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External validation of a prognostic model predicting renal graft function one year after brain-dead donor kidney transplantation2026 Langenbeck s Archives of Surgery article Medicine Renal Transplantation Outcomes and Treatments Open access
Philipp Tessmer, Clara A. Weigle, F. Meister, Bengt Arne Wiemann, Wilfried Gwinner, Anja M€uhlfeld, +8 more
0citations -
Translational Application of the Five-Star Matrix for the Structure-Guided Optimization of a Bicyclopiperazine DEL Hit into Bcpz 1.5: A Potent Monoacylglycerol Lipase Inhibitor with Functional Inhibition in Human Brain Homogenate and Efficacy in Neuroinflammatory Models
Benjamin Brennecke, Louise Plais, Benoit Hornsperger, Martin Binder, Christian Bartelmus, Markus Bürkler, +32 more
0citations -
Altered protein expression of membrane transporters in isolated cerebral microvessels and brain cortex of a rat Alzheimer's disease model2022 Neurobiology of Disease article Medicine Alzheimer's disease research and treatments Open access
Elena Puris, Seppo O. K. Auriola, Sabrina Petralla, Robin J. G. Hartman, Mikko Gynther, Elizabeth C. M. de Lange, +1 more
32citations -
Does poor methodological quality of prediction modeling studies translate to poor model performance? An illustration in traumatic brain injury2022 Diagnostic and Prognostic Research article Decision Sciences Meta-analysis and systematic reviews Open access
Isabel Retel Helmrich, Ana Mikolić, David M. Kent, Hester Floor Lingsma, Laure Wynants, Ewout Willem Steyerberg, +1 more
16citations -
The Extension of the LeiCNS-PK3.0 Model in Combination with the “Handshake” Approach to Understand Brain Tumor Pathophysiology2022 Pharmaceutical Research article Neuroscience Barrier Structure and Function Studies Open access
Makoto Hirasawa, Mohammed A. A. Saleh, Elizabeth C. M. de Lange
7citations -
RGD-coated polymeric microbubbles promote ultrasound-mediated drug delivery in an inflamed endothelium-pericyte co-culture model of the blood-brain barrier2024 Drug Delivery and Translational Research article Engineering Ultrasound and Hyperthermia Applications Open access
Christopher Hark, Junlin Chen, Eva Miriam Buhl, Harald Radermacher, Robert Pola, Michal Pechar, +7 more
8citations -
Targeted donor complement blockade after brain death prevents delayed graft function in a nonhuman primate model of kidney transplantation2020 American Journal of Transplantation article Medicine Renal Transplantation Outcomes and Treatments Open access cited by 1 patent
Juan Sebastian Danobeitia, Tiffany J. Zens, Peter J. Chlebeck, Laura Jo Zitur, José Antonio Muñoz Reyes, Michael J. Eerhart, +16 more
31citations -
Gut Microbiota and Brain Alterations after Refeeding in a Translational Anorexia Nervosa Rat Model2023 International Journal of Molecular Sciences article Biochemistry, Genetics and Molecular Biology Gut microbiota and health Open access
Stefanie Trinh, Vanessa Kogel, Lilly Kneisel, Elena Müller-Limberger, Beate Herpertz‐Dahlmann, Cordian Beyer, +1 more
16citations -
Drug Distribution in Brain and Cerebrospinal Fluids in Relation to IC50 Values in Aging and Alzheimer’s Disease, Using the Physiologically Based LeiCNS-PK3.0 Model2022 Pharmaceutical Research article Medicine Cholinesterase and Neurodegenerative Diseases Open access
Mohammed A. A. Saleh, Julia S. Bloemberg, Jeroen Elassaiss‐Schaap, Elizabeth C. M. de Lange
8citations -
Normothermic Machine Perfusion in a Porcine Donation After Brain Death Autotransplantation Model with the Fully Synthetic Perfusate Omnisol: A Feasibility Study2026 American Journal of Transplantation article Medicine Organ Transplantation Techniques and Outcomes
L. Ernst, A. Zare, W. Liu, J. Knorr, Christian Bleilevens, Oliver Beetz, +7 more
0citations -
Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice2023 Pharmaceutical Research article Neuroscience Barrier Structure and Function Studies Open access
Mohammed A. A. Saleh, Berfin Gülave, Olivia Campagne, Clinton F. Stewart, Jeroen Elassaiss‐Schaap, Elizabeth C. M. de Lange
5citations -
Normative modelling of brain morphometry across the lifespan with CentileBrain: algorithm benchmarking and model optimisation2024 The Lancet Digital Health article Neuroscience Functional Brain Connectivity Studies Open access
Ruiyang Ge, Yuetong Yu, Yi Xuan Qi, Yunan Vera Fan, Shiyu Chen, Chuntong Gao, +38 more
118citations -
Ensemble graph neural network model for classification of major depressive disorder using whole-brain functional connectivity2023 Frontiers in Psychiatry article Neuroscience Functional Brain Connectivity Studies Open access cited by 1 patent
Sujitha Venkatapathy, Mikhail Votinov, Lisa Wagels, SangYun Kim, Munseob Lee, Ute Habel, +2 more
44citations -
Do Brain Extracellular Fluid Concentrations Predict PET ‐Inferred Receptor Occupancy in Human CNS ? A Mechanistic Model‐Based Analysis of Dopamine D2 Receptor Ligands2026 Clinical Pharmacology & Therapeutics article Neuroscience Neurotransmitter Receptor Influence on Behavior Open access
Divakar Budda, J. G. Coen van Hasselt, Elizabeth C. M. de Lange
0citations -
Prediction of the Extent of Blood–Brain Barrier Transport Using Machine Learning and Integration into the LeiCNS-PK3.0 Model2025 Pharmaceutical Research article Computer Science Computational Drug Discovery Methods Open access
Berfin Gülave, Helle W. van den Maagdenberg, Luke van Boven, Gerard J. P. van Westen, Elizabeth C. M. de Lange, J. G. Coen van Hasselt
8citations -
Multimodal imaging of hair follicle bulge-derived stem cells in a mouse model of traumatic brain injury2020 Cell and Tissue Research article Medicine Traumatic Brain Injury and Neurovascular Disturbances Open access
Timo Schomann, Juvita Delancy Iljas, Ivo Que, Yuedan Li, Ernst Suidgeest, Luis Javier Cruz, +5 more
4citations