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Arthroscopic synovectomy versus intra-articular injection of corticosteroids for the management of refractory psoriatic or rheumatoid arthritis of the wrist: study protocol for a randomized controlled trial (ARCTIC trial)
Philip N. d'Ailly, C. Deugd, N.W.L. Schep, Tjallingius Martijn Kuijper, Marc R. Kok, Annemiek Willemze, +7 more
8citations -
Study protocol of a randomized, double-blind, placebo-controlled, multi-center trial to treat antipsychotic-induced weight gain: the Metformin-Lifestyle in antipsychotic users (MELIA) trial
Nini de Boer, Sinan Gülöksüz, Caroline G. C. M. van Baal, Leonie Willebrands, Jeroen Deenik, Christiaan H. Vinkers, +18 more
5citations -
Adding eltrombopag to immunosuppressive treatment with cyclosporine as front-line therapy for moderate aplastic anemia improves trilineage hematologic response: One-year analysis of the randomised, placebo-controlled, double-blind Phase III trial eltrombopag for moderate aplastic anemia (EMAA Trial)2025 Blood conference-abstract Biochemistry, Genetics and Molecular Biology Blood disorders and treatments Open access
Britta Hoechsmann, Philippe Schafhausen, Fabian Beier, Michael Heuser, Joerg Westermann, Beatrice Drexler, +10 more
0citations -
Randomized Controlled Trial Comparing Drug-coated Balloon Angioplasty versus Conventional Balloon Angioplasty for Treating Below-the-Knee Arteries in Critical Limb Ischemia: The SINGA-PACLI Trial
Ankur K. Patel, Farah Gillan Irani, Uei Pua, Kiang Hiong Tay, Tze Tec Chong, Sum Leong, +12 more
43citations -
Long-term results of the NECK trial—implanting a disc prosthesis after cervical anterior discectomy cannot prevent adjacent segment disease: five-year clinical follow-up of a double-blinded randomised controlled trial
Caroline M.W. Goedmakers, Floor E. de Vries, Lisette Bosscher, Wilco C. Peul, Mark P. Arts, Carmen L. A. Vleggeert-Lankamp
26citations -
Randomized phase III trial of induction chemotherapy followed by chemoradiotherapy or chemotherapy alone for nonresectable locally advanced pancreatic cancer: First results of the CONKO-007 trial.2022 Journal of Clinical Oncology conference-abstract Medicine Pancreatic and Hepatic Oncology Research
Rainer J. Fietkau, Michael B. Ghadimi, Robert Grützmann, Uwe A. Wittel, Lutz Jacobasch, Waldemar Uhl, +14 more
118citations -
Prospective randomized multicenter phase III trial comparing perioperative chemotherapy (FLOT protocol) to neoadjuvant chemoradiation (CROSS protocol) in patients with adenocarcinoma of the esophagus (ESOPEC trial).2024 Journal of Clinical Oncology conference-abstract Medicine Esophageal Cancer Research and Treatment Open access
Jens Hoeppner, Thomas Baptist Brunner, Florian Lordick, Claudia Schmoor, Birte Kulemann, Ulf P. Neumann, +14 more
99citations -
Rationale and design of the OPTIMIZE trial: OPen label multicenter randomized trial comparing standard IMmunosuppression with tacrolimus and mycophenolate mofetil with a low exposure tacrolimus regimen In combination with everolimus in de novo renal transplantation in Elderly patients
Silke E. de Boer, Jan‐Stephan Sanders, Fréderike J. Bemelman, Michiel G.H. Betjes, Johannes G. M. Burgerhof, Luuk B. Hilbrands, +7 more
16citations -
Randomised Clinical Trial to Evaluate the Efficacy of Acetazolamide for the Treatment of Cystoid Fluid Collections in X‐Linked Retinoschisis: The AXIS Trial2026 Clinical and Experimental Ophthalmology article Biochemistry, Genetics and Molecular Biology Retinal Development and Disorders Open access
Jonathan Hensman, Hind Almushattat, Roselie M.H. Diederen, Tien‐En Tan, Peilun Dai, Coen de Vente, +10 more
2citations -
Long‐term follow‐up of chronic central serous chorioretinopathy patients receiving oral eplerenone and half‐dose photodynamic therapy in the SPECTRA trial: SPECTRA trial report No. 4
