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CIP2A interacts with TopBP1 and is selectively essential for DNA damage-induced basal-like breast cancer tumorigenesis2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access
Anni Laine, Srikar Goud Nagelli, Caroline C. Farrington, Umar Butt, Anna N. Cvrljevic, Julia P. Vainonen, +17 more
2citations -
Finding novel vulnerabilities of hypomorphic BRCA1 alleles2026 Molecular Oncology article Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Gois, Rosalie A. Kampen, Marta San Martín Alonso, +5 more
0citations -
Finding novel vulnerabilities of hypomorphic BRCA1 alleles2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Anne Schreuder, Klaas de Lint, Mariana M. Gois, Rosalie A. Kampen, Marta San Martín Alonso, Ilse Nootenboom, +3 more
0citations -
Advancements in PARP1 Targeted Nuclear Imaging and Theranostic Probes2020 Journal of Clinical Medicine article Medicine Radiopharmaceutical Chemistry and Applications Open access
Ramya Ambur Sankaranarayanan, Susanne Kossatz, Wolfgang Weber, Mohsen Beheshti, Agnieszka Morgenroth, Felix Manuel Mottaghy
42citations -
A RAD51 functional assay as a candidate test for homologous recombination deficiency in ovarian cancer2023 Gynecologic Oncology article Medicine PARP inhibition in cancer therapy Open access cited by 1 patent
Félix Blanc‐Durand, Elisa Yaniz‐Galende, Alba Llop‐Guevara, Catherine Genestie, Violeta Serra, Andrea Herencia-Ropero, +18 more
31citations -
Targeting homologous recombination deficiency with intensified chemotherapy versus standard chemotherapy followed by olaparib in stage III breast cancer (SUBITO): an open-label, randomised, controlled, phase 3 trial
Rianne L Seefat, Sonja B. Vliek, Vincent M. T. de Jong, Sara Balduzzi, Ingrid A.M. Mandjes, Valesca P. Retèl, +39 more
2citations -
Post(neo)adjuvante Therapiekonzepte – Möglichkeiten der Therapieoptimierung2022 Der Gynäkologe article Biochemistry, Genetics and Molecular Biology Breast Cancer Treatment Studies
Natalia Krawczyk, Tanja Natascha Fehm, Elmar Stickeler, Christoph Thomssen, Marc Thill, Maggie Banys‐Paluchowski
0citations -
#384 First interim analysis of the SCOUT-1 Study (NOGGO Ov54, NCT04830709): a non-interventional study to evaluate treatment patterns and longterm outcome in patients with newly diagnosed advances ovarian cancer2023 International Journal of Gynecological Cancer article Medicine Ovarian cancer diagnosis and treatment Open access
Klaus Pietzner, Elena Ioana Braicu, Pauline Wimberger, Jessika Goldmann, Karol Kubiak, Nikolaus de Gregorio, +13 more
0citations -
469 Survey on the usage of PARP-inhibitor therapy in Germany – a national NOGGO/JAGO-AGO intergroup study2021 International Journal of Gynecological Cancer article Medicine PARP inhibition in cancer therapy Open access
Bich Doan Nguyen-Sträuli, P Meyer-Wilmes, Joanna Baum, A Kreklau, Christina Buschmann, S Boz, +6 more
0citations -
Komorbiditäten bei Patientinnen mit neu diagnostiziertem fortgeschrittenem Eierstockkrebs – Ergebnisse der 2. Zwischenanalyse der nicht-interventionellen SCOUT-1 Studie (NOGGO ov54, NCT04830709)
J. Goldmann, Pauline Wimberger, Th. Arndt, Klaus Pietzner, Karol Kubiak, Nikolaus de Gregorio, +14 more
0citations -
Minigene‐based splicing analysis and ACMG / AMP ‐based tentative classification of 56 ATM variants2022 The Journal of Pathology article Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Elena Bueno Martínez, Lara Sanoguera‐Miralles, Alberto Valenzuela‐Palomo, Ada Esteban‐Sánchez, Víctor Lorca, Inés Llinares‐Burguet, +9 more
23citations -
Pathology of Tumors Associated With Pathogenic Germline Variants in 9 Breast Cancer Susceptibility Genes2022 JAMA Oncology article Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Nasim Mavaddat, Leila Dorling, Jamie Allen, Anna González‐Neira, Renske Keeman, Manjeet K. Bolla, +85 more
171citations -
Breast cancer risks associated with missense variants in breast cancer susceptibility genes2022 Genome Medicine article Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Leila Dorling, Sara Carvalho, Jamie Allen, Michael T. Parsons, Cristina Fortuño, Anna González‐Neira, +90 more
60citations -
Alternative mRNA splicing can attenuate the pathogenicity of presumed loss-of-function variants in BRCA22020 Genetics in Medicine article Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Romy L.S. Mesman, Fabienne M.G.R. Calléja, Miguel de la Hoya, Peter Devilee, Christi J. van Asperen, Harry Vrieling, +1 more
40citations -
Risks of breast and ovarian cancer for women harboring pathogenic missense variants in BRCA1 and BRCA2 compared with those harboring protein truncating variants2021 Genetics in Medicine article Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Hongyan Li, Christoph Engel, Miguel de la Hoya, Paolo Peterlongo, Drakoulis Yannoukakos, Luca Livraghi, +55 more
32citations -
The impact of coding germline variants on contralateral breast cancer risk and survival2023 The American Journal of Human Genetics article Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Anna Morra, Nasim Mavaddat, Taru Muranen, Thomas U. Ahearn, Jamie Allen, Irene Louise Andrulis, +90 more
28citations -
Splicing predictions, minigene analyses, and ACMG ‐ AMP clinical classification of 42 germline PALB2 splice‐site variants2021 The Journal of Pathology article Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Alberto Valenzuela‐Palomo, Elena Bueno Martínez, Lara Sanoguera‐Miralles, Víctor Lorca, Eugenia Fraile‐Bethencourt, Ada Esteban‐Sánchez, +10 more
24citations -
RAD51D Aberrant Splicing in Breast Cancer: Identification of Splicing Regulatory Elements and Minigene-Based Evaluation of 53 DNA Variants2021 Cancers article Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Elena Bueno Martínez, Lara Sanoguera‐Miralles, Alberto Valenzuela‐Palomo, Víctor Lorca, Alicia Gómez-Sanz, Jamie Allen, +8 more
22citations -
FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women2023 European Journal of Human Genetics article Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Gisella Figlioli, Amandine Billaud, Thomas U. Ahearn, Natalia Antonenkova, Heiko Becher, Matthias W. Beckmann, +91 more
15citations -
A missense variant effect map for the human tumor-suppressor protein CHK22024 The American Journal of Human Genetics article Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Marinella Gebbia, Daniel Zimmerman, Rosanna Jiang, Maria H. T. Nguyen, Jochen Weile, Roujia Li, +12 more
14citations -
Uncovering the Contribution of Moderate-Penetrance Susceptibility Genes to Breast Cancer by Whole-Exome Sequencing and Targeted Enrichment Sequencing of Candidate Genes in Women of European Ancestry2022 Cancers article Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Martine Dumont, Nana Weber‐Lassalle, Charles Joly-Beauparlant, Corinna Ernst, Arnaud Droit, Bing Feng, +69 more
6citations