-trial): design and rationale of a nationwide stepped-wedge cluster-randomized trial
F. Jasmijn Smits, Anne Claire Henry, Casper H.J. van Eijck, Marc G. Besselink, Olivier R. Busch, Mark J. Arntz, +25 more
45citations -
COMPARE LAAO: Rationale and design of the randomized controlled trial “COMPARing Effectiveness and safety of Left Atrial Appendage Occlusion to standard of care for atrial fibrillation patients at high stroke risk and ineligible to use oral anticoagulation therapy”2022 American Heart Journal article Medicine Atrial Fibrillation Management and Outcomes Open access
Marina Huijboom, Moniek Maarse, Errol W. Aarnink, Vincent F. van Dijk, Martin John Swaans, Sander Ijsselmuiden, +16 more
17citations -
Care after pancreatic resection according to an algorithm for early detection and minimally invasive management of pancreatic fistula versus current practice (PORSCH-trial): design and rationale of a nationwide stepped-wedge cluster randomized trial
F. Jasmijn Smits, AC Henry, CH van Eijck, Marc G. Besselink, O. R. C. Busch, M Arntz, +25 more
0citations -
The Use of a Pressure Vest to Reduce Anxiety and Dissociation during Eye Movement Desensitization and Reprocessing—A Single-Case Experimental Design Study2026 Journal of EMDR Practice and Research article Psychology Posttraumatic Stress Disorder Research Open access
E. Judith van de Blokenhoeve, Patrick Onghena, Julia F. van den Berg
0citations -
The MANGROVE Phase 2 Trial: Study Design and Baseline Characteristics of Patients With Autosomal Dominant Polycystic Kidney Disease2022 Journal of the American Society of Nephrology conference-abstract Biochemistry, Genetics and Molecular Biology Genetic and Kidney Cyst Diseases
Ron T. Gansevoort, Antonio Pisani, Miguel Hueso, Davinia Van den Bergh, Willem Hettema, Karine Muller, +2 more
1citations -
Personalized hemodynamic management targeting preoperative baseline cardiac index in high-risk patients having major abdominal surgery: rationale and design of the international multicenter randomized PELICAN trial
Moritz Flick, Eske Kvanner Aasvang, Michael Eichlseder, Adam Klimovic, Agnes Sophia Meidert, Christian Sylvest Meyhoff, +11 more
1citations -
Rationale and Design of GnG-Trial: A Randomized Phase-III Study to Compare Two Schedules of Gemtuzumab Ozogamicin as Adjunct to Intensive Induction Therapy and to Compare Double-Blinded Intensive Postremission Therapy with or Without Glasdegib in Older Patients with Newly Diagnosed AML
Sonia Jaramillo, Johannes Krisam, Lucian Le Cornet, Markus Kratzmann, Lukas Baumann, Tim Sauer, +28 more
0citations -
Personalized hemodynamic management targeting preoperative baseline cardiac index in high-risk patients having major abdominal surgery: rationale and design of the international multicenter randomized PELICAN trial
Moritz Flick, Eske Kvanner Aasvang, Michael Eichlseder, Adam Klimovic, Agnes Sophia Meidert, Christian Sylvest Meyhoff, +11 more
0citations -
Design and rationale of the RISC-trial: multicentre R CT to assess i mmediate discharge of s yncope patients admitted to the ( c ardiac) emergency room2026 European Heart Journal Open article Medicine Cardiovascular Syncope and Autonomic Disorders Open access
Thomas T. Boel, Suzanne Peeters, Anouk P. van Alem, Mark J. Boogers, Marianne Bootsma, Marinus A. van den Dorpel, +23 more
0citations -
Personalized hemodynamic management targeting preoperative baseline cardiac index in high-risk patients having major abdominal surgery: rationale and design of the international multicenter randomized PELICAN trial
Moritz Flick, Eske Kvanner Aasvang, Michael Eichlseder, Adam Klimovic, Agnes Sophia Meidert, Christian Sylvest Meyhoff, +11 more
0citations