Helena M. A. Feenstra, Issam el Mansori, Thomas J. van Rijssen, Roula Tsonaka, Roselie M.H. Diederen, Carel B. Hoyng, +3 more
0citations -
Trial in Progress: A Randomized-Controlled Phase 2 Study Evaluating Venetoclax Plus Azacitidine Versus Intensive Chemotherapy in Adult Patients with Newly Diagnosed, NPM1-Mutated AML - the SAL/AMLCG Vincent Trial
Leo Ruhnke, Christoph Schliemann, Lars R. Fransecky, Björn Steffen, Martin Kaufmann, Andreas Burchert, +26 more
2citations -
796. P02.05 NEOADJUVANT CHEMORADIOTHERAPY FOLLOWED BY ACTIVE SURVEILLANCE VERSUS STANDARD SURGERY FOR OESOPHAGEAL CANCER (SANO-TRIAL): A MULTICENTRE STEPPED-WEDGE CLUSTER-RANDOMISED NONINFERIORITY TRIAL
Berend J. van der Wilk, Ben M. Eyck, Bas P. L. Wijnhoven, Sjoerd M. Lagarde, Camiel Rosman, Bo Jan Noordman, +28 more
1citations -
RIFAMPICIN COMBINATION THERAPY VERSUS TARGETED ANTIMICROBIAL MONOTHERAPY IN THE ORAL ANTIMICROBIAL TREATMENT PHASE OF STAPHYLOCOCCAL PROSTHETIC JOINT INFECTION (RICOTTA-TRIAL): PROTOCOL FOR A RANDOMIZED, CONTROLLED, OPEN-LABEL, NON-INFERIORITY TRIAL
Jaap L.J. Hanssen, Karin M. Veerman, Olav van der Jagt, Matthijs Paul Somford, Jolanda Lammers, Rudolf Wilhelm Poolman, +12 more
2citations -
The NADINA trial: A multicenter, randomised, phase 3 trial comparing the efficacy of neoadjuvant ipilimumab plus nivolumab with standard adjuvant nivolumab in macroscopic resectable stage III melanoma.2022 Journal of Clinical Oncology conference-abstract Medicine Cutaneous Melanoma Detection and Management
Minke W. Lucas, J. Lijnsvelt, Saskia M. Pulleman, Richard A. Scolyer, Alexander Maxwell Menzies, Alexander C. J. van Akkooi, +13 more
47citations -
An exploratory open-label multicentre phase I/II trial evaluating the safety and efficacy of postnatal or prenatal and postnatal administration of allogeneic expanded fetal mesenchymal stem cells for the treatment of severe osteogenesis imperfecta in infants and fetuses: the BOOSTB4 trial protocol2024 BMJ Open article Biochemistry, Genetics and Molecular Biology Connective tissue disorders research Open access
Eva Åström, Lyn S. Chitty, Belinda Crowe, Anna Louise David, Catherine J DeVile, Annabelle Forsmark, +17 more
25citations -
An adaptive phase II/III safety and efficacy randomized controlled trial of single day or three-day fixed-dose albendazole-ivermectin co-formulation versus albendazole for the treatment of Trichuris trichiura and other STH infections. ALIVE trial protocol2022 Gates Open Research article Immunology and Microbiology Parasites and Host Interactions Open access
Alejandro Javier Krolewiecki, Wendemagegn Enbiale, Javier Gandasegui, Lisette van Lieshout, Stella Kepha, Augusto Messa, +15 more
16citations -
Physiological-based cord clamping in very preterm infants: the Aeration, Breathing, Clamping 3 (ABC3) trial—statistical analysis plan for a multicenter randomized controlled trial
Sten Paul Willemsen, Ronny Knol, Emma Brouwer, Thomas van den Akker, Philip L J DeKoninck, Enrico Lopriore, +14 more
4citations -
Peer Review Report For: An adaptive phase II/III safety and efficacy randomized controlled trial of single day or three-day fixed-dose albendazole-ivermectin co-formulation versus albendazole for the treatment of Trichuris trichiura and other STH infections. ALIVE trial protocol [version 1; peer review: 2 approved]
Alejandro Krolewiecki, Wendemagegn Enbiale, Javier Gandasegui, Lisette van Lieshout, Stella Kepha, Augusto Messa, +15 more
0citations -
Peer Review Report For: An adaptive phase II/III safety and efficacy randomized controlled trial of single day or three-day fixed-dose albendazole-ivermectin co-formulation versus albendazole for the treatment of Trichuris trichiura and other STH infections. ALIVE trial protocol [version 1; peer review: 2 approved]
Alejandro Krolewiecki, Wendemagegn Enbiale, Javier Gandasegui, Lisette van Lieshout, Stella Kepha, Augusto Messa, +15 more
0citations