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Breast cancer genomes from CHEK2 c.1100delC mutation carriers lack somatic TP53 mutations and display a unique structural variant size distribution profile2023 Breast Cancer Research article Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Marcel Smid, Marjanka K. Schmidt, Wendy J. C. Prager‐van der Smissen, Kirsten Ruigrok-Ritstier, Maartje A. C. Schreurs, Sten Cornelissen, +8 more
10citations -
Multiple Mutations—A Genetic Marker for Extracapsular Spread in Human Papillomavirus/p16‐Positive Oropharyngeal Carcinoma2025 Laryngoscope Investigative Otolaryngology article Medicine Head and Neck Cancer Studies Open access
Raphaela Graessle, Iris Piwonski, Cora C. Husemann, Karsten Kleo, Deema Sabtan, Achim M. Franzen, +4 more
2citations -
Activating mutations in JAK2 and CALR differentially affect intracellular calcium flux in store operated calcium entry2024 Cell Communication and Signaling article Medicine Myeloproliferative Neoplasms: Diagnosis and Treatment Open access
Vikas Bhuria, Tobias J. Franz, Conny K. Baldauf, Martin Böttcher, Nicolas Chatain, Steffen Koschmieder, +5 more
18citations -
Generation and initial characterization of novel tumour organoid models to study human pancreatic cancer‐induced cachexia2020 Journal of Cachexia Sarcopenia and Muscle article Medicine Nutrition and Health in Aging Open access
Rianne D.W. Vaes, David P.J. van Dijk, Tessa T.J. Welbers, Marinus J. Blok, Merel R. Aberle, Lara Rosaline Heij, +3 more
48citations -
DrugEx v2: de novo design of drug molecules by Pareto-based multi-objective reinforcement learning in polypharmacology2021 Journal of Cheminformatics article Computer Science Computational Drug Discovery Methods Open access cited by 1 patent
Xuhan Liu, Kai Ye, Herman van Vlijmen, Michael Emmerich, Adriaan P. IJzerman, Gerard J. P. van Westen
118citations -
Sequential implementation of DSC-MR perfusion and dynamic [18F]FET PET allows efficient differentiation of glioma progression from treatment-related changes2020 European Journal of Nuclear Medicine and Molecular Imaging article Medicine Glioma Diagnosis and Treatment Open access
Eike Steidl, Karl‐Josef Langen, Sarah Abu Hmeidan, Nenad Polomac, Christian Filß, Norbert Galldiks, +8 more
57citations -
Intra-Tumoral Genomic Heterogeneity in Rectal Cancer: Mutational Status Is Dependent on Preoperative Biopsy Depth and Location2021 Cancers article Biochemistry, Genetics and Molecular Biology Cancer Genomics and Diagnostics Open access
Floris A. Vuijk, Carlijn van de Water, Shannon van Vliet, Maxime J.M. van der Valk, Femke Simmer, Cornelis J.�H. van de Velde, +3 more
6citations -
Validation of myeloproliferative neoplasms associated risk factor RDW as predictor of thromboembolic complications in healthy individuals: analysis on 6849 participants of the SHIP-study
Kirsi Marjaana Manz, Jeanette Bahr, Till Ittermann, Konstanze Döhner, Steffen Koschmieder, Tim H. Brümmendorf, +4 more
5citations -
Abnormal aortic hemodynamics are associated with risk factors for aortic complications in patients with marfan syndrome2022 IJC Heart & Vasculature article Biochemistry, Genetics and Molecular Biology Connective tissue disorders research Open access
Pim van Ooij, Vivian de Waard, Lukas M. Gottwald, Roland R.J. van Kimmenade, Arthur J.H.A. Scholte, Michael G. Dickinson, +4 more
7citations -
Artificial Intelligence–based Detection of FGFR3 Mutational Status Directly from Routine Histology in Bladder Cancer: A Possible Preselection for Molecular Testing?2021 European Urology Focus article Computer Science AI in cancer detection Open access cited by 1 patent
Chiara Maria Lavinia Loeffler, Nadina Ortiz Bruechle, Max Jung, Lancelot Seillier, Michael Rose, Narmin Ghaffari Laleh, +5 more
90citations -
Multicenter Comparison of Molecular Tumor Boards in The Netherlands: Definition, Composition, Methods, and Targeted Therapy Recommendations2020 The Oncologist article Biochemistry, Genetics and Molecular Biology Cancer Genomics and Diagnostics Open access
Bart Koopman, Harry J.M. Groen, Marjolijn J. L. Ligtenberg, Katrien Grünberg, Kim Monkhorst, Adrianus Johannes de Langen, +25 more
51citations