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Efficacy and safety of early target-controlled plasma volume replacement with a balanced gelatine solution versus a balanced electrolyte solution in patients with severe sepsis/septic shock: study protocol, design, and rationale of a prospective, randomized, controlled, double-blind, multicentric, international clinical trial
Gernot Marx, Kai D. Zacharowski, Carole Ichaï, Karim Asehnoune, Vladimír Černý, Rolf Dembinski, +11 more
15citations -
Adding eptinezumab to brief patient education to treat chronic migraine and medication-overuse headache: Protocol for RESOLUTION—A phase 4, multinational, randomized, double-blind, placebo-controlled study
Rigmor Jensen, Henrik Winther Schytz, Cristina Tassorelli, Gisela Marie Terwindt, Louise Ninett Carlsen, Aurélia Mittoux, +5 more
15citations -
A randomized, double-blind, placebo-controlled 12-week trial of infliximab in patients with juvenile-onset spondyloarthritis2022 Arthritis Research & Therapy article Medicine Spondyloarthritis Studies and Treatments Open access
Rubén Burgos‐Vargas, Adalberto Loyola Sánchez, Sofía Ramiro, Arturo Reding‐Bernal, Everardo Alvarez Hernández, Désirée M F M van der Heijde, +1 more
14citations -
Vericiguat: A Randomized, Phase Ib, Placebo-Controlled, Double-Blind, QTc Interval Study in Patients with Chronic Coronary Syndromes2023 American Journal of Cardiovascular Drugs article Medicine Heart Failure Treatment and Management Open access
M. Böttcher, Hans‐Dirk Düngen, Vasile Corcea, Frank Donath, Rainard Fuhr, Pim Gal, +8 more
14citations -
#3848 ORIGIN TRIAL: 24-WK PRIMARY ANALYSIS OF A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PH2B STUDY OF ATACICEPT IN PATIENTS WITH IGAN2023 Nephrology Dialysis Transplantation article Medicine Renal Diseases and Glomerulopathies Open access
Richard A. Lafayette, Bart Maes, Celia J. F. Lin, Sean J. Barbour, Richard K. S. Phoon, Sung Gyun Kim, +4 more
14citations -
TOTUM ‐63, a plant‐based polyphenol‐rich extract, improves glycaemic control in subjects with prediabetes or early stage newly‐diagnosed type 2 diabetes in a randomized, double‐blind, placebo‐controlled trial2022 Diabetes Obesity and Metabolism article Medicine Natural Antidiabetic Agents Studies Open access
Pascal Sirvent, Vivien Chavanelle, Yolanda F. Otero, Maxime Bargetto, Florian Le Joubioux, Nathalie Boisseau, +7 more
13citations -
The effects of polyunsaturated fatty acid (PUFA) administration on the microbiome-gut-brain axis in adolescents with anorexia nervosa (the MiGBAN study): study protocol for a longitudinal, double-blind, randomized, placebo-controlled trial
Lara Keller, Astrid Dempfle, Brigitte Dahmen, Samira Schreiber, Roger A.H. Adan, Nadia Andrea Andreani, +14 more
13citations -
PragmaTic, prospEctive, randomized, controlled, double-blind, mulTi-centre, multinational study on the safety and efficacy of a 6% HydroxYethyl Starch (HES) solution versus an electrolyte solution in trauma patients: study protocol for the TETHYS study
Clementina Duran Palma, Musawenkosi Mamba, Johan Geldenhuys, Oluwafolajimi Fadahun, Rolf Rossaint, Kai D. Zacharowski, +10 more
12citations -
Adaptogenic Ashwagandha root extract modulates inflammatory markers in feline stress management: a double-blind placebo-controlled clinical trial2024 Journal of Applied Animal Research article Medicine Phytochemicals and Medicinal Plants Open access
Ashok Kumar Devarasetti, Kala Kumar Bharani, Amit Khurana, Sunil Anand, Rajesh Kollipaka, Venkata Dharma Teja Saranu, +4 more
10citations -
Efficacy and safety of ivermectin for the treatment of Plasmodium falciparum infections in asymptomatic male and female Gabonese adults – a pilot randomized, double-blind, placebo-controlled single-centre phase Ib/IIa clinical trial
Dorothea Ekoka Mbassi, Ghyslain Mombo‐Ngoma, Jana Held, Dearie Glory Okwu, Wilfrid Ndzebe Ndoumba, Laura C Kalkman, +11 more
10citations -
Study protocol: DexaDays-2, hydrocortisone for treatment of dexamethasone-induced neurobehavioral side effects in pediatric leukemia patients: a double-blind placebo controlled randomized intervention study with cross-over design
Annelienke M. van Hulst, Emma J. Verwaaijen, Marta F. Fiocco, Saskia M.F. Pluijm, Martha Alexandra Grootenhuis, Rob Pieters, +2 more
10citations -
Study protocol of the multicentre, randomised, triple-blind, placebo-controlled MERCURI-2 trial: promoting effective renoprotection in cardiac surgery patients by inhibition of sodium glucose cotransporter (SGLT)-2
Maartina J P Oosterom-Eijmael, Ed D Niesten, Martijn Tolsma, Ferdinand T. Snellen, Bas M. Gerritse, Thierry V. Scohy, +10 more
10citations -
Editor's Choice – Activated Clotting Time Guided Heparinisation during Open Abdominal Aortic Aneurysm Repair (ACTION-1): A Randomised, Multicentre, Single Blind, Superiority Trial2025 European Journal of Vascular and Endovascular Surgery article Medicine Aortic aneurysm repair treatments Open access
Vincent Jongkind, Thomas A H Steunenberg, Liliane C. Roosendaal, Max Hoebink, Jan D. Blankensteijn, Mark J.W. Koelemay, +16 more
10citations -
Hydrocortisone to reduce dexamethasone-induced neurobehavioral side-effects in children with acute lymphoblastic leukaemia—results of a double-blind, randomised controlled trial with cross-over design
Annelienke M. van Hulst, Erica L T van den Akker, Emma J. Verwaaijen, Marta F. Fiocco, Niki Rensen, Raphaële R. L. van Litsenburg, +7 more
10citations -
Does paracetamol improve quality of life, discomfort, pain and neuropsychiatric symptoms in persons with advanced dementia living in long-term care facilities? A randomised double-blind placebo-controlled crossover (Q-PID) trial
Paulien H. van Dam, Wilco P. Achterberg, Bettina Sandgathe Husebo, Monique A. A. Caljouw
10citations -
IMI2-PainCare-BioPain-RCT2 protocol: a randomized, double-blind, placebo-controlled, crossover, multicenter trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity
Caterina Maria Leone, Giulia Di Stefano, Giuseppe Di Pietro, Petra Bloms‐Funke, Irmgard Boesl, Ombretta Caspani, +22 more
10citations -
Inhibition of structural damage progression with the selective interleukin-23 inhibitor guselkumab in participants with active PsA: results through week 24 of the phase 3b, randomised, double-blind, placebo-controlled APEX study2025 Annals of the Rheumatic Diseases article Medicine Spondyloarthritis Studies and Treatments Open access
Philip J. Mease, Christopher T. Ritchlin, Laura C. Coates, Alexa P. Kollmeier, Bei Zhou, Yusang Jiang, +6 more
10citations -
Adalimumab combined with methotrexate versus adalimumab monotherapy in psoriasis: Three‐year follow‐up data of a single‐blind randomized controlled trial2023 Journal of the European Academy of Dermatology and Venereology article Immunology and Microbiology Psoriasis: Treatment and Pathogenesis Open access
Astrid M. van Huizen, Gayle E. van der Kraaij, Celine I. Busard, Wouter Ouwerkerk, Juul M. P. A. van den Reek, Stef P. Menting, +7 more
9citations -
Safety, reactogenicity and immunogenicity of an intranasal seasonal influenza vaccine adjuvanted with gram-positive matrix (GEM) particles (FluGEM): A randomized, double-blind, controlled, ascending dose study in healthy adults and elderly
Johan L. van der Plas, Bert Jan Haijema, Kees J. Leenhouts, J. Paul Zoeteweij, Jacobus Burggraaf, Ingrid M. C. Kamerling
9citations -
Safety, Pharmacokinetics, and Pharmacodynamics of a 6‐h N , N ‐Dimethyltryptamine (DMT) Infusion in Healthy Volunteers: A Randomized, Double‐Blind, Placebo‐Controlled Trial2025 Clinical and Translational Science article Psychology Psychedelics and Drug Studies Open access
Katelijne V. van der Heijden, Rob G. J. A. Zuiker, Marije E. Otto, Christopher F. Bryan, Marieke L. de Kam, Marloes B. van Leuken, +2 more
9citations -
Virtual-reality cognitive behavior therapy versus cognitive behavior therapy for paranoid ideation: A pragmatic, single-blind, multicenter randomized clinical superiority trial
Chris Neeltje Wil Geraets, Maureen Berkhof, Marit Hidding, Sven van Amstel, David P. G. van den Berg, Rob van Grunsven, +6 more
8citations